Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19

Ma, Jie; Xia, Peng; Zhou, Yangzhong; Liu, Zhengyin; Zhou, Xiang; Wang, Jinglan; Li, Taisheng; Yan, Xiaowei; Chen, Limeng; Zhang, Shuyang; Qin, Yan; Li, Xuemei

doi:10.1016/j.clim.2020.108408

Cited by 164 publications

(190 citation statements)

References 8 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…The COVID-19 disease progresses rapidly when the cytokine storm occurs and immune responses increase (17). Extracorporeal blood puri cation has been proposed as one of the treatment approaches to remove these in ammatory cytokines and could potentially be bene cial in patients with severe corona virus disease (7,(9)(10)(11). It seems that the improvement of peripheral capillary oxygen saturation during the blood puri cation is related to cytokine clearance rather than reduction in volume load; because during the CRRT procedure we adjusted the uid out ow from the patient as the same amount of the uid input.…”

Section: Discussionmentioning

confidence: 99%

“…It seems that the improvement of peripheral capillary oxygen saturation during the blood puri cation is related to cytokine clearance rather than reduction in volume load; because during the CRRT procedure we adjusted the uid out ow from the patient as the same amount of the uid input. Cytokine removal following extracorporeal therapies could prevent cytokine-induced organ damages (10); and patients who underwent these therapeutic approaches in early phase of cytokine storm could have better clinical outcomes (11).…”

Section: Discussionmentioning

confidence: 99%

“…Blocking the overshoot of these in ammatory mediators can stop the sepsis process and improve patient outcomes (7). One of the treatment approaches that can be taken to reduce these cytokines is extracorporeal blood puri cation, also referred to as hemoperfusion (8)(9)(10)(11). Hemoperfusion is an extracorporeal technique involving the passage of blood through a cartridge where solutes are removed by direct binding to the sorbent material.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19)

Asgharpour

Mehdinezhad

Bayani

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines. Methods This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. No randomization and blindness was considered. All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH). Results Five men and five women with a mean age of 57.30±18.07 years have been enrolled in the study; and six of them have improved after the intervention. Peripheral capillary oxygen saturation (SpO2) changed after each session. Mean SpO2 before the three sessions of hemoperfusion was 89.60%±3.94% and increased to 92.13%±3.28% after them (p<0.001). Serum IL-6 showed a reduction from 139.70±105.62 to 72.06±65.87 pg/mL (p=0.073); and c-reactive protein increased from 136.25±84.39 to 78.25±38.67 mg/L (P=0.016). Conclusions Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19)

Asgharpour

Mehdinezhad

Bayani

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Expeditious control of the cytokine storm in early phase might be beneficial to selective patients, and case reports and small series from China and European countries have been published. 44 A recent review by Ronco et al mentions that in the absence of established drugs or vaccines for COVID-19, pathophysiological rationale may support the application of the extracorporeal therapies which might help patients who are critically ill with COVID-19 with situations such as shocklike syndrome, the need for vasopressors and capillary leak syndrome, and laboratory criteria such as the levels of IL-6 and other cytokines, as a rescue therapy. 45…”

Section: Othersmentioning

confidence: 99%

Multiorgan Involvement in COVID-19 and Possible Therapies

Sathe

Singh

2020

Journal of Cardiac Critical Care TSS

View full text Add to dashboard Cite

In late 2019, China reported cases of respiratory illness in humans, which involved a novel Coronavirus SARS-CoV-2 (also known as 2019-nCoV). The World Health Organization (WHO) termed the disease COVID-19 (i.e., Coronavirus disease 2019). Most of the morbidity and mortality from COVID-19 is largely due to acute viral pneumonitis that leads to acute respiratory distress syndrome (ARDS). This article will discuss the clinical features of the multiorgan involvement in COVID-19 as well as the management of patients who become critically ill due to COVID-19.

show abstract

“…There have also been reported cases of arterial and venous thromboembolic phenomena in the severely ill COVID-19 patients [13], typically as a result of disseminated intravascular coagulation (DIC). Nevertheless, one may see a rise in stroke presentations in association with COVID-19.…”

mentioning

confidence: 99%

COVID-19: A primer for Neuroradiologists

et al. 2020

View full text Add to dashboard Cite

The potential for central nervous system (CNS) involvement in coronavirus disease 2019 (COVID-19) is a matter of grave concern and there is a relevant body of evidence in the basic sciences to support this possibility. A neuroradiologist should be aware of the potential mechanisms involved in the neuropathogenesis of this virus, as we begin to see cases with abnormal brain scans emerging from all parts of the world.

show abstract

Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19

Cited by 164 publications

References 8 publications

Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19)

Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19)

Multiorgan Involvement in COVID-19 and Possible Therapies

COVID-19: A primer for Neuroradiologists

Contact Info

Product

Resources

About