Potential Drug Combinations to Reduce Cardiovascular Disease Burden in Diabetes

Pillarisetti, Sivaram

doi:10.1016/j.tips.2015.11.009

Cited by 12 publications

(12 citation statements)

References 109 publications

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“…The treatment targeted at postprandial glucose homeostasis, which is involved in the prediction of CVD and all‐cause mortality, has been reported to reduce the progression of atherosclerosis and CVD events . Previous studies have demonstrated the potential of high‐fat meals to induce β‐cell dysfunction and insulin resistance in healthy subjects and in individuals with high fasting plasma triglycerides, type 2 diabetes or MetS .…”

Section: Discussionmentioning

confidence: 99%

“…The treatment targeted at postprandial glucose homeostasis, which is involved in the prediction of CVD and all-cause mortality, has been reported to reduce the progression of atherosclerosis and CVD events. 17 Previous studies have demonstrated the potential of high-fat meals to induce -cell dysfunction and insulin resistance in healthy subjects 7,18 and in individuals with high fasting plasma triglycerides, 8 type 2 diabetes 19 or MetS. 20 The evolution of type 2 diabetes may be related to the progressive deterioration of glucose homeostasis, starting during the postprandial period in subjects whose glycemic profiles are normal at fasting.…”

Section: Discussionmentioning

confidence: 99%

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Effects of immediate‐release niacin and dietary fatty acids on acute insulin and lipid status in individuals with metabolic syndrome

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of immediate‐release niacin and dietary fatty acids on acute insulin and lipid status in individuals with metabolic syndrome

et al. 2017

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“…The multiple complications of T2DM may affect each other and reduce the survival rate of patients. For example, in about 65% of T2DM patients, who die of cardiovascular disease, dyslipidemia is one of its important predisposing factors [ 1 , 13 ]. There are a large number of patients with T2DM associated with varying degrees of dyslipidemia characterized by triglyceride (TG) increase and high density lipoprotein decrease [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, in about 65% of T2DM patients, who die of cardiovascular disease, dyslipidemia is one of its important predisposing factors [ 1 , 13 ]. There are a large number of patients with T2DM associated with varying degrees of dyslipidemia characterized by triglyceride (TG) increase and high density lipoprotein decrease [ 13 , 14 ]. Bijelic et al reported that the LDL cholesterol and triglycerides were significant risk factors for osteoporosis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Fenofibrate decreases the bone quality by down regulating Runx2 in high-fat-diet induced Type 2 diabetes mellitus mouse model

et al. 2017

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BackgroundThis study is to investigate the effect of fenofibrate on the bone quality of Type 2 diabetes mellitus (T2DM) mouse model.MethodsT2DM mouse model was induced by high-fat-diet, and the mice were treated with fenofibrate (100 mg/kg) (DIO-FENO) or PBS (DIO-PBS) for 4 weeks. The bone microstructure and biomechanical properties of femora were analyzed by micro-CT and 3-Point bending test. The protein expression was detected by immunohistochemical staining and Western blot. The cell apoptosis was evaluated by TUNEL staining. The Bcl2, caspase 3, and osteoblast marker genes were detected by RT-qPCR.ResultsThe biomechanical properties of bones from DIO-FENO group were significantly lower than those in the control and DIO-PBS groups. Besides, the trabecular number was lower than those of the other groups, though the cortical porosity was decreased compared with that of DIO-PBS group because of the increase of apoptotic cells. The expression of osteocalcin and collagen I were decreased after treatment with fenofibrate in T2DM mice. Moreover, the cell viability was decreased after treated with different concentrations of fenofibrate, and the expression of Runx2 decreased after treated with high dose of fenofibrate.ConclusionFenofibrate decreases the bone quality of T2DM mice through decreasing the expression of collagen I and osteocalcin, which may be resulted from the down regulation of Runx2 expression.

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“…In addition, the ACCORD (Action to Control Cardiovascular Risk in Diabetes) trials suggested that an intensive glycemia strategy exerts adverse effects on cardiovascular outcomes during disease progression [13] . Recently, increasing evidence suggests the necessity of drug combinations for reducing CVR [14] . Salvianolic acid A (Sal A), one of the main active compounds in an aqueous extract of the herb Salvia miltiorrhiza, has been validated to exert a wide-range of cardioprotective effects.…”

Section: Introductionmentioning

confidence: 99%

A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats

et al. 2017

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Cardiovascular complications represent a leading cause of mortality in patients with type 2 diabetes mellitus (T2DM). During such complicated progression, subtle variations in the cardiovascular risk (CVR)-related biomarkers have been used to identify cardiovascular disease at the incipient stage. In this study we attempt to integrally characterize the progression of cardiovascular complications and to assess the beneficial effects of metformin combined with salvianolic acid A (Sal A), in Goto-Kakizaki (GK) rats with spontaneous T2DM. The rats were treated with metformin ( , ip) at ages from 8 to 22 weeks. During the treatment, the levels of asymmetric dimethylarginine, L-arginine, superoxide dismutase, malondialdehyde, glucose, high density lipoprotein and low density lipoprotein were assessed. Based on alterations in these biomarkers, a mini-network balance model was established using matrixes and vectors. Radar charts were created to visually depict the disruption of CVR-related modules (endothelial function, oxidative stress, glycation and lipid profiles). The description for the progression of cardiovascular disorder was quantitatively represented by u, the dynamic parameter of the model. The modeling results suggested that untreated GK rats tended to have more severe cardiovascular complications than the treatment groups. Metformin monotherapy retarded disease deterioration, whereas the combination treatment ameliorated the disease progression via restoring the balance. The current study, which focused on the balance of the mini-network and interactions among CVR-related modules, proposes a novel method for evaluating the progression of cardiovascular complications in T2DM as well as a more beneficial intervention strategy.

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Potential Drug Combinations to Reduce Cardiovascular Disease Burden in Diabetes

Cited by 12 publications

References 109 publications

Effects of immediate‐release niacin and dietary fatty acids on acute insulin and lipid status in individuals with metabolic syndrome

Effects of immediate‐release niacin and dietary fatty acids on acute insulin and lipid status in individuals with metabolic syndrome

Fenofibrate decreases the bone quality by down regulating Runx2 in high-fat-diet induced Type 2 diabetes mellitus mouse model

A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats

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