Potential bioreductive alkylating agents. 4. Inhibition of coenzyme Q enzyme systems by lipoidal benzoquinone and naphthoquinone derivatives

Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives

“…Toxic properties of these natural compounds leaded medicinal chemists to synthesize new derivatives including a,b-unsaturated carbonyl moiety as a pharmacophoric group (Figure 2), which are thought to have high antitumor activity with low cytotoxicity 10 . Quinone methide moiety is also an important anticancer active group, which has a,b-unsaturated carbonyl structure [11][12][13] . In studies, indole, benzimidazole and quinazoline rings have been used as precursors of quinone methides because of their excessive reactivity [14][15][16][17] .…”

Total Synthesis of (±)-Hasubanonine

“…The syntheses of 5 and 6 are shown in Scheme . Nitration of 4-benzyloxy-2,3-dimethoxybenzaldehyde ( 7 , available in two steps from commercially available 2,3-dimethoxyphenol) afforded 8 . A sequence of nitro reduction, diazotization, and iodination delivered aryl iodide 5 in 41% yield from the nitro compound.…”