Potent γ-amino butyric acid producing psychobiotic Lactococcus lactis LP-68 from non-rhizospheric soil of Syzygium cumini (Black plum)

Sharma, Pushpendra Kumar; Singh, Neera; Singh, Surender; Khare, Sunil Kumar; Nain, Pawan Kumar Singh; Nain, Lata

doi:10.1007/s00203-021-02629-4

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…After 96 hours of incubation. Can be considered for use as a starter culture for foods or supplements 34 L. reuteri DSM 17938 and ATCC PTA 6475 0.05 mM GABA produced Fermented barley 105 …”

Section: Probiotics Psychobiotics Depression and Anxietymentioning

confidence: 99%

“…Interestingly, the authors observed that GABA was not produced when MSG was not present, suggesting the importance of MSG in the production of GABA. 34 ( Table 4 )…”

Section: Probiotics Psychobiotics Depression and Anxietymentioning

confidence: 99%

“…GABA is a primary inhibitory neurotransmitter that helps regulate sleep, memory, locomotor activity, muscle relaxation, and acts as an anti-inflammatory. 8 , 15 , 31 , 32 , 33 , 34 Dysfunction in GABA has been associated with anxiety, depression, autism, panic attacks, epilepsy, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), Huntington's disease, headaches, cognitive impairment, and Alzheimer's disease, as well as affecting several aspects of health such as reducing blood pressure, suppressing appetite and easing PMS. 8 , 15 Like other neurotransmitters, the gut microbiota can produce GABA.…”

Section: Introductionmentioning

confidence: 99%

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Psychobiotics: Are they the future intervention for managing depression and anxiety? A literature review

Ross¹

2023

EXPLORE

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“…After 96 hours of incubation. Can be considered for use as a starter culture for foods or supplements 34 L. reuteri DSM 17938 and ATCC PTA 6475 0.05 mM GABA produced Fermented barley 105 …”

Section: Probiotics Psychobiotics Depression and Anxietymentioning

confidence: 99%

“…Interestingly, the authors observed that GABA was not produced when MSG was not present, suggesting the importance of MSG in the production of GABA. 34 ( Table 4 )…”

Section: Probiotics Psychobiotics Depression and Anxietymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychobiotics: Are they the future intervention for managing depression and anxiety? A literature review

Ross¹

2023

EXPLORE

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“…A study found that Lactococcus produces the highest content of γ-Aminobutyric acid (GABA), and this bacterium was selected to optimize better culture conditions (pH, temperature, and MSG). The non-protein amino acid, γ-Aminobutyric acid (GABA), rapidly accumulates in plant tissues in response to biological and abiotic stresses and regulates plant growth [32,33]. Another study on Crocus sativus showed that GABA increased the number of leaves and roots.…”

Section: Comparison Of Bacterial Diversity Activity In Different Samplesmentioning

confidence: 99%

Unraveling Complexity of Rhizosphere Microbiome Affecting on Quality of Crocus sativus

Ghayoumi¹,

Emamjomeh

Kavousi³

et al. 2022

Preprint

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Saffron (dried stigmas of Crocus sativus) is an aromatic crop belonging to Iridaceae family. The microorganisms in soil are main factors affecting the production and quality of Crocus sativus. We have studied the microbial relationships between Saffron rhizosphere and quality indices of Crocus sativus (crocin, picrocrocin, and safranal) using a Metagenomic approach. It was found that despite the similar climatic conditions, the quality of Saffron in a region is higher than other regions. This can be related to different microbes in root zone or rhizosphere layer. The purpose was to investigate and compare soil microbiome rhizosphere compared to other regions, as a result, to identify the microbiome affecting the quality of Saffron. In this research, rhizosphere soil of different regions in Ghayen(Iran), the center of high quality Saffron, was firstly sampled during harvesting time. In the next step, soil DNA was extracted, and the 16srRNA gene sequence of each sample was identified based on the RNA-Seq method; finally, the microbiome of the samples was analyzed. The results indicated that beneficial bacteria such as Kosakonia, Enterobacter, Salmonella, Plesiomonas, Pasteurella, Lactococcus, and Mitsuaria have a significant impact on increasing Saffron quality. Such bacteria, which affect the quality of Crocus sativus, increase carbon source, nitrogen fixation, auxin synthesis, dissolved phosphate production, γ-Aminobutyric acid (GABA) production, increase the activity of antioxidant enzymes and increase plant growth stimulants; and can improve the quality of Saffron.

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“…Among postbiotic metabolites, GABA is a non-protein amino acid extensively produced by LAB, such as L. brevis (Liu, Li, Liu, Ko, & Kim, 2022), L. plantarum (Kim et al, 2022b), L. rhamnosus (Song & Yu, 2018) or L. lactis (Sharma et al, 2022). The synthesis of this postbiotic compound depends on the amino acid L-glutamate (L-Glu) because it is used as a precursor of the glutamic acid decarboxylase (GAD) biosynthetic pathway (Falah, Vasiee, Tabatabaei-Yazdi, Moradi, & Sabahi, 2022).…”

Section: Introductionmentioning

confidence: 99%

Characterisation of the probiotic potential of Lactiplantibacillus plantarum K16 and its ability to produce the postbiotic metabolite γ-aminobutyric acid

Diez-Gutiérrez

Vicente

Sáenz

et al. 2022

Journal of Functional Foods

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Potent γ-amino butyric acid producing psychobiotic Lactococcus lactis LP-68 from non-rhizospheric soil of Syzygium cumini (Black plum)

Cited by 7 publications

References 43 publications

Psychobiotics: Are they the future intervention for managing depression and anxiety? A literature review

Psychobiotics: Are they the future intervention for managing depression and anxiety? A literature review

Unraveling Complexity of Rhizosphere Microbiome Affecting on Quality of Crocus sativus

Characterisation of the probiotic potential of Lactiplantibacillus plantarum K16 and its ability to produce the postbiotic metabolite γ-aminobutyric acid

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