Potent antitumor antibiotic complex: PD 114,759, PD 115,028, PD 119,707, and PD 119,193.

Tunac, J. B.; Graham, Brittany D.; Mamber, Stephen W.; Dobson, W. E.; Lenzini, M. D.

doi:10.7164/antibiotics.38.1337

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…This is closely related to the reported range of 0.1% (Kojiri et al, 1992) to 0.25% (Harindran et al, 1999). Even though KCl was also used by several workers (Tunac et al, 1985;Nakamura et al, 1986) the present experiment did not support.…”

Section: Effect Of Chloridecontrasting

confidence: 92%

Fermentation Studies for the Production of Dibutyl Phthalate , an Ester Bioactive Compound from Streptomyces albidoflavus MTCC 3662 Using Low-Priced Substrates

Roy¹,

Sen²

2013

JJBS

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Attempts were made to evaluate the limiting nutritional parameters for production of dibutyl phthalate from Streptomyces albidoflavus MTCC 3662. The compound was found as a broad spectrum bioactive compound that acts as an antimetabolite of proline. Among the carbon and nitrogen sources tested in batch fermentation, glycerol (1.75%) and arginine (0.075%) supported best production. Arginine was replaced with sodium nitrate (0.025%) in the later studied due to its low cost, easy availability and as well as for good production capability. Other limiting nutrients, KH 2 PO 4 0.05%, NaCl 0.15% and MgSO 4 0.03% were found best for production. Effect of trace salts in the basal medium was also tested. Medium supplementation with casein hydrolysate, jaggery and yeast extract (0.001%, each) enhanced the production. Yield enhancement was also observed with Tween-80 (0.2µg/ml). Optimization of nutritional parameters imparts enhancement of production by 2.4 fold, using low cost substrates.

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Section: Effect Of Chloridecontrasting

confidence: 92%

Fermentation Studies for the Production of Dibutyl Phthalate , an Ester Bioactive Compound from Streptomyces albidoflavus MTCC 3662 Using Low-Priced Substrates

Roy¹,

Sen²

2013

JJBS

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“…It was isolated in 1983 from the fermentation broth of a Brazilian actinomycete identified as Streptomyces pulveraceus ATCC 31906, subspecies fostreus . 7 The isolation procedure had to be carried out in the 5.5 < pH < 7.5 range due to fostriecin ( 1 ) instability. The two-dimensional structure of its monosodium salt was established based on chemical degradations and nuclear magnetic resonance spectroscopy.…”

Section: Isolation Structural Diversity and Pharmacological And Biolo...mentioning

confidence: 99%

The phosphate ester group in secondary metabolites

2022

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“…Chemicals PD 114,759, PD 115,028, PD 119,193 and PD 119,707 were isolated as previously described (1).…”

Section: Methodsmentioning

confidence: 99%

“…(ATCC 39363) (1). These unique, sulfur containing compounds have been shown to be extremely potent having IC50 values for the inhibition of tumor cell growth in vitro in the range of 10 -13 -10 -12 M and exhibit antitumor activity against P388 leukemia in vivo at doses ranging from 4-50/zg/kg (1,2). Wilton, G.C.…”

Section: Introductionmentioning

confidence: 99%

Biological and biochemical activities of the novel antitumor antibiotic PD 114,759 and related derivatives

Fry¹,

Shillis²,

Leopold³

1986

Invest New Drugs

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A complex of novel and exceptionally potent antibiotics has been evaluated for antitumor activity in vitro and in vivo and characterized with regard to their ability to cause DNA strand scission. The major component, PD 114,759, was quite active against all in vitro tumor systems including the human tumors, MCF-7 breast, HCT-8 colon, and A549 lung and the murine tumors M16/c mammary, Lewis lung, Pan 02 pancreas and L1210 leukemia. ID50 values ranged from 2-57 pg/ml. In vivo this agent produced significant increases of host life spans in mice bearing L1210 leukemia, B16 melanoma and the M5076 sarcoma. Further, it inhibited growth of subcutaneous implants of the Ridgway osteogenic sarcoma by 80% and growth of the MX-1 human mammary xenograft by 90-95%. PD 114,759, however, had no activity against the colon adenocarcinoma 11a or mammary adenocarcinoma 16c. Chinese hamster ovary cells exposed for 24 hours to concentrations of PD 114,759 ranging from 18 to 37 pg/ml accumulated in the S and G2+M phases of the cell cycle with a corresponding decrease in G1. Higher concentrations of drug apparently stopped any progression through the cell cycle. PD 114,759 caused significant DNA single strand breaks in L1210 cells exposed for 1 hour to drug concentrations as low as 20 pg/ml and the frequency of these lesions increased in proportion to the drug concentration. A portion of these DNA breaks appeared to be associated with protein. In contrast, no double strand DNA breaks were detected at the highest drug concentration tested (100 pg/ml).

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Potent antitumor antibiotic complex: PD 114,759, PD 115,028, PD 119,707, and PD 119,193.

Cited by 10 publications

References 8 publications

Fermentation Studies for the Production of Dibutyl Phthalate , an Ester Bioactive Compound from Streptomyces albidoflavus MTCC 3662 Using Low-Priced Substrates

Fermentation Studies for the Production of Dibutyl Phthalate , an Ester Bioactive Compound from Streptomyces albidoflavus MTCC 3662 Using Low-Priced Substrates

The phosphate ester group in secondary metabolites

Biological and biochemical activities of the novel antitumor antibiotic PD 114,759 and related derivatives

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