2016
DOI: 10.1111/cea.12870
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Potential blood biomarkers in chronic spontaneous urticaria

Abstract: Summary Chronic spontaneous urticaria (CSU) is a mast cell‐driven disease that is defined as the recurrence of weals, angioedema or both for > 6 weeks due to known or unknown causes. As of yet, disease diagnosis is purely clinical. Objective tools are needed to monitor the activity of CSU and the efficacy of treatment. Recently, several reports have suggested that blood parameters may be considered as potential disease‐related biomarkers. Here, we reviewed available literature on blood biomarkers for CSU diagn… Show more

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Cited by 104 publications
(108 citation statements)
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References 111 publications
(65 reference statements)
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“…To the best of our knowledge, we were the first to assess the set of biomarkers in the same group of CSU patients for predicting response to nsAH. The role of D-dimer and activation of coagulation in CSU pathogenesis is widely discussed (3)(4)(5). Patients with high levels of D-dimer, fibrinogen and/or CRP are shown to have severe CSU (3,5,6) that is in the line with the results of our study.…”
Section: To the Editorsupporting
confidence: 90%
See 1 more Smart Citation
“…To the best of our knowledge, we were the first to assess the set of biomarkers in the same group of CSU patients for predicting response to nsAH. The role of D-dimer and activation of coagulation in CSU pathogenesis is widely discussed (3)(4)(5). Patients with high levels of D-dimer, fibrinogen and/or CRP are shown to have severe CSU (3,5,6) that is in the line with the results of our study.…”
Section: To the Editorsupporting
confidence: 90%
“…Identification of biomarkers for predicting the response to nsAH is necessary for developing an individualized treatment. Total IgE, D-dimer, fibrinogen, ESR and C-reactive protein (CRP) have been previously investigated as potential biomarkers of CSU activity and/or response to treatment (3)(4)(5). Herein, we for the first time evaluated their combination for predicting the outcome of treatment with levocetirizine in CSU patients.…”
Section: To the Editormentioning
confidence: 99%
“…They also found that plasma levels of prothrombin fragment 1 + 2, D‐dimer, and CRP might be predictors of CSU severity. Likewise, a review by Kolkhir et al . found a significant association between values of biomarkers and CSU activity for D‐dimer, CRP, prothrombin fragment 1 + 2, MPV, and IL‐6.…”
Section: Disease Activity and Disease Control In Chronic Urticariamentioning
confidence: 91%
“…Current evidence supports the possible contribution of other pathomechanisms, including the dysregulation of intracellular signalling pathways in basophils and mast cells, an abnormal innate immunity response, and the simultaneous activation of inflammatory response and coagulation system (2)(3)(4). With regard to the last aspect in more detail, significantly increased circulating levels of inflammatory markers [such as C-reactive protein (CRP) and interleukin (IL)-6], fibrin degradation products and D-dimer have been associated with the active phase of CSU, in correlation with disease severity (5). The activation of coagulation in CSU is likely to take place through the involvement of eosinophils and tissue factor pathway with thrombin generation and increased vascular permeability (6).…”
Section: Chronic Spontaneous Urticariamentioning
confidence: 99%