Potential effects and mechanisms of Chinese herbal medicine in the treatment of psoriasis

Li, Tingting; Gao, Si; Wang, Han; Gao, Ziyan; Wei, Yundong; Wu, Gang; Wei, Qiqiu; Chen, Li; Feng, Yuanjing; Yue, Shijiao; Jiang, Xudong; Kuang, Hai‐Xue

doi:10.1016/j.jep.2022.115275

Cited by 26 publications

(9 citation statements)

References 121 publications

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“…Therefore, it is urgent to develop a new therapeutic strategy with higher efficacy and fewer side effects to treat psoriasis, and Traditional Chinese medicine plays an important and active role in the treatment of the condition. 23 …”

Section: Discussionmentioning

confidence: 99%

The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis

Lu,

Pan,

et al. 2024

DDDT

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Section: Discussionmentioning

confidence: 99%

The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis

Lu,

Pan,

et al. 2024

DDDT

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Section: Introductionmentioning

confidence: 99%

“…Traditional Chinese medicine (TCM) is widely utilized for the treatment of psoriasis, with numerous clinical and experimental studies providing evidence of its effectiveness. 9 , 10 , 11 According to TCM theory, psoriasis is analyzed in terms of the concept of “blood”, which encompasses three main syndrome types: blood heat, blood dryness, and blood stasis. One commonly used TCM formula for psoriasis is Xiao‐Yin decoction, which has been shown to effectively alleviate heat, eliminate toxins, cool the blood, and improve blood circulation.…”

Section: Introductionmentioning

confidence: 99%

Tanshinone IIA, a component of the self‐made Xiao‐Yin decoction, ameliorates psoriasis by inhibiting IL‐17/IL‐23 and PTGS2/NF‐κB/AP‐1 pathways

Fu,

Li,

Wang

et al. 2024

Skin Research and Technology

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BackgroundPsoriasis is a persistent inflammatory dermatological disorder. Tanshinone IIA (tan‐IIA) is a biologically active compound in the self‐made Xiao‐Yin decoction (SMXYD) and exhibits diverse biological properties, such as anti‐proliferative and anti‐inflammatory effects. The objective of this investigation was to assess the potential of tan‐IIA as a therapeutic agent against psoriasis.MethodsNetwork pharmacology was employed to ascertain the active constituents and potential pathways associated with SMXYD and psoriasis. We conducted CCK‐8, qRT‐PCR, and western blotting to assess the proliferation of HaCaT keratinocytes and the expression of IL‐17/IL‐23 and PTGS2/NF‐κB/AP‐1 pathways. Additionally, we used H&E staining, western blotting, and ELISA to evaluate the therapeutic effects and signaling pathways of tan‐IIA in psoriasis‐like mice induced by imiquimod (IMQ).ResultsNetwork pharmacology analysis identified eight hub compounds. The Th17/IL‐17 signaling was found to be a potential therapeutic pathway of SMXYD against psoriasis, with JUN (AP‐1) as the core molecule. Next, PTGS2 was selected as the target of tan‐IIA against psoriasis using network pharmacology analysis. Molecular docking showed a high affinity between PTGS2 and tan‐IIA. Tan‐IIA treatment attenuated M‐5‐induced hyperproliferation and inflammation in HaCaT keratinocytes. Additionally, Tan‐IIA downregulated the PTGS2/NF‐κB/AP‐1 pathway in HaCaT keratinocytes. In the IMQ‐induced psoriasis‐like mouse, tan‐IIA significantly reduced the severity of skin lesions and downregulated the PTGS2/NF‐κB/AP‐1 pathway. Moreover, the combination of methotrexate (MTX) and tan‐IIA further inhibited the IL‐17/IL‐23 and PTGS2/NF‐κB/AP‐1 pathways.ConclusionThe administration of tan‐IIA has shown a positive effect on psoriasis by inhibiting the IL‐17/IL‐23 and PTGS2/NF‐κB/AP‐1 pathways. The findings suggest that it has promising qualities that make it a potential candidate for the development of future anti‐psoriatic agents.

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“…Globally, the quest for an ideal and effective treatment for psoriasis remains ongoing [2]. Although there are reports that Chinese herbal formulas, single herbs, and their active components have shown promising prospects in the clinical treatment of psoriasis [3,4,5], due to the chronic and often intractable nature of the disease, many patients have not used formal traditional Chinese medicine treatments but instead resorted to Chinese folk remedies(CFR). However, these remedies often contain a complex mix of ingredients with dangerously high levels of heavy metals.…”

Section: Introductionmentioning

confidence: 99%

Heavy metal poisoning caused by Chinese folk remedies in psoriasis patients：a retrospective analysis

Xue,

Du,

Zhu

et al. 2024

Preprint

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Psoriasis, characterized as a chronic relapsing disease with a protracted course, often drives patients to seek relief through Chinese folk remedies (CFR). Nonetheless, the complex compositions of these remedies frequently result in unintended adverse effects, notably various types of heavy metal poisoning. Our study involved an exhaustive collection and analysis of clinical data from psoriasis patients who developed heavy metal poisoning due to CFR usage, admitted to Beijing Chao-Yang Hospital from January 2011 to October 2023. Our analysis identified 44 cases of mercury poisoning, 17 of lead poisoning, 21 of arsenic poisoning, and 4 instances of mixed heavy metal poisoning. The folk remedies used ranged from fumigation and inhalation to skin application and oral administration. Distinct pathogenic characteristics were observed in each poisoning type. After treatment with metal chelating agents, all patients experienced a reduction in heavy metal levels in their bodies, accompanied by varying degrees of symptom alleviation. This study underscores the vital necessity of opting for formal, medically approved treatments for psoriasis, thereby avoiding the hazardous consequences of unregulated folk remedies that may lead to severe heavy metal poisoning.

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Potential effects and mechanisms of Chinese herbal medicine in the treatment of psoriasis

Cited by 26 publications

References 121 publications

The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis

The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis

Tanshinone IIA, a component of the self‐made Xiao‐Yin decoction, ameliorates psoriasis by inhibiting IL‐17/IL‐23 and PTGS2/NF‐κB/AP‐1 pathways

Heavy metal poisoning caused by Chinese folk remedies in psoriasis patients：a retrospective analysis

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