In this work, we assessed the possible relation of ionospheric perturbations observed by Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions (DEMETER), Global Positioning System total electron content (GPS TEC), National Oceanic and Atmospheric Administration (NOAA)-derived outgoing longwave-Earth radiation (OLR), and atmospheric chemical potential (ACP) measurements, with volcanic and Saharan dust events identified by ground and satellite-based medium infrared/thermal infrared (MIR/TIR) observations. The results indicated that the Mt. Etna (Italy) volcanic activity of 2006 was probably responsible for the ionospheric perturbations revealed by DEMETER on 4 November and 6 December and by GPS TEC observations on 4 November and 12 December. This activity also affected the OLR (on 26 October; 6 and 23 November; and 2, 6, and 14 December) and ACP (on 31 October-1 November) analyses. Similarly, two massive Saharan dust episodes, detected by Robust Satellite Techniques (RST) using Spinning Enhanced Visible and Infrared Imager (SEVIRI) optical data, probably caused the ionospheric anomalies recorded, based on DEMETER and GPS TEC observations, over the Mediterranean basin in May 2008. The study confirmed the perturbing effects of volcanic and dust events on tropospheric and ionospheric parameters. Further, it demonstrated the advantages of using independent satellite observations to investigate atmospheric phenomena, which may not always be well documented. The impact of this increased detection capacity in reducing false positives, in the framework of a short-term seismic hazard forecast based on the study of ionospheric and tropospheric anomalies, is also addressed. reach 200 kV/m or more. Saunders [22] claimed that inside thunderstorm clouds, the field rarely exceeded 400 kV/m, and that an average value could be of the order of 100 kV/m. Therefore, it is likely that electrostatic discharges could occur at the time of sandstorms.Concerning volcanic eruptions, these phenomena produce two different types of electromagnetic perturbations in the upper atmosphere. On the one hand, they are sometimes accompanied by lightning strokes, and on the other hand, their effects are similar to explosions (i.e., acoustic-gravity waves are emitted). Volcanic eruptions may perturb the environment up to the ionosphere, owing to the propagation of acoustic-gravity waves (their amplitude increases with the decrease of the density in altitude). Other authors reported some ionospheric variations in the records of HF (High Frequency) Doppler and TEC (Total Electron Content) data, in association with the explosions of Mount Pinatubo on 15 June 1991 [2]. Lightning activities in volcanic plumes have been observed for a long time. There have been, in fact, many reports concerning some spectacular events (e.g., [23][24][25][26][27][28][29]), including the April-May 2010 Eyjafjallajökull eruption, which strongly perturbed air traffic (e.g., [30]). Antel et al. [31] showed that the number of whistlers (waves associated to the ...