Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates

Abstract

Aging is an irreversible physiological process in the human body, and the aging characteristics of the body that accompany this process also lead to many other chronic diseases, such as neurodegenerative diseases represented by Alzheimer's disease and Parkinson's disease, cardiovascular diseases, hypertension, obesity, cancer, and so on. The marine environment is highly biodiverse, the natural active products of these organisms constitute a vast treasure trove of marine drugs or drug candidates that play an essential role in disease prevention and treatment, and the active peptide products among them have received special attention because of their unique chemical properties. Therefore, the development of marine peptide compounds as anti-aging drugs is emerging as an important research area. This review highlights the currently available data on marine bioactive peptides with anti-aging potential from 2000 to 2022 by analyzing the prevalent aging mechanisms, critical aging metabolic pathways and well-established multi-omics aging characteristics, as well as grouping different bioactive and biological species lines of peptides from marine organisms and discussing their research modalities and functional characteristics. Active marine peptides is a promising topic to explore and to develop their potential as anti-aging drugs or drug candidates. We expect this review to be instructive for future marine drug development and to reveal new directions for future biopharmaceuticals.

Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging

“…The anti-aging industry is growing rapidly with the release of new supplements and nutraceuticals that promise youthful skin, better joint and bone health, and even stronger immune systems [29,31,32]. Among the most popular products is marine-derived collagen used for skin health and restoration.…”

Chemical diversity and therapeutic potentialities of seaweeds and marine sponges collected from the Red Sea: An update

“…In the same context, a diverse array of chemical compounds has been isolated or identified from different marine organisms such as alkaloids (Moriou et al, 2021;Tempone et al, 2021), anthraquinones (Chen et al, 2022), peptides (Ghareeb et al, 2020), polysaccharides (Ghareeb et al, 2020), polyketides (Ghareeb et al, 2020), and terpenes (Chen et al, 2022). Various extracts of marine organisms and/or their pure isolates exhibited a broad spectrum of bioactivities like antimicrobial (Krome et al, 2022;Liang et al, 2023), antioxidant (Catarino et al, 2023Hamed et al, 2020), anti-Gyr-B enzyme (Agour et al, 2022), antiallergic (Xie et al, 2017), antibiofilm (Cepas et al, 2019), anticancer (Agena et al, 2023;Panggabean et al, 2022), anti-inflammatory (Ghareeb et al, 2020;Rocha et al, 2022), anticoagulant (Qin et al, 2023), antiparasitic (Mostafa et al, 2022), antiallergic (Chen et al, 2023), and antiaging (Yang et al, 2023a(Yang et al, , 2023b. The marine environment is considered a strategic treasure and a huge warehouse for the production of bioactive compounds, which act as lead compounds in the pharmaceutical industry.…”

“…Natural products (NPs) have a long history in pharmacotherapy, especially in the management of cancer and infectious disturbances (Carroll et al, 2023;Chen et al, 2023). Naturally occurring bioactive chemicals have become an essential source of drugs since they have been used to treat a variety of diseases (Abdel-Aziz et al, 2018;Elkhouly et al, 2021aElkhouly et al, , 2021bMohammed et al, 2019;Yang et al, 2023aYang et al, , 2023bYeung et al, 2018). Scientists are dealing with various illnesses in our community owing to reestablished circumference and life manner.…”

Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide

“…Certain cosmetic peptides within skin cells, composed of short chains of amino acids, serve pivotal roles in cellular communication, influencing processes such as protein regulation, cell proliferation, migration, amination, angiogenesis, and melanogenesis, among others . These peptides provide a diverse array of skincare benefits, encompassing antiaging, moisturization, anti-inflammatory properties, and assistance in reinforcing the skin’s natural barrier. − Their prominence has led to their integration into an increasing number of high-end cosmetic products. Nevertheless, a significant challenge arises from the skin’s inherent barrier, which restricts the effective passage of peptides with a molecular weight exceeding 500 Da. , This limitation is because the average molecular weight of a single amino acid is approximately 110 Da, severely impeding the potential of larger peptides to exert their desired cosmetic effects.…”