Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells

Bassani, Barbara; Rossi, Teresa; Stefano, Daniela De; Pizzichini, Daniele; Corradino, Paola; Macrì, Nicoletta; Noonan, Douglas M.; Albini, Adriana; Bruno, Antonino

doi:10.1016/j.jff.2016.09.009

Cited by 40 publications

(49 citation statements)

References 52 publications

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“…The TNF-α-induced formation of IL-8 in HaCaT cells was down-regulated by the OMWW extract in a dose-dependent manner. This result is in accordance with the reported down-regulation of IL-8 in colon cancer cells by OMWW and hydroxytyrosol [12]. Several studies reported the anti-tumor activity of polyphenols [14,22,23] and discussed different chemo-preventive mechanisms [24].…”

Section: Discussionsupporting

confidence: 90%

“…The composition of the OMWW extract is essential for health-promoting effects, and strongly depends on the cultivation conditions of olive trees as well as on the applied preparation techniques [8]. Previous studies using this phenol-enriched OMWW extract revealed the anti-angiogenic and angiopreventive activity in endothelial cells [14] and the potential chemo-preventive properties in colon cancer [12]. Polyphenols are associated with several positive effects on cell viability and proliferation, inflammatory processes, microbiological growth and the formation of reactive oxygen species [18].…”

Section: Discussionmentioning

confidence: 99%

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Effects of a Phenol-Enriched Purified Extract from Olive Mill Wastewater on Skin Cells

et al. 2019

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Olive trees (Olea europaea) and their processed products, such as olive oil, play a major role in the Mediterranean way of life. Their positive impact on human health is being intensely investigated. One research topic is the identification of new application areas of olive mill wastewater (OMWW). OMWW is characterized by the high content of polyphenols possessing many positive health effects. Thus, the phenol-enriched OMWW extract offers the potential for the treatment of skin disorders and for cosmetic application. The aim of the present study was to evaluate cell viability and proliferation, the anti-inflammatory and anti-oxidative properties of a phenol-enriched OMWW extract on an immortal keratinocyte cell line (HaCaT cells). Moreover, the influence on the growth of various microorganisms was investigated; furthermore, the effects on normal human epidermal keratinocytes (NHEK) and human melanoma cells (A375) were studied in a commercially available tumor invasion skin model. The phenol-enriched OMWW extract showed excellent antimicrobial activity. Moreover, a noticeable reduction in reactive oxygen species formation as well as Interleukin-8 release in HaCaT cells were observed. Finally, the inhibited growth of A375 melanoma nodules in the melanoma skin model could be shown. Our results indicate that the OMWW extract is a promising ingredient for dermal applications to improve skin health and skin protection as well as having a positive impact on skin ageing.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Effects of a Phenol-Enriched Purified Extract from Olive Mill Wastewater on Skin Cells

et al. 2019

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“…Olive oil In vitro Anti-inflammatory effects Anti-proliferative activities by inhibition apoptosis in CRC cells Cancer chemopreventive properties for CRC cells. [88] Japanese quince (Chaenomeles japonica)…”

Section: Direct and Gut-microbiota-modulating Mechanisms Of Action Ofmentioning

confidence: 99%

“…This effect significantly suppressed the secretion of several cytokines expression (for example IL-1β, TNF-α, IL-6, IL-17, and IFN-γ) and reduced the colonic infiltration of CD3+T cells producing these cytokines and neutrophils, and contributed to preventing adenoma formation. On the other hand, several authors explain that polyphenols' anticancer activity is due to their anti-inflammatory and antioxidant properties, mainly mediated by their ability to down-regulate the nuclear factor NF-kB, modulating crucial cell signaling pathways involved in inflammation and cancer, and subsequently reducing the expression of IL-8 signaling in lipopolysaccharide-stimulated CRC cells [85][86][87][88]90,92].…”

Section: Direct and Gut-microbiota-modulating Mechanisms Of Action Ofmentioning

confidence: 99%

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

et al. 2020

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Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial composition and a notably higher abundance of putative oral bacteria in colonic tumors. Many experimental studies and preclinical evidence propose that dietary polyphenols have a relevant role in CRC development and progression, mainly attributed to their immunomodulatory activities. Furthermore, polyphenols can modulate oral and gut microbiota, and in turn, intestinal microbes catabolize polyphenols to release metabolites that are often more active and better absorbed than the original phenolic compounds. The current study aimed to review and summarize current knowledge on the role of microbiota and the interactions between dietary polyphenols and microbiota in relation to CRC development. We have highlighted the mechanisms by which dietary polyphenols and/or their microbial metabolites exert their action on the pathogenesis and prevention of CRC as modulators of the composition and/or activity of oral and intestinal microbiota, including novel screening biomarkers and possible nutritional therapeutic implications.

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“…In this line, Bassani et al (2016) of 5-FU, a well-known cytostatic agent (Ramos et al, 2013). In general terms, the decrease of tumor cell viability by OMW has been mainly associated with the presence of Hydroxytyrosol and Hydroxytyrosol-derived compounds (Rosignoli et al, 2016;Rafehi et al, 2012).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Olive mill wastewater as a potential source of antibacterial and anti-inflammatory compounds against the food-borne pathogen Campylobacter

Silván

Pinto-Bustillos

Vásquez-Ponce

et al. 2019

Innovative Food Science & Emerging Technologies

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Phenolics and secoiridoids from crude olive mill wastewater (OMW) were purified using a preparative hybrid separation process: pressure-driven cross-flow membrane micro-(MF) and ultrafiltration (UF) and solid phase extraction (SPE). Five fractions with different contents of these compounds were obtained and their antibacterial activity against several strains of Campylobacter was evaluated. The results showed that the fraction with the highest content of phenolic and secoiridoid compounds had a relevant antibacterial activity against all tested strains with a strain-dependent character. Pre-treatment of LPS-stimulated cells with this fraction decreased the production of nitric oxide (NO), showing its potential as anti-inflammatory agent. Finally, the effect of the same fraction on the viability of human intestinal epithelial cell lines was evaluated. In conclusion, OMW could be useful as a potential source of bioactive compounds against Campylobacter, increasing the valorisation of olive oil by-products.

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Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells

Cited by 40 publications

References 52 publications

Effects of a Phenol-Enriched Purified Extract from Olive Mill Wastewater on Skin Cells

Effects of a Phenol-Enriched Purified Extract from Olive Mill Wastewater on Skin Cells

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

Olive mill wastewater as a potential source of antibacterial and anti-inflammatory compounds against the food-borne pathogen Campylobacter

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