Potential biomarkers for predicting the overall survival outcome of kidney renal papillary cell carcinoma: an analysis of ferroptosis-related LNCRNAs

Abstract

Background Kidney renal papillary cell carcinoma (KIRP) is a dangerous cancer, which accounts for 15–20% of all kidney malignancies. Ferroptosis is a rare kind of cell death that overcomes medication resistance. Ferroptosis-related long non-coding RNAs (LNCRNAs) in KIRP, remain unknown. Method We wanted to express how ferroptosis-related LNCRNAs interact with immune cell infiltration in KIRP. Gene set enrichment analysis in the GO and KEGG databases were used to explore gene expression enrichment. The prognostic model was constructed using Lasso regression. In addition, we also analyzed the modifications in the tumor microenvironment (TME) and immunological association. Result The expression of LNCRNA was closely connected to the ferroptosis, according to co-expression analyses. CASC19, AC090197.1, AC099850.3, AL033397.2, LINC00462, and B3GALT1-AS1 were found to be significantly increased in the high-risk group, indicating that all of these markers implicates the malignancy processes for KIRP patients and may be cancer-promoting variables. LNCTAM34A and AC024022.1 were shown to be significantly elevated in the low-risk group; these might represent as the KIRP tumor suppressor genes. According to the TCGA, CCR, and inflammation-promoting genes were considered to be significantly different between the low-risk and high-risk groups. The expression of CD160, TNFSF4, CD80, BTLA, and TNFRSF9 was different in the two risk groups. Conclusion LNCRNAs associated with ferroptosis were linked to the occurrence and progression of KIRP. Ferroptosis-related LNCRNAs and immune cell infiltration in the TME may be potential biomarkers in KIRP that should be further investigated.

The Roles of Ferroptosis-related Long Non-coding RNAs in Urologic Cancers

“…The study found that 7 different frlncRNAs had strong link to the prognosis of patients with PRCC [16]. The frlncRNAs CASC19, AC090197.1, AC099850.3, AL033397.2, LINC00462, and B3GALT1-AS1 were designated as oncogenes in PRCC, whereas LNCTAM34A and AC024022.1 are recognized as tumor suppressor genes in PRCC [17]. These studies have demonstrated that frlncRNAs are associated with the prognosis of kidney cancers, and play diverse roles in cancer progression.…”

“…Wu et al found some frlncRNAs targeting inflammation-and immune-promoting genes viz. CD160, TNFSF4, CD80, BTLA, and TNFRSF9 differentially expressed in the high-and low-risk groups with PRCC [17]. It indicates that similar and dissimilar frlncRNAsrelated immune genes were found in different studies, and the accurate molecular functions still needs to further verification.…”

Long non-coding RNAs enable precise diagnosis and prediction of early relapse after nephrectomy in patients with renal cell carcinoma

“…There are however, several other lncRNAs in our panel, which are not frequent in similar RCC-focused studies. For example AZGP1P1 has been associated only with prognosis in breast cancer (Liu et al 2019), LINC00462, which has been associated with ferroptosis according to one recent work (Wu et al 2022b), LINC00955 without any other evidence, RMST, which is known to be involved in the development of other tumors, but not RCC (Chen et al 2022) and similarly ZNF667-AS1, also known as MORT (Vrba and Futscher 2018).…”

Multi-omics analysis of renal clear cell carcinoma progression

“…Studies by Kim et al have shown a relationship between BCR gene expression and RCC [28, 29]. Gene expression of BCR was also upregulated in KIRP, a renal cancer closely related to RCC [30]. B3GALT1 is involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins, and has been found to be involved in cervical adenosquamous carcinoma [31].…”