Potential drug–drug interactions and radiodiagnostic procedures: an in-hospital survey

Lapi, Francesco; Vietri, Michele; Mihalj, Martina; Cecchi, Emanuele; Pugi, Alessandra; Lucenteforte, Ersilia; Banchelli, G.; Pirro, Marina Di; Gallo, Eugenia; Mugelli, Alessandro; Vannacci, Alfredo

doi:10.1007/s11096-010-9370-4

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…No statistically significant differences were found between men and women regarding DDIs, which is consistent with findings described in previous studies carried out in primary care settings [11], [29], [34] as well as investigations carried out in other settings [35], [36]. Age is another important variable to consider in relation to drug use.…”

Section: Discussionsupporting

confidence: 90%

Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil

et al. 2012

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BackgroundFew cross-sectional studies involving adults and elderly patients with major DDIs have been conducted in the primary care setting. The study aimed to investigate the prevalence of potential drug-drug interactions (DDIs) in patients treated in primary care.Methodology/Principal FindingsA cross-sectional study involving patients aged 45 years or older was conducted at 25 Basic Health Units in the city of Maringá (southern Brazil) from May to December 2010. The data were collected from prescriptions at the pharmacy of the health unit at the time of the delivery of medication to the patient. After delivery, the researcher checked the electronic medical records of the patient. A total of 827 patients were investigated (mean age: 64.1; mean number of medications: 4.4). DDIs were identified in the Micromedex® database. The prevalence of potential DDIs and major DDIs was 63.0% and 12.1%, respectively. In both the univariate and multivariate analyses, the number of drugs prescribed was significantly associated with potential DDIs, with an increasing risk from three to five drugs (OR = 4.74; 95% CI: 2.90–7.73) to six or more drugs (OR = 23.03; 95% CI: 10.42–50.91). Forty drugs accounted for 122 pairs of major DDIs, the most frequent of which involved simvastatin (23.8%), captopril/enalapril (16.4%) and fluoxetine (16.4%).Conclusions/SignificanceThis is the first large-scale study on primary care carried out in Latin America. Based on the findings, the estimated prevalence of potential DDIs was high, whereas clinically significant DDIs occurred in a smaller proportion. Exposing patients to a greater number of prescription drugs, especially three or more, proved to be a significant predictor of DDIs. Prescribers should be more aware of potential DDIs. Future studies should assess potential DDIs in primary care over a longer period of time.

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Section: Discussionsupporting

confidence: 90%

Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil

et al. 2012

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“…In the same country, the study of Aparasus et al (2007) showed that over 11% of patients experience symptoms associated with DI, which led to increase of health care costs. According to Lapi et al (2010), it is estimated that there are more than 100,000 combinations of drugs, which may be responsible for several adverse drug events. Hammes et al (2008) defined DI as a specific type of adverse event that occurs when the effects of a drug are altered by the presence of another.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical intervention assessment in the identification and management of drug interactions in an intensive care unit

2015

J App Pharm Sci

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It is estimated there are thousands of combinations of drugs, which may generate various adverse drug events, including drug interactions (DI). To assess the contribution of pharmacist to identification and management of DI in an intensive care unit (ICU). A longitudinal study was conducted in the ICU of a private hospital in the city of Aracaju-SE, between 2008 and 2009. The prevalence and clinical relevance of DI was assessed by two clinical pharmacists. Demographic data and clinical information of patients hospitalized in the period of the study were obtained from medical records. At the end of the study 137 medical records were analyzed, with a predominance of female patients (55.4%), average age of 66 (±7.0) years. 6,085 prescriptions were collected during the study period, in which 2,455 drugs prescribed. Of these, 175 prescriptions contained clinically relevant DI, 178 of moderate severity and 35 of major severity, 213 DI in total. The clinical pharmacists prepared reports for the physicians, which enabled the reduction of 40% of all DI. Data from this study suggest that pharmacist's contribution may have reduced the incidence of DI, providing more familiarity of physicians on clinically relevant information and improving the quality of prescriptions in the ICU.

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Potential drug–drug interactions and radiodiagnostic procedures: an in-hospital survey

Cited by 3 publications

References 27 publications

Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil

Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil

Pharmaceutical intervention assessment in the identification and management of drug interactions in an intensive care unit

Current awareness: Pharmacoepidemiology and drug safety

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