Potential Activity of Carrageenan to Enhance Antibacterial Host-Defense Systems in Mice

Tateda, Kazuhiro; Irifune, Kenji; Shimoguchi, Kazunori; Tomono, Kazunori; Matsumoto, Tetsuya; Kaku, Mitsuo; Yamaguchi, Keizo; Hirakata, Yoichi

doi:10.1007/bf02347730

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…We also observed that intraperitoneal administration of carrageenan 24 h before induction of pleurisy enhanced the chemotactic response in the pleural cavity of mice. 12 These results and the present data suggest that carrageenan may modulate complement-mediated inflammatory and immunological responses producing an initial suppression followed by enhancement of C3.…”

Section: Resultssupporting

confidence: 75%

“…Recently, several investigators have reported that carrageenan may potentially modulate the production of inflammatory cytokines such as interleukin-1 (IL-1), IL-6 and tumour necrosis factor (TNF). [11][12][13] Since these cytokines are known to play a critical role in inducing acute phase proteins including complement, 14 we speculate that carrageenan may influence the host-complement system not only through direct inactivation of complement, but also production of these cytokines.…”

Section: Introductionmentioning

confidence: 99%

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Acute induction of interleukin‐6 and biphasic changes of serum complement C3 by carrageenan in mice

Tateda¹,

Matsumoto²,

Yamaguchi³

1998

Mediators of Inflammation

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Carrageenan has been widely used as an irritant to evoke inflammation in animals or to selectively deplete macrophages in vivo. Although precise understanding of carrageenan activity is a prerequisite for the experimental use of this polysaccharide, the effects of this agent on host-biological systems are still poorly understood. We investigated the effect of carrageenan on serum concentrations of complement C3 and interleukin (IL)-6, a potent complement-inducing factor. Intraperitoneal administration of carrageenan (4 mg) in mice resulted in an initial fall in serum C3 (70% of control, P < 0.05) between 3 and 6 h, but was followed by a significant rise (180% of the control, P < 0.05) at 24h. Prior to the rise in complement C3, a sharp peak of serum IL-6 was observed at 6h after carrageenan treatment. These results indicate potential of carrageenan to enhance host complement systems, which may be associated with, at least in part, an acute induction of IL-6.

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Section: Resultssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Acute induction of interleukin‐6 and biphasic changes of serum complement C3 by carrageenan in mice

Tateda¹,

Matsumoto²,

Yamaguchi³

1998

Mediators of Inflammation

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“…The administration of kappa-carrageenan has been reported to increase the phagocytic activity of carp Cyprinus carpio and its resistance against Edwardsiella tarda and Aeromonas hydrophila administered via intraperitoneal injection (Fujiki et al 1997). The influence of carrageenan on the lipopolysaccharide (LPS) in the pleural cavity and interleukin-1 production by pleural macrophages was studied by Tateda et al (1995). Their results demonstrated that intraperitoneal administration of carrageenan protected mice from lethal challenge with Klebsiella pneumoniae DT-S.…”

Section: Introductionmentioning

confidence: 95%

Influence of red algal polysaccharides on biological activities and supramolecular structure of bacterial lipopolysaccharide

et al. 2015

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The present work reveals the effect of kappa-, lambda-and kappa/beta-carrageenans on the immune modulation and supramolecular structure of lipopolysaccharide (LPS). The kappa/beta carrageenan was able to increase the synthesis of anti-inflammatory interleukin-10 (IL-10) in vitro, and at low concentrations, their activity in the mixture with LPS was higher than that of LPS alone. Kappa-carrageenan significantly inhibited LPS-induced upregulation of reactive oxygen species (ROS). The activation of cells by kappa-carrageenan occurs through TLR4 receptor specific for LPS. Carrageenans reduced (kappa-) or completely inhibited (lambda-) collageninduced platelet aggregation and decreased their aggregation activity caused by cooperative effect of LPS and collagen. The transformation of ultrastructure of LPS by action of kappa-and kappa/beta-carrageenans is observed. Moreover, carrageenans changed both the sizes and ζ-potentials of the LPS.

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“…As phagocytic cells, they can eliminate certain organisms. However, when the number of organisms increases beyond the ability of the macrophages to handle them or when the organisms are particularly virulent, the macrophage becomes a mediator of an in¯ammatory response by producing cytokines that recruit neutrophils into the lung [9]. Various cytokines have been identi®ed that appear to play an important role in this regard, especially tumour necrosis factor-á (TNF-á) and interleukin-1 (IL-1)…”

Section: Introductionmentioning

confidence: 99%

Role of bacterial capsule in local and systemic inflammatory responses of mice during pulmonary infection with Klebsiella pneumoniae

Yoshida¹,

Matsumoto

Tateda

et al. 2000

Journal of Medical Microbiology

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The role of bacterial capsule in in¯ammatory responses in experimentally induced pneumonia caused by Klebsiella pneumoniae was evaluated by comparing the host immunological responses in mice infected with capsulate strain DT-S and non-capsulate mutant strain DT-X. Anaesthetised ICR mice were infected intranasally with inocula of strain DT-S or DT-X. Mice infected with strain DT-X survived signi®cantly longer than those inoculated with strain DT-S. Viable bacterial counts in lungs and blood increased rapidly in mice infected with strain DT-S, in contrast to the gradual decrease in their density in lungs and intermittent bacteraemia in mice infected with strain DT-X. The number of broncho-alveolar lavage (BAL) cells in mice infected with strain DT-X at 24 h after inoculation was signi®cantly higher than in those infected with strain DT-S. In the early stages of infection, the levels of tumour necrosis factor-á and interleukin-6 in BAL uid of mice infected with strain DT-X were signi®cantly higher than those of mice infected with strain DT-S. In contrast, in the late stage of infection, the levels of these cytokines in serum of mice infected with strain DT-S were signi®cantly higher than in mice infected with strain DT-X. These results suggest that K. pneumoniae capsule may suppress the host immunological responses, thus allowing the bacteria to grow, causing pneumonia, septicaemia and death.

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Potential Activity of Carrageenan to Enhance Antibacterial Host-Defense Systems in Mice

Cited by 7 publications

References 21 publications

Acute induction of interleukin‐6 and biphasic changes of serum complement C3 by carrageenan in mice

Acute induction of interleukin‐6 and biphasic changes of serum complement C3 by carrageenan in mice

Influence of red algal polysaccharides on biological activities and supramolecular structure of bacterial lipopolysaccharide

Role of bacterial capsule in local and systemic inflammatory responses of mice during pulmonary infection with Klebsiella pneumoniae

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