Potent Anti-Inflammatory Activity of Pyrenocine A Isolated from the Marine-Derived FungusPenicillium paxilliMa(G)K

Abstract

Very little is known about the immunomodulatory potential of secondary metabolites isolated from marine microorganisms. In the present study, we characterized pyrenocine A, which is produced by the marine-derived fungus Penicillium paxilli Ma(G)K and possesses anti-inflammatory activity. Pyrenocine A was able to suppress, both pretreatment and posttreatment, the LPS-induced activation of macrophages via the inhibition of nitrite production and the synthesis of inflammatory cytokines and PGE2. Pyrenocine A also exhibited anti-inflammatory effects on the expression of receptors directly related to cell migration (Mac-1) as well as costimulatory molecules involved in lymphocyte activation (B7.1). Nitrite production was inhibited by pyrenocine A in macrophages stimulated with CpG but not Poly I:C, suggesting that pyrenocine A acts through the MyD88-dependent intracellular signaling pathway. Moreover, pyrenocine A is also able to inhibit the expression of genes related to NFκB-mediated signal transduction on macrophages stimulated by LPS. Our results indicate that pyrenocine A has promissory anti-inflammatory properties and additional experiments are necessary to confirm this finding in vivo model.

Investigation of anti‐inflammatory and toxicity effects of mangrove‐derived Streptomyces rochei strain VITGAP173

“…showed immunosuppressive and anti‐inflammatory activity . Marine fungus has also been a source for few anti‐inflammatory compounds such as mangicols A and B (sesterterpenes), mycoepoxidiene, penstyrylpyrone, and pyrenocine A . However, the present study revealed the anti‐inflammatory efficacy of the potential strain VITGAP173 isolated from Pichavaram regions.…”

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators

“…It is worth mentioning that inflammatory cytokines have stimulated [ 62 , 63 , 64 , 65 ] cells to synthesize other inflammatory cytokines, namely, IL-1β, TNF-α, IL-6, IL-8, and chemokines. The anti-inflammatory cytokines are a series of immune-regulatory molecules [ 34 , 50 , 66 , 67 ] that control the pro-inflammatory cytokine response.…”

A Strategy for the Rapid Identification of Fungal Metabolites and the Discovery of the Antiviral Activity of Pyrenocine a and Harzianopyridone

“…Compound (28) was identified as 6,7-dihydroxy-2,2-dimethyl-4-chromanone, first synthesized in 1937. 38 Related compounds displayed antioxidant activity and are used as inhibitors of self-oxidation of various organic substrates such as plastics, lubricants and rubber products often exposed to air during manufacturing processes. 38,39 Production of (28) by Cochliobolus spp.…”