Potential biomarker in serum for predicting susceptibility to type 2 diabetes mellitus: Free fatty acid 22:6

Ma, Yong; Xiong, Jianyu; Zhang, Xueting; Qiu, Tongtong; Pang, Huai; Li, Xue; Zhu, Jiaojiao; Wang, Jingzhou; Pan, Chongge; Yang, Xin; Chu, Xiaolong; Yang, Bingqi; Wang, Cuizhe; Zhang, Jun

doi:10.1111/jdi.13443

Cited by 14 publications

(9 citation statements)

References 39 publications

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“…Finally, in obese subjects, in addition to the altered pattern of adipokines secretion, AT releases greater quantities of FFAs [ 144 ], which are associated with insulin resistance and lipotoxicity [ 144 , 145 ]. In particular, while some studies report an increase in the levels of SFAs (i.e., palmitic acid [ 146 ], decanoic acid, and caprylic acid [ 147 ]), in obese subjects, unsaturated fatty acids levels have been found to be both decreased (i.e., oleic acid [ 147 ] and linoleic acid [ 146 , 148 ]) and increased (i.e., palmitoleic acid [ 146 , 149 ], dihomo-gamma-linolenic acid [ 149 ], and docosaesaenoic acid [ 147 ]).…”

Section: Dysfunctional Adipose Tissue In Obesity: Alteration Of the A...mentioning

confidence: 99%

Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes

Biondi

Marrano

Borrelli

et al. 2022

IJMS

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The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells and their ability to secure adequate insulin secretion, represents a key mechanistic factor leading to the onset of type 2 diabetes (T2D). Obesity is recognised as a leading cause of β-cell loss and dysfunction and a risk factor for T2D. The natural history of β-cell failure in obesity-induced T2D can be divided into three steps: (1) β-cell compensatory hyperplasia and insulin hypersecretion, (2) insulin secretory dysfunction, and (3) loss of β-cell mass. Adipose tissue (AT) secretes many hormones/cytokines (adipokines) and fatty acids that can directly influence β-cell function and viability. As this secretory pattern is altered in obese and diabetic patients, it is expected that the cross-talk between AT and pancreatic β-cells could drive the maintenance of the β-cell integrity under physiological conditions and contribute to the reduction in the β-cell functional mass in a dysmetabolic state. In the current review, we summarise the evidence of the ability of the AT secretome to influence each step of β-cell failure, and attempt to draw a timeline of the alterations in the adipokine secretion pattern in the transition from obesity to T2D that reflects the progressive deterioration of the β-cell functional mass.

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Section: Dysfunctional Adipose Tissue In Obesity: Alteration Of the A...mentioning

confidence: 99%

Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes

Biondi

Marrano

Borrelli

et al. 2022

IJMS

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“…It should be noted that some of biomarkers we found in this work, FFA (16:1), FFA (20:5), TAG (50:2), TAG (52:1), TAG (52:3), TAG (52:4), TAG (52:5), TAG (54:3), TAG (54:4), TAG (54:5), and TAG (56:6), also have shown changed distinctly in patients during the onset and progression of metabolic-associated diseases, such as MAFLD, 47 type 2 diabetes, 48 obesity, 8 and cardiovascular disease. 49 Nevertheless, these previous studies with traditional approaches found only a single indicator or a few indicators at a time.…”

Section: Sbp Alleviates Metabolic Disorders In Long-term Hfd-fed Mice...mentioning

confidence: 99%

Sea Buckthorn Polyphenols Alleviate High-Fat-Diet-Induced Metabolic Disorders in Mice via Reprograming Hepatic Lipid Homeostasis Owing to Directly Targeting Fatty Acid Synthase

Yuan,

Zhang,

Fang

et al. 2024

J. Agric. Food Chem.

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Our previous studies found that Sea Buckthorn polyphenols (SBP) extract inhibits fatty acid synthase (FAS) in vitro. Thus, we continued to explore possible effects and underlying mechanisms of SBP on complicated metabolic disorders in long-term high-fat-diet (HFD)-fed mice. To reveal that, an integrated approach was developed in this study. Targeted quantitative lipidomics with a total of 904 unique lipids mapping contributes to profiling the comprehensive features of disarranged hepatic lipid homeostasis and discovering a set of newfound lipid-based biomarkers to predict the occurrence and indicate the progression of metabolic disorders beyond current indicators. On the other hand, technologies of intermolecular interactions characterization, especially surface plasmon resonance (SPR) assay, contribute to recognizing targeted bioactive constituents present in SBP. Our findings highlight hepatic lipid homeostasis maintenance and constituent−FAS enzyme interactions, to provide new insights that SBP as a functional food alleviates HFD-induced metabolic disorders in mice via reprograming hepatic lipid homeostasis caused by targeting FAS, owing to four polyphenols directly interacting with FAS and cinaroside binding to FAS with good affinity.

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“…Excess FFAs and hyperglycemia can lead to the impairment of beta‐cells by inducing endoplasmic reticulum (ER) stress through activation of the apoptotic unfolded response (UPR) pathways. The stress induced by excess saturated FFAs activates the UPR pathway, leading to inhibition of the sarco/ER Ca2+ ATPase (SERCA), activation of IP3 receptors, or direct damage of ER homeostasis 30 . Insulin resistance, marked by heightened glucose production in the liver and reduced glucose utilization in the liver, muscles, and adipose tissue, is a key player in T2DM.…”

Section: Pathophysiology Of Diabetesmentioning

confidence: 99%

Transform diabetes care with precision medicine

Kannan,

Chellappan,

Kow

et al. 2023

Health Science Reports

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Background and AimsDiabetes is a global concern. This article took a closer look at diabetes and precision medicine.MethodsA literature search of studies related to the use of precision medicine in diabetes care was conducted in various databases (PubMed, Google Scholar, and Scopus).ResultsPrecision medicine encompasses the integration of a wide array of personal data, including clinical, lifestyle, genetic, and various biomarker information. Its goal is to facilitate tailored treatment approaches using contemporary diagnostic and therapeutic techniques that specifically target patients based on their genetic makeup, molecular markers, phenotypic traits, or psychosocial characteristics. This article not only highlights significant advancements but also addresses key challenges, particularly focusing on the technologies that contribute to the realization of personalized and precise diabetes care.ConclusionFor the successful implementation of precision diabetes medicine, collaboration and coordination among multiple stakeholders are crucial.

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Potential biomarker in serum for predicting susceptibility to type 2 diabetes mellitus: Free fatty acid 22:6

Cited by 14 publications

References 39 publications

Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes

Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes

Sea Buckthorn Polyphenols Alleviate High-Fat-Diet-Induced Metabolic Disorders in Mice via Reprograming Hepatic Lipid Homeostasis Owing to Directly Targeting Fatty Acid Synthase

Transform diabetes care with precision medicine

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