Potent and Specific Bactericidal Effect of Juglone (5-Hydroxy-1,4-naphthoquinone) on the Fire Blight Pathogen Erwinia amylovora

Fischer, Thilo C.; Gosch, Christian; Mirbeth, Beate; Gselmann, Markus Werner; Thallmair, Veronika; Stich, Karl

doi:10.1021/jf303584r

Cited by 21 publications

(12 citation statements)

References 31 publications

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“…Supporting this notion, juglone has been shown to be a potent and specific inhibitor of the growth of the fire blight pathogen, Erwinia amylovara . 185 Similarly, it was reported that plumbagin is a potent growth inhibitor of a number of phytopathogenic fungi. 186…”

Section: Biochemical Perspectives On the Functions Of Specialized 14mentioning

confidence: 96%

Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants

2016

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The 1,4-naphthoquinones (1,4-NQs) are a diverse group of natural products found in every kingdom of life. Plants, including many horticultural species, collectively synthesize hundreds of specialized 1,4-NQs with ecological roles in plant–plant (allelopathy), plant–insect and plant–microbe interactions. Numerous horticultural plants producing 1,4-NQs have also served as sources of traditional medicines for hundreds of years. As a result, horticultural species have been at the forefront of many basic studies conducted to understand the metabolism and function of specialized plant 1,4-NQs. Several 1,4-NQ natural products derived from horticultural plants have also emerged as promising scaffolds for developing new drugs. In this review, the current understanding of the core metabolic pathways leading to plant 1,4-NQs is provided with additional emphasis on downstream natural products originating from horticultural species. An overview on the biochemical mechanisms of action, both from an ecological and pharmacological perspective, of 1,4-NQs derived from horticultural plants is also provided. In addition, future directions for improving basic knowledge about plant 1,4-NQ metabolism are discussed.

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Section: Biochemical Perspectives On the Functions Of Specialized 14mentioning

confidence: 96%

Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants

2016

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“…Several articles have been published on the antibacterial activities of juglone against a number of bacteria ranging from those that affect animal guts to those that contaminate livestock products to others that represent plant pathogens [54][55][56][57][58][59][60][61][62]. Clark et al [63], reported that juglone has moderate inhibitory activity against Gram-positive and acid-fast bacteria, and little activity against Gram-negative bacteria.…”

Section: Bactericidal Propertiesmentioning

confidence: 99%

Agricultural Uses of Juglone: Opportunities and Challenges

Islam

Widhalm

2020

Agronomy

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Application of conventional synthetic pesticides and agrochemicals has boosted the yield and productivity of crops by reducing pest infestation and promoting crop growth yet increasing reliance on many of these products poses serious environmental threats. This has led to growing interest in obtaining more environmentally friendly alternatives to conventional pesticides and agrochemicals. Allelochemicals produced by plants, fungi, and microbes offer options for developing novel natural product-based pesticides and agrochemicals that are effective but with lower environmental half-lives. Here, we review the current state of knowledge about the potential use of juglone (5-hydroxy-1,4-naphthoquinone), the allelochemical produced by black walnut trees (Juglans nigra), which has been investigated for applications across a range of different agricultural purposes. We then offer our perspective on what opportunities and challenges exist for harnessing juglone as a component of sustainable agriculture.

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“…3). P. fluorescens a close relative to P. aeruginosa that has homologues of paAzoR1–3 (Table 3) is insensitive to Jug [49] which is rapidly reduced by paAzoR2 (Fig. 3b).…”

Section: Resultsmentioning

confidence: 99%

Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes

et al. 2014

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Water soluble quinones are a group of cytotoxic anti-bacterial compounds that are secreted by many species of plants, invertebrates, fungi and bacteria. Studies in a number of species have shown the importance of quinones in response to pathogenic bacteria of the genus Pseudomonas. Two electron reduction is an important mechanism of quinone detoxification as it generates the less toxic quinol. In most organisms this reaction is carried out by a group of flavoenzymes known as NAD(P)H quinone oxidoreductases. Azoreductases have previously been separate from this group, however using azoreductases from Pseudomonas aeruginosa we show that they can rapidly reduce quinones. Azoreductases from the same organism are also shown to have distinct substrate specificity profiles allowing them to reduce a wide range of quinones. The azoreductase family is also shown to be more extensive than originally thought, due to the large sequence divergence amongst its members. As both NAD(P)H quinone oxidoreductases and azoreductases have related reaction mechanisms it is proposed that they form an enzyme superfamily. The ubiquitous and diverse nature of azoreductases alongside their broad substrate specificity, indicates they play a wide role in cellular survival under adverse conditions.

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Potent and Specific Bactericidal Effect of Juglone (5-Hydroxy-1,4-naphthoquinone) on the Fire Blight Pathogen Erwinia amylovora

Cited by 21 publications

References 31 publications

Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants

Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants

Agricultural Uses of Juglone: Opportunities and Challenges

Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes

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