Potential drug-drug interactions in patients presenting with osteoarthritis to community orthopaedic clinics of Abbottabad, Khyber Pakhtunkhwa: A cross-sectional study

Rehman, Ihtesham Ur; Khan, Qudrat; Sharif, Muhammad Junaid Hassan; Bashir, Hamid; Iqbal, Muhammad Kashif; Amirzada, Muhammad Imran

doi:10.1016/j.pharma.2023.05.005

Cited by 1 publication

(1 citation statement)

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“…Since minor DDIs generally do not have a significant effect on clinical outcomes, no change in treatment is required in such cases. However, in moderate and serious interactions, many precautions must be taken, such as a dosage change, a change in the active ingredient, or closer patient monitoring [5]. Sadowski and Gugler and Allgayer put forth that DDIs caused by antacids do not cause serious health problems.…”

Section: Introductionmentioning

confidence: 99%

Bi̇r Toplum Eczanesi̇nde Karşilaşilan Anti̇asi̇tler Kaynakli İlaç Etki̇leşi̇mleri̇ni̇n Tespi̇ti̇: Gözlemsel Bi̇r Çalişma

GÖKEŞ,

ARSLAN

2024

Ankara Ecz. Fak. Derg.

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Objective: This study aimed to reveal drug-drug interactions (DDIs) due to antacids through programs used to detect DDIs. Material and Method: Within the scope of this study, 207 prescriptions containing at least one antacid and a drug from a different pharmacological group were evaluated in terms of DDIs. Evaluations were made on the prescriptions received in a community pharmacy serving in Van, Türkiye. Three different DDI checking programs were used for this evaluation. Result and Discussion: Antacid-induced DDIs were detected in 64 of the prescriptions. Interactions occurred between 52 active ingredient pairs, and it was revealed that DDIs were most common between calcium carbonate and famotidine. This interaction is minor and has been detected by only one database. Another common interaction was found between the calcium carbonate and cholecalciferol (Vitamin D) pair, and this interaction was reported as Level 2 and should be closely monitored in two different databases. As a result, DDIs induced by antiacids generally were found to be at moderate levels. However, it is seen that three DDI checking programs used in the study provide different results in detecting DDIs.

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Section: Introductionmentioning

confidence: 99%