Potential bioactive compounds of medicinal plants against new Coronavirus (SARS-CoV-2): A review

Manzano, Patricia; Tivillin, J. P. P.; Chóez-Guaranda, Iván; Lucas, Alexandra; Orellana‐Manzano, Andrea; Rastrelli, Luca

doi:10.21931/rb/2021.06.01.30

Cited by 12 publications

(5 citation statements)

References 49 publications

(48 reference statements)

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“…Due to the remoteness, poverty, and lack of modern healthcare facilities, the people of this region strongly believe in this age-old traditional cure system 3 , 39 . In the context of the pandemic Coronavirus disease (COVID-19), medicinal plants are found to be very effective 47 – 49 . Many people affected by the COVID-19 have recovered without hospitalization as they use medicinal plants of their region.…”

Section: Discussionmentioning

confidence: 99%

Predicting phytochemical diversity of medicinal and aromatic plants (MAPs) across eco-climatic zones and elevation in Uttarakhand using Generalized Additive Model

Tiwari

Kewlani

Gaira

et al. 2023

Sci Rep

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The present study uses a systematic approach to explore the phytochemical composition of medicinal plants from Uttarakhand, Western Himalaya. The phytochemical composition of medicinal plants was analyzed based on (i) the presence of different chemical groups and (ii) bioactive compounds. The Generalized Additive Model (GAM) analysis was used to predict the occurrence of chemical groups and active compounds across different eco-climatic zones and the elevation in Uttarakhand. A total of 789 medicinal plants represented by 144 taxonomic families were screened to explore the phytochemical diversity of the medicinal plants of Uttarakhand. These medicinal plant species are signified in different life forms such as herbs (58.86%), shrubs (18.24%), trees (17.48%), ferns (2.38%), and climbers (2.13%). The probability of occurrence of the chemical groups found in tropical, sub-tropical, and warm temperate eco-climatic zones, whereas active compounds have a high Probability towards alpine, sub-alpine, and cool temperate zones. The GAM predicted that the occurrence of species with active compounds was declining significantly (p < 0.01), while total active compounds increased across elevation (1000 m). While the occurrence of species with the chemical group increased, total chemical groups were indicated to decline with increasing elevation from 1000 m (p < 0.000). The current study is overwhelmed to predict the distribution of phytochemicals in different eco-climatic zones and elevations using secondary information, which offers to discover bioactive compounds of the species occurring in the different eco-climatic habitats of the region and setting the priority of conservation concerns. However, the study encourages the various commercial sectors, such as pharmaceutical, nutraceutical, chemical, food, and cosmetics, to utilize unexplored species. In addition, the study suggests that prioritizing eco-climatic zones and elevation based on phytochemical diversity should be a factor of concern in the Himalayan region, especially under the climate change scenario.

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Section: Discussionmentioning

confidence: 99%

Predicting phytochemical diversity of medicinal and aromatic plants (MAPs) across eco-climatic zones and elevation in Uttarakhand using Generalized Additive Model

Tiwari

Kewlani

Gaira

et al. 2023

Sci Rep

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“…In the study of Lau K.-M et al (2018) [6], an oral dose of 250 mg/kg/day of Houttuynia cordata leaf extract could be considered an unobserved side effect level in rats for 28 days. According to Vietnamese Pharmacopeia V [10], Morus alba leaf doses range from 5 g to 12 g in the decoction dosage form.…”

Section: Methods 221 Research On the Formulation Of Hard Capsules Con...mentioning

confidence: 99%

“…In the anti-viral aspect, Houttuynia cordata exhibited significant inhibitory effects on SARS-CoV 3C-like protease and RNA-dependent RNA polymerase [3], [5]. Santana et al (2021) presented a list of different bioactive compounds against SARS-CoV-2 for many medicinal plant species, of which the active ingredient in Morus alba was considered to have great potential [6]. A study by Arm Adel et al (2022) showed that papaya extract had significant effects in the treatment of dengue virus with antiviral, immunomodulatory, and cytokine storm-reducing properties, so it would reduce inflammatory conditions caused by COVID-19 [7], [8].…”

Section: Introductionmentioning

confidence: 99%

Research on Formulation of Hard Capsules Containing Extracts of Houttuynia Cordata Thumb (Saururaceae), Morus Alba L. (Moraceae), and Carica Papaya L. (Caricaceae)

