Potential Biomarkers for Personalized Radiation Therapy for Patients with Uterine Cervical Cancer

Moreno‐Acosta, Pablo; Carrillo, Shyrly; Gamboa, Óscar; Mayorga, Diana; Romero‐Rojas, Alfredo; Vallard, Alexis; Rancoule, C.; Magné, Nicolas

doi:10.1007/978-3-030-02701-8_13

Cited by 3 publications

(3 citation statements)

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“…The proteins hTERT, IGF-1R, E6 and E7 of HPV16 and HMGA2 have been proposed as prognostic markers of CC by several others (1,2,34,41,(55)(56)(57)(58)(59)(60), and associated with the response to radiotherapy treatment (1,2,41). Nevertheless, the presence of high-risk HPV (a causative factor) with these putative markers shadows the relationship between them.…”

Section: Discussionmentioning

confidence: 99%

hTERT and IGF-1R Proteins Expression in Response to Treatment in Patients with HPV Alpha 9-Positive Cervical Cancer

et al. 2023

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Human papillomavirus (HPV) infection is strongly associated with cervical cancer (CC). Genomic alterations caused by viral infection and subsequent dysregulation of cellular metabolism under hypoxic conditions could influence the response to treatment. We studied a possible influence of IGF-1Rβ, hTERT, HIF1α, GLUT1 protein expression, HPV species presence and relevant clinical parameters on the response to treatment. In 21 patients, HPV infection and protein expression were detected using GP5+/GP6+PCR-RLB and immunohistochemistry, respectively. The worse response was associated with radiotherapy alone compared with chemoradiotherapy (CTX-RT), anemia and HIF1α expression. HPV16 type was the most frequent (57.1%) followed by HPV-58 (14.2%) and HPV-56 (9.5%). The HPV alpha 9 species was the most frequent (76.1%) followed by alpha 6 and alpha 7. IGF-1Rβ (85.7%), HIF1α (61.9%), GLUT1 (52.3%), and hTERT expression [cytoplasm and nucleus (90.4%)] were detected. The MCA factorial map showed different relationships, standing out, expression of hTERT and alpha 9 species HPV, expression of hTERT and IGF-1Rβ expression [Fisher's exact test (P = 0.04)]. A slight trend of association was observed between, GLUT1 and HIF1 α expression, hTERT and GLUT1 expression. A noteworthy finding was the subcellular localization of hTERT in the nucleus and cytoplasm of CC cells and its possible interaction with IGF-1R in presence of HPV alpha 9 species. Our findings suggest that the expression of HIF1α, hTERT, IGF-1Rβ and GLUT1 proteins that interact with some HPV species may contribute to cervical cancer development, and the modulation of treatment response.

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Section: Discussionmentioning

confidence: 99%

hTERT and IGF-1R Proteins Expression in Response to Treatment in Patients with HPV Alpha 9-Positive Cervical Cancer

et al. 2023

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“…It promoted insidious cell proliferation and anomalous survival in preneoplastic tissues, with a fostered effect in neoplastic tissues [ 32 ]. Interestingly, it was suggested that HPV-16 interacted with IGF1R in cervical tumors, resulting in radio resistance [ 13 , 14 , 33 , 34 ]. Moreover, Zacapala-Gómez et al suggested that the expression of E6 variants AA-c and E-G350 induced overexpression of IGF1R [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…IGF1R overexpression and IGF1R detection by IHC were associated with a poor prognosis. Therefore, they turned into possible interesting biomarkers of resistance of treatments [ 13 , 14 , 34 ]. Thus, analyses of biological and molecular changes (performed on preneoplastic lesions and locally advanced cancer) could be considered valuable biomarkers, reflecting the current or future aggressiveness of the disease.…”

Section: Discussionmentioning

confidence: 99%

Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer

Moreno‐Acosta

Romero‐Rojas

Vial

et al. 2020

Case Reports in Obstetrics and Gynecology

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This article is a preliminary investigational study that is aimed at giving hints about the interesting biomarkers involved in the transition process from low-grade cervix lesion to invasive cervical cancer. Our study focuses on the risk factors and tumour molecular changes in one patient. First in 1986, she was diagnosed a preinvasive cervix lesion. Then, 16 years later, she was diagnosed an invasive cervical cancer. The 2002 diagnosis was a squamous cell carcinoma of the cervix, stage IIIB (FIGO), whereas in 1986, she had been diagnosed a high-grade squamous intraepithelial cervical lesion. Retrospectively, the analysis of samples of preneoplastic lesions and invasive cervical cancer confirmed the histopathological diagnoses and detected the presence of HPV type and HPV-16 variants, as well as the overexpression of proteins such as hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1. Finally, the Arg72Pro polymorphism was detected in TP53. The role of high-risk HPV and HPV-16 variants and of hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1 variations seemed confirmed in the development and progression of cervical cancer. As a result, analyzing the molecular changes in one and same tumour that progresses from a low-grade cervix lesion to invasive cervical cancer could provide valuable information in order to improve detection, diagnosis, and treatment in the future.

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Human Papilloma Virus (HPV) - A Threat to Women Worldwide: Emerging Solutions for Cervical Cancer

Mp¹,

Vmb²,

Dd³

2021

IJCRR

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Potential Biomarkers for Personalized Radiation Therapy for Patients with Uterine Cervical Cancer

Cited by 3 publications

References 60 publications

hTERT and IGF-1R Proteins Expression in Response to Treatment in Patients with HPV Alpha 9-Positive Cervical Cancer

hTERT and IGF-1R Proteins Expression in Response to Treatment in Patients with HPV Alpha 9-Positive Cervical Cancer

Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer

Human Papilloma Virus (HPV) - A Threat to Women Worldwide: Emerging Solutions for Cervical Cancer

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