Potential association of rheumatic diseases with bone mineral density and fractures: a bi-directional mendelian randomization study
Chen-xuan Hong,
Yan-zheng Pan,
Feng-bo Dai
Abstract:Background
Previous studies have implicated rheumatoid arthritis as an independent risk factor for bone density loss. However, whether there is a causal relationship between rheumatic diseases and bone mineral density (BMD) and fractures is still controversial. We employed a bidirectional Mendelian analysis to explore the causal relationship between rheumatic diseases and BMD or fractures.
Methods
The rheumatic diseases instrumental variables (IVs)… Show more
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