Potential Activity of Aqueous Extract of Culinary-Medicinal Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in Accelerating Wound Healing in Rats

Abstract

This study was conducted to evaluate the effects of topical application of aqueous extract of Hericium erinaceus fruiting bodies (HEFB) on the rate of wound healing enclosure and histology of the healed wound. Five groups of male Sprague-Dawley rats were experimentally wounded in the posterior neck area. A uniform wound area of 2.00 cm in diameter, using a circular stamp, was excised from the nape of the dorsal neck of all rats with the aid of a round seal. The animal groups were topically treated, respectively, with 0.2 mL each of sterilized distilled water (sdH2O); Intrasite gel; and 20, 30, and 40 mg/mL HEFB. Macroscopically, those rats whose wounds were dressed with HEFB and those in the Intrasite gel-treated group healed earlier than those treated with sdH2O. Histological analysis of healed wounds dressed with HEFB showed less scar width at wound enclosure and the healed wound contained fewer macrophages and more collagen with angiogenesis, compared to wounds dressed with sdH2O. In conclusion, wounds dressed with HEFB significantly enhanced the acceleration of wound healing enclosure in rats.

Migration and Proliferation Effects of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) and Thymoquinone (TQ) on In Vitro Wound Healing Models

“…Wound healing mechanism may be caused by high antioxidant activity of the plant compounds or extracts used for its treatment. Antioxidants play an important role in the course of wound healing by decreasing the healing time and manifesting the healed tissue [75][76][77]. A proper and precise balance between the oxidative and antioxidative systems is vital for cell proliferation [78].…”

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

“…Moreover, there was an increase in the microvascular permeability and lipid peroxidation of the cell membrane in the stomach epithelium. Therefore, it might be proposed that C. barometz extract mediates the protection of the gastric mucosa as a result of its scavenging mechanism 49. Furthermore, C. barometz extract demonstrated protection of the cell membrane via the activities of SOD and CAT elevations from reactive oxygen species (ROS) attack.…”

A novel oligosaccharide isolated fromHericium erinaceusand its protection against LPS‐induced Caco‐2 cells via the TLR4/NF‐κB pathway

“…Accumulating evidence have shown that water‐soluble oligosaccharides (Guihong et al, ), polysaccharides (Xiao‐yin, Duo‐Duo, Jun‐Yi, Shao‐Ping, & Ming‐Yong, ), and glycoproteins (Zhe et al, ) are the main active component of the HE, which response to the antioxidant and anti‐inflammatory functions. Importantly, it has received a great deal of attention for its pharmacological activity in the prevention and therapies of gastrointestinal diseases (Abdulla et al, ). Extensive clinical practice has shown that the Chinese traditional medicine HE, either applied alone or used as an assistant together with other chemical drugs, has preventive or therapeutic effects with rarely adverse reactions on digestive system diseases, such as chronic gastritis, dyspepsia, ulcerative colitis (UC), gastric, and duodenal ulceration, etc., (Xiao‐Yin et al, ).…”