Potential advantages of Chinese medicine Taohong Siwu Decoction (桃红四物汤) combined with tissue-plasminogen activator for alleviating middle cerebral artery occlusion-induced embolic stroke in rats

Yen, Ting Lin; Ong, Eng Thiam; Lin, Kuan Hung; Chang, Chao; Jayakumar, Thanasekaran; Lin, Song; Fong, Tsorng Harn; Sheu, Joen Rong

doi:10.1007/s11655-014-1847-x

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…A wide range of benefits of THSWD have been identified since its introduction, including stimulation of blood circulation, neuroprotection, and facilitation of angiogenesis (17)(18)(19). A combination of a recombinant tissue-type plasminogen activator and THSWD resulted in a decreased infarct size, it stimulated cerebral blood circulation, and it enhanced neuron function in patients who had suffered a cerebral embolic stroke (20). THSWD has been used to treat rabbits in a model of SANFH, resulting in reduced blood viscosity, increased regeneration of local microvessels, improved local blood supply, and facilitation of the recovery of the necrotic femoral head (21,22).…”

Section: Introductionmentioning

confidence: 99%

Tao-Hong-Si-Wu Decoction ameliorates steroid-induced avascular necrosis of the femoral head by regulating the HIF-1α pathway and cell apoptosis

Yao

Wang

et al. 2016

BST

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Section: Introductionmentioning

confidence: 99%

Tao-Hong-Si-Wu Decoction ameliorates steroid-induced avascular necrosis of the femoral head by regulating the HIF-1α pathway and cell apoptosis

Yao

Wang

et al. 2016

BST

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“…In accordance with Yiqi Huoxue, the traditional Chinese medicines THSWD and BYD were reported to markedly improve heart function in patients with congestive heart failure in conjunction with conventional therapy (20,21). Experimental studies confirmed that THSWD can inhibit proliferation of myocardium interstitial collagenous fibers and expression of collagen protein after acute myocardial infarction (MI) in rats (22), decrease hepatic necroinflammatory disease and fibrosis in an animal model of chronic liver disease (23), and inhibit inflammatory responses by decreasing the expression of TNF-α in cerebral ischemia (24). Both Zhang et al and Du et al found that cardioprotection conferred by BYD was related to attenuation of oxidative stress and inflammatory cell infiltration in CHF post-MI induced by ligation of the left anterior descending (LAD) artery (25,26).…”

Section: Introductionmentioning

confidence: 93%

Bao Yuan decoction and Tao Hong Si Wu decoction improve lung structural remodeling in a rat model of myocardial infarction: Possible involvement of suppression of inflammation and fibrosis and regulation of the TGF-β1/Smad3 and NF-κB pathways

Gao

Han

et al. 2018

BST

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Chronic heart failure (CHF) leads to pulmonary structural remodeling, which may be a key factor for poor clinical outcomes in patients with end-stage heart failure, and few effective therapeutic options are presently available. The aim of the current study was to explore the mechanism of action and pulmonary-protective effects of treatment with Bao Yuan decoction combined with Tao Hong Si Wu decoction (BYTH) on lung structural remodeling in rats with ischemic heart failure. In a model of myocardial infarction (MI) induced by ligation of the left anterior descending (LAD) artery, rats were treated with BYTH. Heart function and morphometry were measured followed by echocardiography, histological staining, and immunohistochemical analysis of lung sections. The levels of transforming growth factor-β1 (TGF-β1), type I collagen, phosphorylated-Smad3 (p-Smad3), tumor necrosis factor-α (TNF-α), toll-like receptor 4 (TLR4), active nuclear factor κB (NF-κB) and alpha smooth muscle actin (α-SMA) were detected using Western blotting. Lung weight increased after an infarct with no evidence of pulmonary edema and returned to normal as a result of BYTH. In addition, BYTH treatment reduced levels of type I collagen, TGF-β1, and α-SMA expression and decreased the phosphorylation of Smad3 in the lungs of rats after MI. BYTH treatment also reduced the elevated levels of lung inflammatory mediators such as TNF-α, TLR4, and NF-κB. Results suggested that BYTH could effectively improve lung structural remodeling after MI because of its anti-inflammatory and anti-fibrotic action, which may be mediated by suppression of the TGF-β1/Smad3 and NF-κB signaling pathways.

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“…Similarly, ShenGui SanSheng san could also improve the efficiency of citric acid cycle to improve the brain energy deficit after ischemia (Luo et al, 2019). Interestingly, as a cell-sensing oxygen sensor, most studies have also reported evidence of other TCM prescriptions regulating HIF-1a to inhibit apoptosis and inflammation in treatment of stroke, such as XueFu ZhuYu decoction (Lee et al, 2011) and TaoHong SiWu decoction (Yen et al, 2014). Members of the Bcl-2 family are also potential targets for prescription inhibition of apoptosis to improve ischemic brain injury.…”

Section: Prescription and Molecular Mechanisms In Regulating Mptp Opementioning

confidence: 99%

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

Sun

et al. 2020

Front. Pharmacol.

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Mammalian mitochondrial permeability transition pore (MPTP), across the inner and outer membranes of mitochondria, is a nonspecific channel for signal transduction or material transfer between mitochondrial matrix and cytoplasm such as maintenance of Ca 2+ homeostasis, regulation of oxidative stress signals, and protein translocation evoked by some of stimuli. Continuous MPTP opening has been proved to stimulate neuronal apoptosis in ischemic stroke. Meanwhile, inhibition of MPTP overopening-induced apoptosis has shown excellent efficacy in the treatment of ischemic stroke. Among of which, the potential molecular mechanisms of drug therapy for stroke has also been gradually revealed by researchers. The characteristics of multi-components or multitargets for ethnic drugs also provide the possibility to treat stroke from the perspective of mitochondrial MPTP. The advantages mentioned above make it necessary for us to explore and clarify the new perspective of ethnic medicine in treating stroke and to determine the specific molecular mechanisms through advanced technologies as much as possible. In this review, we attempt to uncover the relationship between abnormal MPTP opening and neuronal apoptosis in ischemic stroke. We further summarized currently authorized drugs, ethnic medicine prescriptions, herbs, and identified monomer compounds for inhibition of MPTP overopening-induced ischemic neuron apoptosis. Finally, we strive to provide a new perspective and enlightenment for ethnic medicine in the prevention and treatment of stroke by inhibition of MPTP overopeninginduced neuronal apoptosis.

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Potential advantages of Chinese medicine Taohong Siwu Decoction (桃红四物汤) combined with tissue-plasminogen activator for alleviating middle cerebral artery occlusion-induced embolic stroke in rats

Cited by 11 publications

References 31 publications

Tao-Hong-Si-Wu Decoction ameliorates steroid-induced avascular necrosis of the femoral head by regulating the HIF-1α pathway and cell apoptosis

Tao-Hong-Si-Wu Decoction ameliorates steroid-induced avascular necrosis of the femoral head by regulating the HIF-1α pathway and cell apoptosis

Bao Yuan decoction and Tao Hong Si Wu decoction improve lung structural remodeling in a rat model of myocardial infarction: Possible involvement of suppression of inflammation and fibrosis and regulation of the TGF-β1/Smad3 and NF-κB pathways

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

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