Potential cross-species correlations in social hierarchy and memory between mice and young children

Chou, Yu-Ju; Ma, Yu-Kai; Lu, Yi-Han; King, Jung-Tai; Tasi, Wen-Sheng; Yang, Sheng‐Ming; Kuo, Tsung-Han

doi:10.1038/s42003-022-03173-7

Cited by 7 publications

(2 citation statements)

References 82 publications

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“…A recent finding suggests that social dominance and mnemonic abilities are correlated in young human children and mice. 31 These results demonstrate that the behavior of the dominant mouse is different from that of other cagemates, implying that various social and nonsocial behaviors are modulated by social rank.…”

Section: Discussionmentioning

confidence: 84%

Differential effects of oxytocin receptor antagonist on social rank and other social behavior in male mice

Nasukawa

Yamada

Hirakata

et al. 2022

Preprint

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Social rank within a group is essential for survival in many animals. Rank in the community helps to avoid unnecessary conflicts and establish stable relationships with others. Recently, oxytocin has received increasing attention for its function in social behavior. However, the causal relationship between oxytocin levels and social rank has remained unclear. Here, we examined the effects of intraperitoneal injection of the oxytocin receptor antagonist L-368-899 on (1) social rank, (2) sex preference, and (3) dyadic interaction in male mice. In the tube test, injection of the oxytocin receptor antagonist had no effect on first-place mice, but caused rank fluctuation of the social rank in second-place mice, suggesting that the function of oxytocin in the maintenance of the social rank is rank-dependent. Second, injection of the oxytocin receptor antagonist dose-dependently impaired the sex preference of the male mice, confirming that oxytocin is essential in sexual behavior. Third, injection of the oxytocin receptor antagonist had no effect on the dyadic interaction between the male mice, suggesting that oxytocin is not necessary in direct social interaction. Taken together, these results demonstrate that the role of the oxytocin in male mice is limited to a specific context of social behavior.

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Section: Discussionmentioning

confidence: 84%

Differential effects of oxytocin receptor antagonist on social rank and other social behavior in male mice

Nasukawa

Yamada

Hirakata

et al. 2022

Preprint

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show abstract

“…Social dominance hierarchy is a common phenomenon among social animals [ 1 , 2 , 3 , 4 ]. Social hierarchies determine the quantity and quality of resources, profoundly influencing the survival, health, reproduction and other behaviors of social animals [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Social Hierarchy Dictates Intestinal Radiation Injury in a Gut Microbiota-Dependent Manner

Zeng

Liu

Dong

et al. 2022

IJMS

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Social hierarchy governs the physiological and biochemical behaviors of animals. Intestinal radiation injuries are common complications connected with radiotherapy. However, it remains unclear whether social hierarchy impacts the development of radiation-induced intestinal toxicity. Dominant mice exhibited more serious intestinal toxicity following total abdominal irradiation compared with their subordinate counterparts, as judged by higher inflammatory status and lower epithelial integrity. Radiation-elicited changes in gut microbiota varied between dominant and subordinate mice, being more overt in mice of higher status. Deletion of gut microbes by using an antibiotic cocktail or restructuring of the gut microecology of dominant mice by using fecal microbiome from their subordinate companions erased the difference in radiogenic intestinal injuries. Lactobacillus murinus and Akkermansia muciniphila were both found to be potential probiotics for use against radiation toxicity in mouse models without social hierarchy. However, only Akkermansia muciniphila showed stable colonization in the digestive tracts of dominant mice, and significantly mitigated their intestinal radiation injuries. Our findings demonstrate that social hierarchy impacts the development of radiation-induced intestinal injuries, in a manner dependent on gut microbiota. The results also suggest that the gut microhabitats of hosts determine the colonization and efficacy of foreign probiotics. Thus, screening suitable microbial preparations based on the gut microecology of patients might be necessary in clinical application.

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Differences in physiology and behavior between male winner and loser mice in the tube test

Wang,

Huang,

Cai

et al. 2024

Behavioural Processes

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Potential cross-species correlations in social hierarchy and memory between mice and young children

Cited by 7 publications

References 82 publications

Differential effects of oxytocin receptor antagonist on social rank and other social behavior in male mice

Differential effects of oxytocin receptor antagonist on social rank and other social behavior in male mice

Social Hierarchy Dictates Intestinal Radiation Injury in a Gut Microbiota-Dependent Manner

Differences in physiology and behavior between male winner and loser mice in the tube test

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