Potential drug–drug interactions within Veterans Affairs medical centers

Mahmood, Maysaa; Malone, Daniel C.; Skrepnek, Grant H.; Abarca, Jacob; Armstrong, Edward P.; Murphy, John E.; Grizzle, Amy J.; Ko, Yu; Woosley, Raymond L.

doi:10.2146/ajhp060548

Cited by 30 publications

(32 citation statements)

References 45 publications

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“…1,5,7,19,20 A study of pharmacy records from VA ambulatory care clinics found that the rate of exposure to 25 potential DDIs was 2.2%. 20 Another study on the frequency of potential DDIs in a pharmacy benefits manager's drug database revealed that the potential DDI pair with the highest prevalence rate (warfarin/non-steroidal anti-inflammatory drug) occurred at a rate of 279 per 100,000 persons. 19 Studies documenting the dangers of DDIs underscore the need to be able to detect and prevent potential drug interactions.…”

Section: Discussionmentioning

confidence: 99%

Pharmacy Students' Ability to Identify Potential Drug-Drug Interactions

Saverno¹,

Malone²,

Kurowsky³

2009

Am J Pharm Educ

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Objective. To evaluate the ability of third-and fourth-year pharmacy students to identify clinically significant drug-drug interactions (DDIs) Methods. A questionnaire designed to measure DDI knowledge was disseminated to fourth-year pharmacy students in a school of pharmacy. A second questionnaire was distributed to third-year pharmacy students in 2 schools of pharmacy (schools A and B) and re-administered to students in 1 of the schools 1 year later. Results. Class of 2005 fourth-year pharmacy students correctly categorized an average of 52% 6 13% DDI pairs on the first questionnaire. Third-year pharmacy students at schools A and B correctly categorized an average of 61% 6 18% and 66% 6 15% of DDI pairs, respectively. The average percentage of correct responses for fourth-year students from the class of 2007 was 65% (6 17%). Conclusion. Pharmacy students' ability to identify important DDIs is far from optimal, even after completing experiential requirements.

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Section: Discussionmentioning

confidence: 99%

Pharmacy Students' Ability to Identify Potential Drug-Drug Interactions

Saverno¹,

Malone²,

Kurowsky³

2009

Am J Pharm Educ

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“…18 A list of 25 clinically important DDIs that were most likely to be encountered in ambulatory care settings was used in this study. 19 Anonymous pharmacy records for VA health care system beneficiaries were provided at the national level by VA PBM, which included data from the surveyed VAMCs related to veterans who filled prescriptions during the period from July 1, 2003, to June 30, 2004.…”

Section: Methodsmentioning

confidence: 99%

Relationship between pharmaceutical services characteristics and exposure rates to drug–drug interactions in Veterans Affairs medical centers

Mahmood

Armstrong

Malone

et al. 2008

American Journal of Health-System Pharmacy

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“…Even though DDIs are considered as preventable medication-related problems, studies found that up to 11% of patients experience symptoms associated with DDI and these are responsible for nearly 2.8% of hospital admissions [8]. Monitoring of DDIs may improve the quality of prescribing and dispensing, and it might form a basis for education focused on appropriate prescribing [9].…”

Section: Introductionmentioning

confidence: 99%

“…Monitoring of DDIs may improve the quality of prescribing and dispensing, and it might form a basis for education focused on appropriate prescribing [9]. Drug-Drug Interactions (DDIs) are estimated to account for 6%-30% of all the adverse drug events, and they continue to pose a significant risk to the patient's health outcomes and a considerable economic burden on the healthcare system [8]. Hence, as they are an important hazard to the health of millions of patients, drug-drug interactions have to be tackled and it is the need of the hour.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Potential Drug–drug Interaction in Stroke Patients

Venkateswaramurthy¹,

Krishnaveni²,

Freeda³

et al. 2016

Int J Pharm Pharm Sci

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Objective: To assess the incidence and pattern of potential drug-drug interaction (pDDI) in hospitalized stroke patients.Methods: A retrospective study was carried out in a medical record from a tertiary care teaching hospital for a 4 mo period from November 2015-February 2016. The total of 200 prescriptions was analyzed during the study period.Results: A significant proportion of patients with pDDIs were males (61.5%) followed by females (38.5%). Among the 200 prescriptions, 179(89.5%) were confirmed with minimum one potential drug-drug interaction. Moreover, patients prescribed with more than 5 drugs developed a higher number of interactions. Based on severity scale, there were 125 major, 375 moderate and 128 minor interactions were observed. The pharmacodynamic interactions were 286 while the pharmacokinetic were 342. Conclusion:The study highlighted the pDDIs which were high in stroke patients greater than 40 y. pDDIs in prescriptions contained multi-drug therapy is a major concern as such interaction may lead to increased risk of hospitalization and higher health care cost. The majority of interactions were pharmacokinetic in nature, having moderate severity. In this study pDDIs mainly occurred between antihypertensive, anticoagulants and antiplatelet.

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Potential drug–drug interactions within Veterans Affairs medical centers

Cited by 30 publications

References 45 publications

Pharmacy Students' Ability to Identify Potential Drug-Drug Interactions

Pharmacy Students' Ability to Identify Potential Drug-Drug Interactions

Relationship between pharmaceutical services characteristics and exposure rates to drug–drug interactions in Veterans Affairs medical centers

Assessment of Potential Drug–drug Interaction in Stroke Patients

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