Potential Benefit of Scanned Proton Beam versus Photons as Adjuvant Radiation Therapy in Breast Cancer

Flejmer, Anna M.; Nyström, Petra Witt; Dohlmar, Frida; Josefsson, Dan; Daşu, Alexandru

doi:10.14338/ijpt-14-00013.1

Cited by 10 publications

(12 citation statements)

References 31 publications

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“…This is quite relevant for breast cancer patients where radiotherapy has been shown to improve local control and overall survival [1], increasing the concern for late cardiopulmonary toxicity in long-term survivors. Several studies have investigated the potential of scanned proton beams for breast radiation therapy showing that the technique could increase target conformity and thus reduce doses to the normal tissues of interest [2][3][4][5][6]. The finite range of protons and the strong dependence of their interaction properties to the medium make proton dose distributions quite sensitive to physiological motion raising concerns regarding the impact of breathing on the dose distributions [7].…”

Section: Introductionmentioning

confidence: 99%

Impact of physiological breathing motion for breast cancer radiotherapy with proton beam scanning – An in silico study

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Impact of physiological breathing motion for breast cancer radiotherapy with proton beam scanning – An in silico study

et al. 2017

Self Cite

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“…Such findings are indicative of a potential benefit in using proton radiotherapy for adjuvant radiotherapy of BC patients, especially when risk factors for cardiac complications are present [80].…”

Section: Breast Cancer (Bc)mentioning

confidence: 86%

“…The sparing effects of proton radiotherapy on critical organs is particularly apparent in cases of left-sided BC where using IMPT, as compared with IMRT, allowed a 20-fold reduction of heart dose and for the left anterior descendens (LAD) artery region (a lower arm of the left coronary artery), which is a critical structure in the development of late cardiac complications [67,[75][76][77][78][79][80]. Such findings are indicative of a potential benefit in using proton radiotherapy for adjuvant radiotherapy of BC patients, especially when risk factors for cardiac complications are present [80].…”

Section: Breast Cancer (Bc)mentioning

confidence: 99%

Proton radiotherapy for treating the most common carcinomas

Sas-Korczyńska

Jakubowicz²,

Reinfuss³

2017

Nowotwory. Journal of Oncology

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A literature review is presented on proton radiotherapy when used for treating the most common carcinoma types such as cancer of the lung, breast and prostate. This is based on analytic parameters of dosimetry and clinical outcomes (efficacy and toxicity), along with studies on cost-effectiveness as compared to those achieved by conventional photon radiotherapy. NOWOTWORY J Oncol 2016; 66, 5: 396-402

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“…In this study, these two parameters were the most appropriate when using proton therapy compared with the other techniques. Fleimer et al [ 37 ] checked one of the most frequently used proton radiotherapy techniques, scanned proton beams. They showed that it could be used to treat multifocal or lobular disease, as, in these cases, cold spots in the PTV usually appear.…”

Section: Toxicity Of Breast Cancer Proton Therapymentioning

confidence: 99%

Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy

Musielak

Suchorska

Fundowicz

et al. 2021

JPM

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The toxicity of radiotherapy is a key issue when analyzing the eligibility criteria for patients with breast cancer. In order to obtain better results, proton therapy is proposed because of the more favorable distribution of the dose in the patient’s body compared with photon radiotherapy. Scientific groups have conducted extensive research into the improved efficacy and lower toxicity of proton therapy for breast cancer. Unfortunately, there is no complete insight into the potential reasons and prospects for avoiding undesirable results. Cardiotoxicity is considered challenging; however, researchers have not presented any realistic prospects for preventing them. We compared the clinical evidence collected over the last 20 years, providing the rationale for the consideration of proton therapy as an effective solution to reduce cardiotoxicity. We analyzed the parameters of the dose distribution (mean dose, Dmax, V5, and V20) in organs at risk, such as the heart, blood vessels, and lungs, using the following two irradiation techniques: whole breast irradiation and accelerated partial breast irradiation. Moreover, we presented the possible causes of side effects, taking into account biological and technical issues. Finally, we collected potential improvements in higher quality predictions of toxic cardiac effects, like biomarkers, and model-based approaches to give the full background of this complex issue.

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Potential Benefit of Scanned Proton Beam versus Photons as Adjuvant Radiation Therapy in Breast Cancer

Cited by 10 publications

References 31 publications

Impact of physiological breathing motion for breast cancer radiotherapy with proton beam scanning – An in silico study

Impact of physiological breathing motion for breast cancer radiotherapy with proton beam scanning – An in silico study

Proton radiotherapy for treating the most common carcinomas

Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy

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