Potent antiulcerogenic activity of ethanol extract of leaf ofPiper betle Linn by antioxidative mechanism

Abstract

ABSTRACT:Pretreatment of an ethanolic extract of leaf of Piper betle finn at a dose of 200mg/ kg body weight, orally administered to rats for ten consecutive days, was found to possess a significant protective action against gastric lesions induced by indomethacin. The extract pretreatment resulted in significant increase in superoxide dismutase (SOD) and catalase (CAT) activity, increase in mucus, hexosamine and total thiol group content, but marked reduction in oxidatively damaged protein and peroxidised lipid levels as compared to untreated ulcerated control. The extract was also found to possess both superoxide and hydroxyl free radical scavenging action.The present observations establish the efficacy of the extract in prevention of experimentally induced peptic ulcer by indomethacin and antioxidant property appears to be predominantly responsible for such cytoprotective activity in the experimental model.

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

“…However, the presence of all these compounds depends on the region where it grows; the oil has been used in respiratory troubles, cataract, and also as an antiseptic [76]. Its antiulcerogenic [77,78] activity has been reported. One of its active components, the allylpyrocatechol, shows the best antiulcer activity mainly by modulation of arginase metabolism and shift of cytokine balance [79].…”

Screening for Antibacterial Properties of Three Medicinal Plants Against Salmonella Sp. Isolates Obtained From Broiler Carcass in Indonesia

“…Additionally, Piper betel leaves are also reported to contain volatile oil, such as betel phenol and chavicol, tannin, sugar, and vitamin C. Moreover, Betel's leaves possess some other activities like antidiabetic, antiulcer, antitumor (Majumdar et al, 2003) and antimicrobial (Majumdar et al, 2002;Shalini et al, 2012). Thus, the findings of these earlier researches are in accordance with the findings of this study, i.e., disclosing the antimicrobial activities of the three commonly used medicinal plants amongst the native Indonesian against the pathogenic bacteria, Salmonella sp.…”

Antioxidant effect ofPhyllanthus emblica fruits on healing of indomethacin induced gastric ulcer in rats

“…A growing body of evidences also suggest that a number of plants and plant products (eg, Ocimum sanctum Linn (19), piper betle leaves (20), rhizome of zigiber officinate (21), rhizome of picrorhiza kurrooa (22), phytlanthus emblica) are known as potent antiulurogenic properties as well as for healing ulcer and atleast part of the therapeutic values of these plant products may be ascribed to their antioxidant properties.…”