Potential Diagnostic and Monitoring Biomarkers of Obstructive Sleep Apnea–Umbrella Review of Meta-Analyses

Fiedorczuk, Piotr; Polecka, Agnieszka; Walasek, Marzena; Olszewska, Ewa

doi:10.3390/jcm12010060

Cited by 21 publications

(15 citation statements)

References 130 publications

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“…In conclusion, it is important to discover new biomarkers through innovative diagnostic tools [ 134 , 135 ], opening a new translational phase aimed at tuning oxidative profiles in OSAS patients.…”

Section: Discussionmentioning

confidence: 99%

Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea

Meliante

Zoccali

Cascone

et al. 2023

IJMS

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Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent hypoxia (IH) during sleep due to recurrent upper airway obstruction. The derived oxidative stress (OS) leads to complications that do not only concern the sleep-wake rhythm but also systemic dysfunctions. The aim of this narrative literature review is to investigate molecular alterations, diagnostic markers, and potential medical therapies for OSAS. We analyzed the literature and synthesized the evidence collected. IH increases oxygen free radicals (ROS) and reduces antioxidant capacities. OS and metabolic alterations lead OSAS patients to undergo endothelial dysfunction, osteoporosis, systemic inflammation, increased cardiovascular risk, pulmonary remodeling, and neurological alterations. We treated molecular alterations known to date as useful for understanding the pathogenetic mechanisms and for their potential application as diagnostic markers. The most promising pharmacological therapies are those based on N-acetylcysteine (NAC), Vitamin C, Leptin, Dronabinol, or Atomoxetine + Oxybutynin, but all require further experimentation. CPAP remains the approved therapy capable of reversing most of the known molecular alterations; future drugs may be useful in treating the remaining dysfunctions.

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Section: Discussionmentioning

confidence: 99%

Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea

Meliante

Zoccali

Cascone

et al. 2023

IJMS

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show abstract

“…In sputum only did leptin correlate with fat area, and VEGF level showed a relationship to OSA severity 118 . However, Fiedorczuk et al showed that in OSA patients, blood levels of VEGF and leptin are increased and decrease after continuous positive airway pressure treatment 119 . Katagiri et al found that, in patients with diabetic retinopathy, the vitreous levels of leptin and VEGF are correlated with levels of placental growth factor; they concluded that elevated vitreous levels of VEGF may be linked to severe diabetic retinopathy 120 .…”

Section: Resultsmentioning

confidence: 99%

“…118 However, Fiedorczuk et al showed that in OSA patients, blood levels of VEGF and leptin are increased and decrease after continuous positive airway pressure treatment. 119 Katagiri et al found that, in patients with diabetic retinopathy, the vitreous levels of leptin and VEGF are correlated with levels of placental growth factor; they concluded that elevated vitreous levels of VEGF may be linked to severe diabetic retinopathy. 120 Further, Seung Yang et al found that the logarithm of the intraocular leptin level correlates with the logarithm of serum adiponectin concentration and that level of VEGF in aqueous humor correlates with blood level of adiponectin in diabetic patients with diabetic retinopathy.…”

Section: Human Studiesmentioning

confidence: 99%

Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review

Skrypnik

Suliburska

et al. 2023

Obesity Reviews

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Summary By 2030, it is expected that a billion people will have suffer from obesity. Adipose tissue synthesizes leptin, an adipokine that affects cardiovascular risk. Leptin intensifies the synthesis of vascular endothelial growth factor (VEGF). Our study reviews recent reports on leptin–VEGF crosstalk in obesity and related disorders. PubMed, Web of Science, Scopus, and Google Scholar were searched. One hundred and one articles involving human, animal, and in vitro research were included. In vitro studies show the crucial role of interaction between endothelial cells and adipocytes and hypoxia as a factor that intensifies leptin's effects on VEGF. Leptin–VEGF crosstalk promotes the progression of cancer. The animal research reveal that a high‐fat diet enhances leptin and VEGF crosstalk. Genetic and epigenetic mechanisms and procreator‐offspring programming may be involved in leptin–VEGF crosstalk. Some female‐specific characteristics of leptin–VEGF relation in obesity were observed. The human studies have shown that increased leptin and VEGF synthesis and leptin–VEGF crosstalk are factors linking obesity with elevated cardiovascular risk. The studies of the last 10 years documented a range of significant aspects of leptin–VEGF crosstalk specific for obesity and related disorders, shedding new light on the link between obesity and increased cardiovascular risk.

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“…Recent studies have demonstrated a moderate relationship between elevated levels of in ammatory mediators and OSA, according to the evaluation of plasma or serum samples [11]. Likewise, salivary biomarkers, such as cortisol, are likely predictive of OSA severity [12].…”

Section: Introductionmentioning

confidence: 99%

Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels

Bisatto,

Crescente,

Fritscher

et al. 2024

Preprint

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Introduction It has been suggested that dentofacial deformities (DFD) can impair sleep quality. This pilot study aimed at evaluating sleep disorders in individuals with DFD before orthognathic surgery, correlating the clinical findings with salivary biomarker levels. Materials and Methods This cross-sectional study enrolled ten males and ten females with DFD diagnoses under orthodontic treatment preceding orthognathic surgery. The participants responded to the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Fletcher and Luckett Sleep Questionnaire (FLSQ). Obstructive sleep apnea (OSA) was examined by the Home Sleep Apnea Test (HSAT). The salivary levels of interleukin-1β (IL-1β), glutamate, and serotonin were measured. Results Eighty-five% of individuals presented PSQI and FLSQ scores indicative of sleep alterations. Females had higher scores in part 2 of the FLSQ instrument, referring to sleepiness-associated complaints. HSAT analysis revealed a low number of symptomatic OSA individuals, with three males demonstrating altered oxygen desaturation rates. There was a significant negative correlation between the salivary levels of serotonin and the FLSQ results. Discussion Individuals with DFD diagnosis showed poorer sleep quality, which is likely independent of sex and OSA diagnosis, and negatively correlated with salivary levels of serotonin.

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Potential Diagnostic and Monitoring Biomarkers of Obstructive Sleep Apnea–Umbrella Review of Meta-Analyses

Cited by 21 publications

References 130 publications

Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea

Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea

Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review

Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels

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