Potential effect of Chia Seeds Crude Extract Nanoparticles on Mcf-7 Breast Cancer Cell Line

Shaer, Nehad A.; Al-Abbas, ‏Nouf S.

doi:10.21608/aimj.2022.97818.1585

Cited by 5 publications

(3 citation statements)

References 18 publications

(22 reference statements)

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“…The anti-inflammatory and antioxidant activities of CSO could clarify its antiapoptotic impact, as exhibited by the mild caspase-3 immunoexpression in immobilized rats pre or post-restraint with CSO. Similarly, it concluded the beneficial antiapoptotic impact of the aqueous extract of chia seeds 93 .…”

Section: Discussionmentioning

confidence: 88%

Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Khalifa,

Noreldin,

Khafaga

et al. 2023

Sci Rep

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Chronic immobilization stress plays a key role in several neuropsychiatric disorders. This investigation assessed the possible ameliorative effect of chia seed oil (CSO) against the neurodisturbance-induced in rats by chronic immobilization. Rats were randomly allocated into control, CSO (1 ml/kg b.wt./orally), restrained (6 h/day), CSO pre-restraint, and CSO post-restraint for 60 days. Results revealed a significant reduction in serum corticosterone level, gene expression of corticotrophin-releasing factor, pro-inflammatory cytokines, and oxidative biomarkers in restrained rats treated with CSO. The histopathological findings revealed restoring necrosis and neuronal loss in CSO-treated-restraint rats. The immunohistochemical evaluation revealed a significant reduction in the immuno-expression of caspase-3, nuclear factor kappa B, interleukin-6, and cyclooxygenase-2 (COX-2), and an elevation of calbindin-28k and synaptophysin expression compared to non-treated restraint rats. The molecular docking showed the CSO high affinity for several target proteins, including caspase-3, COX-2, corticotropin-releasing hormone binding protein, corticotropin-releasing factor receptors 1 and 2, interleukin-1 receptor types 1 and 2, interleukin-6 receptor subunits alpha and beta. In conclusion, CSO emerges as a promising candidate against stress-induced brain disruptions by suppressing inflammatory/oxidative/apoptotic signaling pathways due to its numerous antioxidant and anti-inflammatory components, mainly α-linolenic acid. Future studies are necessary to evaluate the CSO therapeutic impacts in human neurodisturbances.

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Section: Discussionmentioning

confidence: 88%

Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Khalifa,

Noreldin,

Khafaga

et al. 2023

Sci Rep

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“…Cancer cell migration is one of the crucial steps of metastatic cascade (45). Shaer et al demonstrated the anti-migration potencial of Salvia hispanica extract prepared with PLGA-PEG coated nanoparticles system (47). In some studies, the inhibitory effect of Carthamus tinctorius on the migration of various cancer cells has been shown (3,48).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the anticancer effects of some plant seed oils with medicinal uses

Kurman¹,

Dulger²,

Pasin³

2023

jrp

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Cancer is an important health problem and responsible for a significant number of deaths worldwide. Chemotherapy resistance and related side effects prevent cancer treatment from reaching the desired level. In this study, we aimed to investigate the anti-cancer properties of Carthamus tinctorius, Salvia hispanica and Linum usitatissimum seed oils on hepatocellular (HepG2), colorectal (HCT-116) and gastric carcinoma (AGS) cell lines. Human umbilical vein endothelial cells (HUVECs) were used as control cell group. Cell viability of HepG2, HCT-116, AGS and HUVECs was determined by MTT method after treatment with various concentrations of Carthamus tinctorius, Salvia hispanica and Linum usitatissimum. Colorimetric elisa kit was used for quantitative determination of caspase-3 activation. Antimigratory effect of Carthamus tinctorius and Salvia hispanica were investigated by wound healing assay. Carthamus tinctorius, Salvia hispanica and Linum usitatissimum seed oils significantly inhibited the proliferation of cancer cells. There was an insignificant decrease in the viability of HUVEC cells after seed oils treatments. Migration of HepG2 and AGS cells significantly suppressed by treatment of Salvia hispanica and Carthamus tinctorius respectively. Salvia hispanica and Carthamus tinctorius significantly increased caspase-3 activation in cancer cells. Our results showed that Carthamus tinctorius, Salvia hispanica and Linum usitatissimum exhibited a selective cytotoxicity against HepG2, HCT-116 and AGS cells without damaging normal cells.

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“…All that was needed to create nanostructures was spontaneous emulsification during lipid hydration. The effects of utilizing chia seeds or chia seeds given by nanoparticles (Poly(lactideco-glycolide)-Poly (ethylene glycol)nanoparticles) on breast cancer cell culture were compared by Shaer and Al-Abbas (2022). Compared to regular chia seeds, chia seed nanoparticles have a more cytotoxic effect, stop cell migration, and cause apoptosis in breast cancer cells.…”

Section: How Can Chia Seeds Be Used In the Food And Nutrition Industr...mentioning

confidence: 99%

Chia (Salvia hispanica L.) Seeds: Nutritional composition and biomedical applications

Gabal

2024

Biological and Biomedical Journal

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Chia (Salvia hispanica L.) herb plant grows annually and belongs to Lamiaceae family. Its impressive health and biological benefits are due to its nutritional and phytochemical composition. Previous research has been done on chia seeds, protein hydrolysates and oil to evaluate their beneficial role in nutritional and health aspects. Chia can be incorporated in diet, food synthesis, and different industries. It can also be encapsulated to maximize its usefulness to incorporate in regular diets to enhance overall health and battle various illnesses. This review will discuss the recent findings about the nutritional values and the biomedical applications of chia seeds. Throughout this review chia source, constituents, biological activities, beneficial dosage, how to impart in our diet? and possible side effects of overconsumption will be referred. This review will also provide a comparison between the nutritional composition of Egyptian chia seeds and imported seeds.

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Potential effect of Chia Seeds Crude Extract Nanoparticles on Mcf-7 Breast Cancer Cell Line

Abstract: Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles under the following conditions: Creative Commons Attribution-Share Alike 4.0 International Public License (CC BY-SA 4.0).

Cited by 5 publications

References 18 publications

Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Investigation of the anticancer effects of some plant seed oils with medicinal uses

Chia (Salvia hispanica L.) Seeds: Nutritional composition and biomedical applications

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