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2022
DOI: 10.1080/14786419.2022.2101052
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Potential antiplatelet aggregation metabolites from the discarded sorghum (Sorghum bicolor L.) root

Abstract: Metabolites of the fungus Cunninghamella echinulata NRRL 1382 were investigated under the effect of fusidic acid (1) feeding. In addition to ergosterol (2) which is a fungal sterol, two novel adipate esters (3, 4) were isolated, and their structures fully investigated using various spectroscopic analyses including 1D, 2D NMR and HRESIMS. In silico biological target prediction and molecular docking investigation revealed a potential agonist/antagonist activity for compound 3 by binding to µ opioid receptor and … Show more

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“…Due to their significant interaction with starch and particularly amylose, polymeric tannins are key in producing resistant starch. The tannin oligomers present human health benefits through their immunomodulatory, antiradical, vasodilatory, cardioprotective, antithrombotic, and anti-UV actions [ 47 , 48 , 49 ]. Others potential health benefits are risk reduction for obesity, dyslipidemia, hypertension, and promoting urination and blood circulation [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…Due to their significant interaction with starch and particularly amylose, polymeric tannins are key in producing resistant starch. The tannin oligomers present human health benefits through their immunomodulatory, antiradical, vasodilatory, cardioprotective, antithrombotic, and anti-UV actions [ 47 , 48 , 49 ]. Others potential health benefits are risk reduction for obesity, dyslipidemia, hypertension, and promoting urination and blood circulation [ 50 ].…”
Section: Discussionmentioning
confidence: 99%