Huynh,

Nguyen,

et al. 2023

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Background: previous studies have demonstrated that Houttuynia cordata Thumb (Saururaceae), Morus alba L. (Moraceae), and Carica papaya L. (Caricaceae) are effective against various viruses, especially the SARS-CoV-2 virus. In Vietnam, even though the three of these plant species are grown quite popularly and are pretty commonly consumed by residents regularly, there have not been any applications to the dosage forms to promote their full potential effects and make these dosage forms easy to use and preserve. Furthermore, no research has been conducted on a capsule form that combines all three of these medicinal herbs. Objectives: the research focuses on the composition of a hard capsule formula containing the extracts of Houttuynia cordata, Morus alba, and Carica papaya as well as the development of testing standards for prepared hard capsules. Materials and methods: the ratio of adsorbents and fillers in the formula was investigated so that the granules had low moisture, a suitable flow rate, and the appropriate apparent density for packaging; standards for testing capsules were developed according to current regulations. Results: the selected adsorbent was light MgCO3, with a ratio of plant extract: filler: adsorbent of 10: 5: 0.5 and a ratio of Avicel: Starch 1500 of 1: 3. Conclusions: a hard capsule containing medicinal plant extract was formulated with a moisture content of < 5% and well-flowing granules that had the suitable apparent density for packing the capsule size of 0. Capsules met standards in terms of appearance, weight uniformity, disintegration, heavy metal and microorganisms, with a quercetin content of 74.45 ± 0.23 mg. The result of the study is considered one of the most essential bases for further research on determining the effectiveness of medicines derived from medicinal plants and applied to support the treatment of COVID-19, which is still happening in a quite complicated way at the moment.

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“…The use of co-adjuvants, such as high doses of vitamin D [ 41 ], intravenous vitamin C [ 42 ], zinc supplements [ 43 ], or medicinal plants and their active components, has been proposed as a supplementary treatment [ 44 ]. They are under investigation, but none have been accepted as being a definitive treatment.…”

Section: Introductionmentioning

confidence: 99%

Can Probiotics, Particularly Limosilactobacillus fermentum UCO-979C and Lacticaseibacillus rhamnosus UCO-25A, Be Preventive Alternatives against SARS-CoV-2?

Valdebenito-Navarrete

Fuentes-Barrera

Smith

et al. 2023

Biology

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COVID-19, an infection produced by the SARS-CoV-2 virus in humans, has rapidly spread to become a high-mortality pandemic. SARS-CoV-2 is a single-stranded RNA virus characterized by infecting epithelial cells of the intestine and lungs, binding to the ACE2 receptor present on epithelial cells. COVID-19 treatment is based on antivirals and antibiotics against symptomatology in addition to a successful preventive strategy based on vaccination. At this point, several variants of the virus have emerged, altering the effectiveness of treatments and thereby attracting attention to several alternative therapies, including immunobiotics, to cope with the problem. This review, based on articles, patents, and an in silico analysis, aims to address our present knowledge of the COVID-19 disease, its symptomatology, and the possible beneficial effects for patients if probiotics with the characteristics of immunobiotics are used to confront this disease. Moreover, two probiotic strains, L. fermentum UCO-979C and L. rhamnosus UCO-25A, with different effects demonstrated at our laboratory, are emphasized. The point of view of this review highlights the possible benefits of probiotics, particularly those associated with immunomodulation as well as the production of secondary metabolites, and their potential targets during SARS-CoV-2 infection.

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Potential bioactive compounds of medicinal plants against new Coronavirus (SARS-CoV-2): A review

Cited by 12 publications

References 49 publications

Predicting phytochemical diversity of medicinal and aromatic plants (MAPs) across eco-climatic zones and elevation in Uttarakhand using Generalized Additive Model

Predicting phytochemical diversity of medicinal and aromatic plants (MAPs) across eco-climatic zones and elevation in Uttarakhand using Generalized Additive Model

Research on Formulation of Hard Capsules Containing Extracts of Houttuynia Cordata Thumb (Saururaceae), Morus Alba L. (Moraceae), and Carica Papaya L. (Caricaceae)

Can Probiotics, Particularly Limosilactobacillus fermentum UCO-979C and Lacticaseibacillus rhamnosus UCO-25A, Be Preventive Alternatives against SARS-CoV-2?

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