Potential Anticancer Properties and Mechanisms of Action of Withanolides

Samadi, Abbas

doi:10.1016/bs.enz.2015.05.002

Cited by 25 publications

(22 citation statements)

References 123 publications

(149 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the same study, incubation of WFA with strong reducing agents like N-acetyl cysteine or DTT resulted into loss of the pro-apoptotic activity of WFA [53]. On the other hand, loss of unsaturation in the A-ring have been reported to cause loss of anti-inflammatory and antiangiogenic effects of WFA [43,54].…”

Section: A B Cmentioning

confidence: 86%

“…These biological activities include anti-inflammatory, anticancer, antiangiogenic, cardioprotective, immunomodulatory, hepatoprotective, anticonvulsant and anabolic effects [43,51]. However, in the past decade or so, WFA has attracted significant attention and testing mainly for its anticancer activity [44].…”

Section: A B Cmentioning

confidence: 99%

“…At that time, the basic extraction of WFA from the dried W. somnifera material was accomplished using methanol followed by purification with C-18 and Sefadex columns [45]. Later, WFA was also extracted from other plants including Withania aristata, Dunalia spinose and Vassobia breviflora [43,46]. Because of the multiple reports on the anticancer activity of WFA, significant efforts are now being directed towards the chemical synthesis and modification of WFA [47].…”

Section: E F a B Cmentioning

confidence: 99%

“…To date, more than 300 different naturally occurring withanolides with diverse chemical and biological activities have been isolated and characterized from the Solanaceae plant species [43]. Of all these, WFA [4β, 27-dihydroxy-1-oxo-5β, 6β-epoxywitha-2, 24-dienolide], was the first member to be discovered and is currently the most extensively studied and characterized [42,[44][45][46].…”

Section: E F a B Cmentioning

confidence: 99%

See 3 more Smart Citations

Withaferin a synergistically enhances the effects of paclitaxel against lung cancer.

Kyakulaga¹

View full text Add to dashboard Cite

Section: A B Cmentioning

confidence: 86%

Section: A B Cmentioning

confidence: 99%

Section: E F a B Cmentioning

confidence: 99%

Section: E F a B Cmentioning

confidence: 99%

See 2 more Smart Citations

Withaferin a synergistically enhances the effects of paclitaxel against lung cancer.

Kyakulaga¹

View full text Add to dashboard Cite

“…Together, the combination of these scores allows the NSCLC cases to be grouped into the seven stages; IA, IB, IIA, IIB, IIIA, IIIB, and V. For prognostic purposes, the NSCLC cases assigned to stages IA, IB, IIA, and IIB are generally considered to be in the early-stages of the disease. For these early-stages of NSCLC, the primary tumors are associated with no evidence of local or distant metastases [20,21]. On the other hand, NSCLC cases that display tumor descriptors which fall into the stages III-V display evidence of metastatic nodules in the regional lymph nodes and/or distant organs.…”

Section: The Nsclc Staging Systemmentioning

confidence: 99%

Therapeutic potential of withaferin A against non-small cell lung cancer.

Kyakulaga¹

View full text Add to dashboard Cite

The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

Khan

Shal

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Cancer is the leading cause of mortality and morbidity worldwide, and its cases are rapidly increasing every year. Several factors contribute to the development of tumorigenesis. including radiation, dietary lifestyle, smoking, environmental, and genetic factors. The cell cycle is regulated by a variety of molecular signaling proteins. However, when the proteins involved in the cell cycle regulation are altered, cellular growth and proliferation are significantly affected. Natural products provide an important source of new drug development for a variety of ailments. including cancer. Phytosterols (PSs) are an important class of natural compounds reported for numerous pharmacological activities, including cancer. Various PSs, such as ergosterol, stigmasterol, sitosterol, withaferin A, etc., have been reported for their anti‐cancer activities against a variety of cancer by modulating the tumor microenvironment via molecular signaling pathways discussed within the article. These signaling pathways are associated with the production of pro‐inflammatory mediators, growth factors, chemokines, and pro‐apoptotic and anti‐apoptotic genes. These mediators and their upstream signaling are very active within the variety of tumors and by modulating these signalings, thus PS exhibits promising anti‐cancer activities. However, further high‐quality studies are needed to firmly establish the clinical efficacy as well the safety of the phytosterols.

show abstract

Potential Anticancer Properties and Mechanisms of Action of Withanolides

Cited by 25 publications

References 123 publications

Withaferin a synergistically enhances the effects of paclitaxel against lung cancer.

Withaferin a synergistically enhances the effects of paclitaxel against lung cancer.

Therapeutic potential of withaferin A against non-small cell lung cancer.

The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

Contact Info

Product

Resources

About