Potential and Prospects of Shikonin Production Enhancement in Medicinal Plants

Pal, Minakshi; Kumar, Vinod; Yadav, Rakesh; Gulati, Deepika

doi:10.1007/s40011-017-0931-3

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…For instance, the presence of phytohormones such as methyl jasmonate (MeJA), ethylene, auxins and fungal elicitors are known to increase the production of A/Sd in planta . Whereas light, ammonium, or benzoic acid inhibit their production ( Brigham et al, 1999 ; Pal et al, 2019 ). Recent studies were performed to elucidate the shikonin production pathway and its regulation in planta .…”

Section: Introductionmentioning

confidence: 99%

Root-associated bacteria modulate the specialised metabolome of Lithospermum officinale L.

et al. 2022

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Bacteria influence plant growth and development and therefore are attractive resources for applications in agriculture. However, little is known about the impact of these microorganisms on secondary metabolite (SM) production by medicinal plants. Here we assessed, for the first time, the effects of bacteria on the modulation of SM production in the medicinal plant Lithospermum officinale (Boraginaceae family) with a focus on the naphthoquinones alkannin/shikonin and their derivatives (A/Sd). The study was conducted in an in vitro cultivation system developed for that purpose, as well as in a greenhouse. Targeted and non-targeted metabolomics were performed, and expression of the gene PGT encoding for a key enzyme in the A/S biosynthesis pathway was evaluated with qPCR. Three strains, Chitinophaga sp. R-73072, Xanthomonas sp. R-73098 and Pseudomonas sp. R-71838 induced a significant increase of A/Sd in L. officinale in both systems, demonstrating the strength of our approach for screening A/Sd-inducing bacteria. The bacterial treatments altered other plant metabolites derived from the shikimate pathway as well. Our results demonstrate that bacteria influence the biosynthesis of A/Sd and interact with different metabolic pathways. This work highlights the potential of bacteria to increase the production of SM in medicinal plants and reveals new patterns in the metabolome regulation of L. officinale.

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Section: Introductionmentioning

confidence: 99%

Root-associated bacteria modulate the specialised metabolome of Lithospermum officinale L.

et al. 2022

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“…A/S and its derivatives are used for dyeing in areas such as textile, food, cosmetics (Pal et al 2017). The compounds have also various biological activities such as a strong wound healing (Papageorgiou et al 2008) antibacterial and antifungal properties (Damianakos et al 2012), antiinflammatory (Mahmoudi et al 2012), antioxidant (Wang et al 2010), as well as antiallergic, antineoplastic, antipyretic and antihydropic activities (Su et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Callus induction and regeneration of Alkanna orientalis var. Orientalis and A. sieheana

Yaman

Uranbey

Ahmed³

et al. 2019

Bangladesh J. Bot.

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Callus induction and proliferation of Alkanna orientalis var. orientalis and Alkanna sieheana containing valuable alkannin/shikonin (A/S) derivates were investigated using leaf base and stem segment explants. Stem segments and cotyledonary leaf base of both species were cultured on Murashige and Skoog medium fortified with different concentrations of BAP, Kn, NAA, IAA and IBA for callus induction and shoot regeneration. High frequency reproducible, prolific and compact calli formation was obtained from the stem segments of both species in all media tested. The frequency variations of callus induction and shoot regeneration were discussed in terms of different species, plant growth regulators and explant resources. A. orientalis and A. sieheana may be considered to be alternative plants for the A/S production in vitro.

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Antiallergic Metabolite Production from Plants via Biotechnological Approaches

Tilkat,

Sökmen

2024

Biotechnology of Medicinal Plants With Antiallergy Properties

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Potential and Prospects of Shikonin Production Enhancement in Medicinal Plants

Cited by 5 publications

References 23 publications

Root-associated bacteria modulate the specialised metabolome of Lithospermum officinale L.

Root-associated bacteria modulate the specialised metabolome of Lithospermum officinale L.

Callus induction and regeneration of Alkanna orientalis var. Orientalis and A. sieheana

Antiallergic Metabolite Production from Plants via Biotechnological Approaches

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