Potential carcinogenicity of some transition metal ions

Dovinová, I.; Vachálková, A; Novotný, Ladislav

doi:10.1007/bf02784276

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Pathological conditions in animals can lead to free radical processes (Kankofer 2002, Szpringer and Lutnicki 2003, Lutnicki et al 2006, Kankofer and Albera 2007. Metal ions are often responsible for the damage and protection of biological systems (Dovinová et al 1999). Fenton and the Fenton-like reactions can play a central role the oxidative stress and can be catalyzed by transition metal ions and their complexes (Naora et al 1987, Kleczkowski et al 2002, Ayensu and Tchounwou 2006, Hud 2008, Mounicou et al 2009, Mü ller 2010.…”

Section: Oxidative Stressmentioning

confidence: 99%

The role of metal ions in biological oxidation - the past and the present

Kleczkowski¹,

Garncarz²

2012

Polish Journal of Veterinary Sciences

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Two theories, one based on the metabolism of inorganic substances, the other on metabolism of organic substances, have played an important role in the explanation of the origin of life. They demonstrate that the original environment of life on Earth was seawater containing micronutrients with structural, metabolic and catalytic activity. It is assumed that the first primitive organisms lived around 3.8 billion years ago and it was also then that the first catalytic reaction involving metal ions occurred. Biological oxidation leading to oxidative stress and cell damage in animals represents one of these types of reactions which are responsible for many animal diseases. The role of prooxidative and antioxidative actions of transition metal ions as well as their neuropathological consequences have therefore been the topic for many research projects. There is hope that metal chelates and antioxidants might prove to be a modern mode of therapy for i.e. neurogenerative diseases. The aim of this review is to show the evolution of scientific knowledge on metal ions, their biological oxidation, and an overview of their role in physiology and in pathological processes.

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