Potential antibiotic-producing fungal strains isolated from pharmaceutical waste sludge

Omeike, Sunday Osaizua; Kareem, Sarafadeen Olateju; Lasisi, A. A.

doi:10.1186/s43088-019-0026-8

Cited by 8 publications

(4 citation statements)

References 27 publications

(23 reference statements)

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“…One of the important advantages of antibacterial nanomedicines is their potential to substitute for antibiotics. However, the A. welwitschiae strain is a promising antibiotic-producing strain ( Omeike et al, 2019 ; Maliehe et al, 2022 ). This means that the antibacterial activity of Bio-TeNPs produced by A. welwitschiae might be due to its antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Green synthesis of biogenetic Te(0) nanoparticles by high tellurite tolerance fungus Mortierella sp. AB1 with antibacterial activity

et al. 2022

Front. Microbiol.

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Tellurite [Te(IV)] is a high-toxicity metalloid. In this study, a fungus with high Te(IV) resistance was isolated. Strain AB1 could efficiently reduce highly toxic Te(IV) to less toxic Te(0). The reduced products formed rod-shaped biogenetic Te(0) nanoparticles (Bio-TeNPs) intracellularly. Further TEM-element mapping, FTIR, and XPS analysis showed that the extracted Bio-TeNPs ranged from 100 to 500 nm and consisted of Te(0), proteins, lipids, aromatic compounds, and carbohydrates. Moreover, Bio-TeNPs exhibited excellent antibacterial ability against Shigella dysenteriae, Escherichia coli, Enterobacter sakazakii, and Salmonella typhimurium according to inhibition zone tests. Further growth and live/dead staining experiments showed that E. coli and S. typhimurium were significantly inhibited by Bio-TeNPs, and cells were broken or shriveled after treatment with Bio-TeNPs based on SEM observation. Additionally, the antioxidant and cytotoxicity tests showed that the Bio-TeNPs exhibited excellent antioxidant capacity with no cytotoxicity. All these results suggested that strain AB1 showed great potential in bioremediation and Bio-TeNPs were excellent antibacterial nanomaterials with no cytotoxicity.

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Section: Discussionmentioning

confidence: 99%

Green synthesis of biogenetic Te(0) nanoparticles by high tellurite tolerance fungus Mortierella sp. AB1 with antibacterial activity

et al. 2022

Front. Microbiol.

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“…The F. oxysporum in rice washing water media reduced leaf fresh weight by 30% while C. lunata in tofu liquid waste media reduced leaf fresh weight by 35% each compared to control. Organic liquid waste supports the multiplication of weed pathogenic fungi (Neher et al, 2013;Omeike et al, 2019), thereby increasing the number of conidia per mL, pathosystem components, and reducing weed growth. The fresh weight of weeds was lower due to the attack of weed pathogenic fungi.…”

Section: Effect Of the Treatments On Growth Componentsmentioning

confidence: 99%

Propagation and shelf-life of weed pathogenic fungi in alternative media and their effectiveness in billygoat (Ageratum conyzoides L)

Soesanto,

Sastyawan,

Manan

et al. 2023

E-Journal Menara Perkebunan

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Control of billygoat (Ageratum conyzoides L) currently uses herbicides, on the other hand, control using pathogenic fungi is environmentally friendly, but for mass propagation and storage, alternative media are needed. The aim of the study was to determine the best type of alternative media for fungal growth and shelf life, as well as its effectiveness against billygoat. The treatment tested involves a combination of two factors: the type of pathogenic fungi (Curvularia lunata or Fusarium oxysporum) and the type of medium (rice washing water or tofu liquid waste). A completely randomized design was used for the in vitro test, while in planta test used a randomized block design with each experimental unit repeated five times. The observed variables were conidia density, number of colonies, incubation period, disease symptoms, disease intensity, and area under the disease progress curve (AUDPC), as well as weed height, number of leaves, fresh and dry shoot, and root weights. The results showed that the conidia density of F. oxysporum was 57% better in rice washing water than in tofu wastewater. The best shelf life for the fungus was four weeks. The use of rice washing water for F. oxysporum and C. lunata effectively delayed the incubation period by 77 and 71% respectively, suppressed disease intensity by 90 and 88%, and AUDPC by 94 and 93% compared to the control. The F. oxysporum grown on rice washing water media was able to reduce the number of leaves, fresh and dry weight of billygoat by 25, 30, and 20% compared to the control, respectively.

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“…Microscopic features were observed using an electron microscope equipped with a 40X objective lens. To do this, a small portion of the fungal growth area was mounted on a clean, grease-free slide with a drop of lactophenol cotton blue, covered with a cover slip, and examined as per the standard procedures [12][13]. The characterization and identification of the isolates were conducted with reference to established literature sources [14][15][16][17][18][19][20][21][22].…”

Section: Microscopic Identificationmentioning

confidence: 99%

Molecular Identification of Potent Antimicrobial Marine Fungi from Manginapudi Beach (Machilipatnam, India)

Shabana,

Satya

2023

ijmst

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The primary objective of this study is to isolate and characterize marine fungi exhibiting antimicrobial properties, collected from Manginapudi Beach located in Machilipatnam along the Indian coast of the Bay of Bengal. The present investigation involved the isolation of marine fungi from seawater samples, with a 0.1 ml sample residue being introduced onto various fungal growth media. These isolated fungi were identified using the Internal Transcribed Spacer (ITS) region. Subsequently, phylogenetic analysis was conducted using MEGA-X to elucidate the relationships between the isolates and closely related species available in the NCBI-GenBank database. The crude extracts of these isolated marine fungi were then prepared and evaluated for their antimicrobial efficacy against various test organisms. Four fungal isolates, namely SS7, SS9, SS10, and SS11, exhibited a 100% similarity match and were conclusively identified as Fusarium incarnatum (SS7), Hamigera insecticola (SS9), Talaromyces tratensis (SS10), and Neurospora crassa (SS11). Notably, this study reports the first-time presence of Acremonium persicinum, Fusarium equiseti, F. incarnatum, F. pernambucanum, Hamigera avellanea, H. insecticola, and Talaromyces tratensis in the Manginapudi Beach region. Among the findings, the ethyl acetate extract of T. tratensis (SS10) demonstrated a significant zone of inhibition, measuring 22.1±0.28 mm against Candida albicans. Similarly, Acremonium persicinum (SS6) exhibited the highest zone of inhibition (29.8±0.26 mm) against Escherichia coli. The outcomes of this study strongly indicate that Manginapudi Beach serves as a valuable repository of marine fungi displaying significant antimicrobial potential. To fully substantiate and utilize this potential, additional investigation is required to isolate and thoroughly characterize the active components within these crude extracts. This in-depth analysis will offer conclusive evidence regarding the bioactive properties of marine fungi.

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Potential antibiotic-producing fungal strains isolated from pharmaceutical waste sludge

Cited by 8 publications

References 27 publications

Green synthesis of biogenetic Te(0) nanoparticles by high tellurite tolerance fungus Mortierella sp. AB1 with antibacterial activity

Green synthesis of biogenetic Te(0) nanoparticles by high tellurite tolerance fungus Mortierella sp. AB1 with antibacterial activity

Propagation and shelf-life of weed pathogenic fungi in alternative media and their effectiveness in billygoat (Ageratum conyzoides L)

Molecular Identification of Potent Antimicrobial Marine Fungi from Manginapudi Beach (Machilipatnam, India)

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