Potential diagnostic and therapeutic value of circular RNAs in cardiovascular diseases

Sun, Jin‐Yu; Shi, Yan; Cai, Xinyong; Liu, Jiao

doi:10.1016/j.cellsig.2020.109604

Cited by 24 publications

(21 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been established that circular RNAs play a crucial role in the development of a variety of human diseases, 17 including cardiovascular diseases. 4 improving the myocardial function and prognosis of MI. 9 It has been revealed that circ-Ttc3 reduced myocardial ATP depletion and apoptosis by sponging miR-15b.…”

Section: Discussionmentioning

confidence: 99%

“…It has been established that circular RNAs play a crucial role in the development of a variety of human diseases, 17 including cardiovascular diseases 4 . So far, a few studies have been conducted to determine the possible effects of circRNAs on AMI.…”

Section: Discussionmentioning

confidence: 99%

“…Circular RNAs are involved in the development of human cardiovascular diseases 4 . Deep RNA‐sequencing identified a total of 15 318 and 3017 circRNA in human and mouse hearts 5 .…”

Section: Introductionmentioning

confidence: 99%

“…Circular RNAs are involved in the development of human cardiovascular diseases. 4 Deep RNA-sequencing identified a total of 15 318 and 3017 circRNA in human and mouse hearts. 5 Microarray analysis showed that knockdown of circCHFR could effectively suppress the proliferation and migration of oxidatively modified low-density lipoprotein-induced vascular smooth muscle cells.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF‐κB activation

Zhai

Qian

Wu³

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Acute myocardial infarction (AMI) is one of the most severe manifestations of coronary artery disease, caused by complete or partial occlusion of a coronary artery. In 2015, the global AMI cases were estimated to be 7.3 million, and South Asia had the highest age-standardized myocardial infarction incidence. 1 Although the mortality rate of AMI in high-income countries has been declining over the past decades because of evidence-based AMI care and therapy, 2 AMI remains a global health priority, especially in

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Circular RNAs are involved in the development of human cardiovascular diseases 4 . Deep RNA‐sequencing identified a total of 15 318 and 3017 circRNA in human and mouse hearts 5 .…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF‐κB activation

Zhai

Qian

Wu³

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…To develop a new therapeutic method, hsa_circ_0097435 can be a promising target [11]. Additionally, circRNAs play a role in atherosclerosis, coronary artery disease, myocardial infarction, as well as cardiomyopathy [12].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Differentially Expressed Profiles of circRNAs in Diabetic Cardiomyopathy

Wu¹,

Cheng²,

Zhang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Objective: To assess the circular RNAs (circRNA) expression profile and explore their potential functions in diabetic cardiomyopathy (DCM). Methods: Using an STZ induced DCM model, microarray analysis was adopted to assess the circRNAs profiles. Then 6 differentially expressed circRNAs were confirmed by quantitative Real-Time PCR. Furthermore, gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and TargetScan were used to reveal the underlying function of the differentially expressed circRNAs. Cytoscape was used to visualize the interaction networks as well. Results: We revealed a total of 171dyrgulated circRNAs, including 89 upregulated, and 82 downregulated circRNAs in DCM. And confirmed 5 circRNAs distinct expressions (rno_circRNA_000466, rno_circRNA_000964, rno_circRNA_003395, rno_circRNA_000173, rno_circRNA_013989) in DCM by qRT-PCR. GO, and KEGG pathway enrichment revealed the differentially expressed circRNAs might participate in the insulin signaling pathway, autophagy, HIF-1 signaling pathway, inflammatory mediator regulation of TRP channels. rno_circRNA_000466 function through competing endogenous RNA mechanism, and may involve in the TGF-β signaling pathway, regulation of glucose transmembrane transport, endocrine process and response to lipoprotein particle. Conclusions: This study opens new avenues for a better understanding of the involvement of circRNA leading to DCM. And unveiled the specific role of rno_circRNA_000466 in the pathogenesis of DCM. These results may provide important information and direction for the future development of novel targets for the treatment of DCM.

show abstract

Lag effect of ambient temperature on the cardiovascular disease hospital admission in Jiuquan, China

Zhai

Chai

2020

Air Qual Atmos Health

View full text Add to dashboard Cite

Potential diagnostic and therapeutic value of circular RNAs in cardiovascular diseases

Cited by 24 publications

References 57 publications

Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF‐κB activation

Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF‐κB activation

Comprehensive Analysis of Differentially Expressed Profiles of circRNAs in Diabetic Cardiomyopathy

Lag effect of ambient temperature on the cardiovascular disease hospital admission in Jiuquan, China

Contact Info

Product

Resources

About