Potential Antiradiation Agents. II. Selenium Analogs of 2-Aminoethylisothiouronium Hydrobromide and Related Compounds<sup>1-3</sup>

“…Many laboratory methods for the introduction of selenium into organic molecules are based upon conversion of the element into a nucleophilic species which is then capable of displacing a suitable active leaving group. This can be accomplished through the intermediate formation of a variety of inorganic selenium compounds such as hydrogen selenide, potassium selenocynate,4-6 potassium selenosulfate,7,8 or of compounds carrying a protective organic group such as benzyl selenol9 or selenourea, 10 In all these cases a separate preparative step is frequently required to remove the protecting group. To eliminate this extra effort, a number of procedures have been devised which lead directly from elemental selenium to alkylselenols or to the closely related diselenides.…”

mentioning

confidence: 99%

Methods in selenium chemistry. II. Bis(methoxymagnesium) diselenide, a novel reagent for the introduction of selenium into organic molecules

Guenther¹

1967

J. Org. Chem.

View full text Add to dashboard Cite

Radiosensitizers and Radioprotective Agents

Bump¹,

Hoffman²,

Foye

2003

Burger's Medicinal Chemistry and Drug Discovery

View full text Add to dashboard Cite

Various approaches have been developed for diminishing the effects of radiation on normal tissues or enhancing tumor cell killing by ionizing radiation. An important potential use for these agents is to modify the outcome of radiation therapy. Potential radioprotectors or radiosensitizers are organized in this review according to mechanism of action. Most of the agents studied are believed to act by reacting with DNA radicals that are produced within milliseconds of exposure to ionizing radiation. According to this mechanism, protectors restore a single electron to electron‐deficient radicals, preventing degradation of the structure of DNA, whereas sensitizers, such as molecular oxygen or nitroimidazoles, form adducts with these radicals, resulting in damage fixation. WR2721 (Ethyol) is the best‐characterized chemical radioprotector. Preferential activation of WR2721 in certain normal tissues by removal of a phosphate group provides a rationale for selective protection of these tissues. Cytokines and biological modifiers represent an important emerging class of radioprotectors that may be particularly useful in modifying bone marrow injury. Nitroimidazoles have been the most widely studied chemical radiosensitizers. Although clinical results with nitroimidazoles have not been impressive, the potential for this approach has not been fully explored, given that the doses that can be administered have been limited by drug toxicity and supplemental strategies, such as concurrent depletion of endogenous protectors, have not been explored in the clinic. Modifiers of tumor oxygenation represent an important class of radiosensitizers that are currently generating considerable clinical interest. RSR13, a modifier of the oxygen affinity of hemoglobin, is highlighted as an example of the process of drug development for this type of agent.

show abstract

Potential Antiradiation Agents. II. Selenium Analogs of 2-Aminoethylisothiouronium Hydrobromide and Related Compounds^1-3

Cited by 34 publications

References 2 publications

Synthesis of asymmetric [⁷⁵Se]selenoethers via carbodiimides

Synthesis of asymmetric [⁷⁵Se]selenoethers via carbodiimides

Methods in selenium chemistry. II. Bis(methoxymagnesium) diselenide, a novel reagent for the introduction of selenium into organic molecules

Radiosensitizers and Radioprotective Agents

Contact Info

Product

Resources

About

Potential Antiradiation Agents. II. Selenium Analogs of 2-Aminoethylisothiouronium Hydrobromide and Related Compounds1-3

Cited by 34 publications

References 2 publications

Synthesis of asymmetric [75Se]selenoethers via carbodiimides

Synthesis of asymmetric [75Se]selenoethers via carbodiimides

Methods in selenium chemistry. II. Bis(methoxymagnesium) diselenide, a novel reagent for the introduction of selenium into organic molecules

Radiosensitizers and Radioprotective Agents

Contact Info

Product

Resources

About

Potential Antiradiation Agents. II. Selenium Analogs of 2-Aminoethylisothiouronium Hydrobromide and Related Compounds^1-3

Synthesis of asymmetric [⁷⁵Se]selenoethers via carbodiimides

Synthesis of asymmetric [⁷⁵Se]selenoethers via carbodiimides