Potential anticancer and antioxidant lauric acid-based hydrazone synthesis and computational study toward the electronic properties

Assiri, Mohammed A.; Ali, Akbar; Ibrahim, Muhammad; Khan, Muhammad Usman; Kettab, Ahmed; Akash, Muhammad Sajid Hamid; Abbas, Muhammad Akhtar; Javed, Athar; Suleman, Muhammad; Khalid, Muhammad; Hussain, Ishtiaq

doi:10.1039/d3ra02433d

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…This has led to the evaluation of diverse small molecule templates as potential cancer therapies. 3,4 With these advances and findings, a number of pharmaceuticals are now often used to treat cancer. Although these medications have demonstrably extended patient lifespans, treatment success is not at the expected level.…”

Section: Introductionmentioning

confidence: 99%

Novel carbazolyl–thiazolyl–chromone and carbazolyl–thiazolyl–pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies

Hassanin,

Ali,

Assiri

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Novel carbazolyl–thiazolyl–chromone and carbazolyl–thiazolyl–pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies

Hassanin,

Ali,

Assiri

et al. 2024

RSC Adv.

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“…Lauric oils are characterized by their significant lauric acid content (12:0 or dodecanoic acid) as the predominant fatty acid. Historically, coconut oil has been the primary and most well-known source of lauric oil, obtained from the copra, the inner meat of coconut 17 – 19 . Verma et al found the result of anticancer activity of various concentrations of Virgin Coconut Oil (VCO), Fractionated Coconut Oil (FCO) and Processed Coconut Oil (PCO) to be different when treated with oral cancer (KB cell line) cells.…”

Section: Introductionmentioning

confidence: 99%

Anticancer potential of thiocolchicoside and lauric acid loaded chitosan nanogel against oral cancer cell lines: a comprehensive study

Mustafa,

Indiran,

Ramalingam

et al. 2024

Sci Rep

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The present study explored the anticancer activity of a Chitosan-based nanogel incorporating thiocolchicoside and lauric acid (CTL) against oral cancer cell lines (KB-1). Cell viability, AO/EtBr dual staining and Cell cycle analysis were done to evaluate the impact of CTL nanogel on oral cancer cells. Real-time PCR was performed to analyze proapoptotic and antiapoptotic gene expression in CTL-treated KB-1 cells. Further, molecular docking analysis was conducted to explore the interaction of our key ingredient, thiocolchicoside and its binding affinities. The CTL nanogel demonstrated potent anticancer activity by inhibiting oral cancer cell proliferation and inducing cell cycle arrest in cancer cells. Gene expression analysis indicated alterations in Bax and Bcl-2 genes; CTL nanogel treatment increased Bax mRNA expression and inhibited the Bcl-2 mRNA expression, which showed potential mechanisms of the CTL nanogel's anticancer action. It was found that thiocolchicoside can stabilize the protein's function or restore it as a tumour suppressor. The CTL nanogel exhibited excellent cytotoxicity and potent anticancer effects, making it a potential candidate for non-toxic chemotherapy in cancer nanomedicine. Furthermore, the nanogel's ability to modulate proapoptotic gene expression highlights its potential for targeted cancer therapy. This research contributes to the growing interest in Chitosan-based nanogels and their potential applications in cancer treatment.

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Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies

Tapera,

Kekeçmuhammed,

Sarıpınar

et al. 2023

Journal of Molecular Liquids

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Potential anticancer and antioxidant lauric acid-based hydrazone synthesis and computational study toward the electronic properties

Abstract: The modification of natural products is one of the key areas of synthetic organic chemistry for obtaining valuable chemical building blocks that have medicinal significance.

Cited by 3 publications

References 37 publications

Novel carbazolyl–thiazolyl–chromone and carbazolyl–thiazolyl–pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies

Novel carbazolyl–thiazolyl–chromone and carbazolyl–thiazolyl–pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies

Anticancer potential of thiocolchicoside and lauric acid loaded chitosan nanogel against oral cancer cell lines: a comprehensive study

Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies

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