Potential benefit from the implementation of the Kaiser Permanente neonatal early-onset sepsis calculator on clinical management of neonates with presumed sepsis

Kopsidas, Ioannis; Molocha, Nafsika-Maria; Kourkouni, Εleni; Coffin, Susan; Gkentzi, Despoina; Chorianopoulou, Evangelia; Dimitriou, Gabriel; Kapetanaki, Anastasia; Karavana, Georgia; Lithoxopoulou, Maria; Polychronaki, Maria; Roilides, Emmanuel; Triantafyllidou, Pinelopi; Triantafyllou, Christos; Tsopela, Grammatiki-Christina; Tsouvala, Emmanouela; Τσολιά, Μαρία; Zaoutis, Theoklis E.; Spyridis, Νikos; Papaevangelou, Vassiliki; Tsintoni, Asimina; Soubasi-Griva, Vasiliki; Riti, Marianna Skordala-; Theodoraki, Maria E.

doi:10.1007/s00431-021-04282-x

Cited by 2 publications

(1 citation statement)

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“… 32–35 Comparably, a study from Norway reported EOS incidence of 0.97/1000 live births between 1996–2018. 36 Whereas, a study in Greece reported a weighted EOS incidence rate of 1.8/1000 live births, 37 indicating some variability in the HIC data. A higher EOS was similarly reported in a large study among preterm infants conducted in China (upper-middle income) between 2015–2018 (n=27,532 enrolled infants) with an incidence of 9.7/1000 live births.…”

Section: Epidemiology Of Neonatal Sepsis In Lmics: a Summarymentioning

confidence: 99%

Early-Onset Neonatal Sepsis in Low- and Middle-Income Countries: Current Challenges and Future Opportunities

Sands

Spiller

Thomson

et al. 2022

IDR

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Neonatal sepsis is defined as a systemic infection within the first 28 days of life, with early-onset sepsis (EOS) occurring within the first 72h, although the definition of EOS varies in literature. Whilst the global incidence has dramatically reduced over the last decade, neonatal sepsis remains an important cause of neonatal mortality, highest in low- and middle-income countries (LMICs). Symptoms at the onset of neonatal sepsis can be subtle, and therefore EOS is often difficult to diagnose from clinical presentation and laboratory testing and blood cultures are not always conclusive or accessible, especially in resource limited countries. Although the World Health Organisation (WHO) currently advocates a ß-lactam, and gentamicin for first line treatment, availability and cost influence the empirical antibiotic therapy administered. Antibiotic treatment of neonatal sepsis in LMICs is highly variable, partially caused by factors such as cost of antibiotics (and who pays for them) and access to certain antibiotics. Antimicrobial resistance (AMR) has increased considerably over the past decade and this review discusses current microbiology data available in the context of the diagnosis, and treatment for EOS. Importantly, this review highlights a large variability in data availability, methodology, availability of diagnostics, and aetiology of sepsis pathogens.

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Section: Epidemiology Of Neonatal Sepsis In Lmics: a Summarymentioning

confidence: 99%