Potent Antioxidant Agents: Dithiocarbamates of Ω-Substituted (2-Naphthyloxy) Alkanes

Abstract

A series of dithiocarbamates of ω-substituted (2-naphthyloxy) alkanes (4-48) was tested for antioxidant activity by radicals 2,2-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) assay, DPPH assay (1,1-diphenyl-2-picryl-hydrazyl), O2. (NET) assay and ROO. (TRAP) assay against curcumin and vitamin C as standard drugs. Most of these compounds have shown promising activities, such compounds are 11, 12, 13, 25, 26, 27, 28, 41, 42, and 43. The series was synthesized by the condensation reaction of 2-(2-chloro-alkoxy)-naphthalene with different types of aliphatic, alicyclic, aromatic, heterocyclic primary, as well as secondary amines to develop dithiocarbamates of ω-substituted (2-naphthyloxy) alkanes.