Potential Applications of Photoacoustic Imaging in Early Cancer Diagnosis and Treatment

Huaqin, 吴华钦 Wu; Haoyu, 王昊宇 Wang; Wenming, 谢文明 Xie; Zhifang, 李志芳 Li; Shulian, 吴淑莲 Wu; Hui, 李晖 Li

doi:10.3788/lop56.070001

Cited by 3 publications

(2 citation statements)

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“…Therefore, to better diagnose and treat endometrial cancer [8][9] , it must be diagnosed and treated promptly at an early stage or before malignant lesions are present. In the early detection of endometrial cancer tumor tissue, photoacoustic imaging [10][11] can be used in combination with hysteroscopy [3] , which mainly involves laser [12][13] coupling to the light source end of the hysteroscope and entering the uterine cavity through the hysteroscopic viewing channel to excite the tumor tissue in the uterine cavity to produce ultrasound, thus detecting an ultrasound signal different from that of normal tissue and thus making a diagnosis. After literature research, no application of pulsed laser coupling [14][15] through the hysteroscopic viewing channel for early endometrial cancer detection has been found.…”

Section: Introductionmentioning

confidence: 99%

Optimization design of the coupling scheme of the pulse laser output through the hysteroscope observation channel

Wang

Zou

et al. 2023

Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023)

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Photoacoustic imaging is an imaging technology which combines the advantages of high-resolution optical imaging and deep detection depth of acoustic imaging. Photoacoustic imaging combined with hysteroscopy may be a new diagnostic technique for endometrial cancer. However, the energy loss after pulsed laser passing through the hysteroscope is very large. Therefore, the energy of pulsed laser after hysteroscopy based on photoacoustic imaging is worth further discussion. A coupling Program of pulsed laser and hysteroscope based on the optical path of pulsed laser and hysteroscope was designed in this paper. The Program was optimized by ZEMAX simulation, and then the optimal effect of pulsed laser observation through hysteroscopy was verified by phantom experiment. The results show that the pulsed laser can obtain better photoacoustic signals after passing through our coupling module. This method is expected to be applied to the detection of endometrial diseases in clinic.

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Section: Introductionmentioning

confidence: 99%

Optimization design of the coupling scheme of the pulse laser output through the hysteroscope observation channel

Wang

Zou

et al. 2023

Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023)

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“…However, traditional medical imaging techniques are either ineffective in diagnosing small lesions in the early stages of tumours or can be harmful to the patient's body. With the continuous development of science and technology, the emergence of photoacoustic imaging technology has shown great hope and research prospects in the non-destructive diagnosis of early tumour tissue [3] .The photon transport theory based on light particles is the most widely used, and the radiative transfer equation (RTE) accurately describes the propagation of light in biological tissues [4] ，The Monte Carlo (MC) method provides an accurate solution for light propagation in weakly absorbing and highly scattering media [5] .The diffusion approximation (DA) is a typical way of using the RTE as a model for forward photon propagation [6] .DA is widely used due to its fast calculation speed and high accuracy. There are currently many finite element software, and the large general purpose finite element analysis software ANSYS is able to analyse non-linear problems very well and is mainly used in the mechanical and nuclear industries [7] ，DA is widely used due to its fast calculation speed and high accuracy.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic-photothermal visualisation of gastric tissues based on COMSOL

Xuke,

Wang,

et al. 2023

Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023)

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Photoacoustic Imaging (PAI) is a non-invasive imaging technology. It breaks through the limitation of shallow imaging depth of traditional optical imaging and low imaging contrast of acoustic imaging. It has a potential wide application in early cancer detection. PAI combined with endoscopy has great significance in the early diagnosis of gastric tumors. However, imaging just obtains the local location information. It cannot obtain the information of any location visually, especially in the process of photothermal therapy. In this paper, COMSOL was employed to simulate the visual model of photoacoustic photothermal imaging of gastric tissue and tumor. The physical processes of photoacoustic imaging such as photothermal strain-ultrasound generated by pulsed laser in stomach were simulated. A complete photoacoustic model was established through the coupling of each physical field. Firstly, a simplified gastric tissue model was constructed, and physical parameters were set for grid division. Then several physical field modules in COMSOL were coupled. The light distribution, temperature change and photoacoustic signal generated by thermal expansion during the propagation of light in biological tissues were obtained by simulation. The simulation results showed that the distribution of light in gastric tumor was significantly lower than that around the stomach. The tumor absorbs more light energy, resulting in a significantly higher temperature than surrounding stomach tissue. The photoacoustic signal of thermal expansion caused by laser irradiation of biological tissue was obtained. This study is helpful to understand the propagation and interaction of light in normal tissues and gastric tumors. It also provides a certain reference for the research and application of photoacoustic imaging in gastric cancer.

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Directional transmission of ultra-high frequency acoustic signals based on metamaterial structure

Han

Yang

et al. 2019

AIP Advances

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Cell photoacoustic detection of acoustic signals has serious problems of transmission loss and difficulty in acquisition. Based on the acoustic transmission characteristics of acoustic supermaterials, the acoustic wave directional transmission model is designed using COMSOL software, and a finite element simulation experiment was carried out. Experiments show that the model designed in this paper has good sound wave focusing and acoustic wave directional transmission effects. According to the specific application in different environments, this paper designs a variety of transmission models with different structures and carries out comparative experiments to verify the influence of complex model structures on the directional transmission of sound waves. At the same time, the experimental analysis of the acoustic wave directional transmission effect of the model under different frequency segments is carried out, and the possibility of acoustic wave logic operation is verified. Models can be applied to high frequency acoustic signal acquisition and sound wave transmission in complex environments. These studies have important significance for the development of cell photoacoustic detection technology and the application of metamaterial structures and have good practical merit.

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Potential Applications of Photoacoustic Imaging in Early Cancer Diagnosis and Treatment

Cited by 3 publications

References 0 publications

Optimization design of the coupling scheme of the pulse laser output through the hysteroscope observation channel

Optimization design of the coupling scheme of the pulse laser output through the hysteroscope observation channel

Photoacoustic-photothermal visualisation of gastric tissues based on COMSOL

Directional transmission of ultra-high frequency acoustic signals based on metamaterial structure

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