Potential Application of a Visible Light-Induced Photocured Hydrogel Film as a Wound Dressing Material

Abstract

The objective of this work was to prepare hydrogel films, as semi-interpenetrating polymer networks (semi-IPN), based on polyethylene glycol-co-fumarate (PEGF) and chitosan (Ch) blends. Hydrogel films were prepared by free radical cross-linking of PEGF, an unsaturated aliphatic polyester, in the presence of N-vinyl pyrrolidone (NVP), camphorquinone (CQ), and N,N-dimethylp-toluidine (DMPT) as a cross-linking, photoinitiating, and accelerating agent, respectively. The effect of NVP concentration on physicochemical and biological properties of semi-IPN film properties was evaluated. The sol fraction, water vapor transmission rate, and swelling degree of the hydrogel films were also investigated. Antibacterial activity against S. aureus was observed for the photocured blend hydrogels of Ch/PEGF with no toxicity to L929 cells according to the cell viability assays. Blend hydrogel films showing 600 ± 88% of equilibrium swelling degree in water and the lowest sol fraction (3.14 ± 1.22%) were obtained at 20 wt% of NVP content whilst preserving their own cytocompatibility and antibacterial activity. Therefore, this formulation was considered as an optimal semi-IPN blend hydrogel film composition with potential application for wound dressing.

In-situ photocrosslinkable nanohybrid elastomer based on polybutadiene/polyhedral oligomeric silsesquioxane

“…The CQ/amine photoinitiator/accelerator system is widely used for generating free radicals for photocuring of biomedical restoration or bioinjectable materials like dental materials [18][19][20]22,27]. Using this photoinitiation system, the unsaturated macromers were crosslinked and converted to the three dimensional networks with a free radical polymerization, which in CQ undergoes a so-called hydrogen abstraction type photoinitiation mechanism.…”

Polyethylene glycol/polyhedral oligomeric silsesquioxane as an in situ photocrosslinkable polymeric nanohybrid

“…CQ (photo‐initiator)/DMAEMA (accelerator) is extensively applied in tissue engineering as a photocrosslinking system to transform viscose liquid or putty‐like bioinjectable materials to three‐dimensional strong networks with a free radical polymerization mechanism. In this mechanism, which is usually used for some unsaturated macromers and reagents including dental materials, bone cement etc., CQ (sensitizer) generates a lot of high reactive amine‐derived free radicals in the presence of DMAEMA (a hydrogen‐donating agent) and blue‐cyan light irradiation . These photo‐generated radicals can attack and attach to the unsaturated C=C bonds of NVP and acrylate groups of POSSA and PEGDA, and subsequently initiate free radical polymerization to cure the mixture and create three‐dimensional nanohybrid networks.…”

Polyvinyl alcohol/soy protein isolate nanofibrous patch for wound-healing applications

“…A minimum adherence to the wound bed which provides an easy removal of the wound dress, so it would not cause a secondary trauma to the regenerated skin. Furthermore, a suitable microenvironment is necessary that a wound dressing should provide for wound healing (Saeed et al 2017; Doulabi et al 2015). Depending on the injury location and the type of the exudates, the mechanical and physiochemical properties of the wound dressing should suit the condition with adjustments (Moghadas et al 2016).…”

“…Depending on the injury location and the type of the exudates, the mechanical and physiochemical properties of the wound dressing should suit the condition with adjustments (Moghadas et al 2016). In this aspect, blend polymers are more beneficial in providing more previously mentioned requirements in comparison with a single polymer, since their properties are improved (Doulabi et al 2015).…”