Abstract:Blood feeding arthropods,such as leeches,ticks, flies and mosquitoes,p rovide ap rivileged source of peptidic anticoagulant molecules.T hese primarily operate through inhibition of the central coagulation protease thrombin by binding to the active site and either exosite Io re xosite II. Herein, we describe the rational design of an ovel class of trivalent thrombin inhibitors that simultaneously blockb oth exosites as well as the active site.These engineered hybrids were synthesized using tandem diselenide-sel… Show more
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