Potensi Tumbuhan Koleksi Kebun Raya Cibodas Sebagai Obat Antimalaria Masa Depan

Lailaty, Intani Quarta; Muhaimin, Muhamad; Handayani, Aisyah; Efendi, Muhammad; Nadhifah, Ainun; Noviady, Ikhsan

doi:10.22435/toi.v9i1.6391.37-57

Cited by 2 publications

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“…termasuk ke dalam keluarga Asteraceae dimana ciri-ciri tumbuhan semak hutan yang tingginya hingga 7 meter. Tumbuhan ini memiliki karakteristik rasa pahit sehingga diberi nama daun pahit (Lailaty, 2016).…”

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Studi Literatur Aktivitas Antimalaria Tanaman Afrika (Vernonia amygdalina Del.)

Astuti

Fitrianingsih

Suwendar

2022

BCSP

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Abstract. Malaria is a public health problem in various parts of the world, because malaria causes death in infants, toddlers, pregnant women and adults and can have an impact on social development. The prevalence of malaria in Indonesia in 2019 was 250,644 cases. Most cases almost occurred in Papua, around 86% with a total of 216,380 cases. The second area with the most malaria cases is East Nusa Tenggara with 12,909 cases and West Papua with 7,079 cases. The use of antimalarial drugs with herbal plants has been used by the community empirically, due to the presence of antimalarial drug resistance, especially in malaria endemic areas. So it is necessary to have antimalarial medicinal plants that can be developed into antimalarial herbal medicines. There are many plants that have antimalarial activity, one of which is the African plant (Vernonia amygdalina Del.). There are many plants that have antimalarial activity, one of which is the African plant (Vernonia amygdalina Del.). The purpose of this literature study was to determine the level of antimalarial activity of African plants and to determine the content of secondary metabolites that are efficacious as antimalarials. The research was conducted using the Systematic Literature Review (SLR) method in reputable journals using the keyword Vernonia amygdalina Del antimalarial. The results of the literature study showed that the African plant parts, namely the leaves from the cyclohexane extract with the maceration method, could inhibit the Plasmodium falciparum parasite with an IC50 value of 4.34 g/ml in the very category and the aqueous extract with the maceration method could inhibit the growth of the Plasmodium berghei parasite with % inhibition. by 70.87% with very active category. African plants contain secondary metabolites from the terpenoid group, namely vernodalol and vernolide with IC50 values <10. Abstrak. Penyakit malaria merupakan masalah kesehatan masyarakat di berbagai belahan dunia, karena penyakit malaria menyebabkan kematian pada bayi, balita, ibu hamil dan orang dewasa juga dapat berdampak pada perkembangan sosial. Prevalensi mengenai penyakit malaria yang terjadi di Indonesia pada tahun 2019 yaitu sebanyak 250.644 kasus. Sebagian kasus hampir terjadi di daerah Papua sekitar 86% dengan jumlah 216.380 kasus. Daerah kedua dengan kasus malaria terbanyak yaitu Nusa Tenggara Timur dengan jumlah kasus sebanyak 12.909 kasus dan Papua Barat dengan jumlah kasus 7.079 kasus. Penggunaan obat antimalaria dengan tanaman herbal telah digunakan oleh masyarakat secara empiris, karena adanya resistensi obat antimalaria terutama didaerah endemik malaria. Sehingga diperlukan adanya tumbuhan obat antimalaria yang dapat dikembangkan menjadi obat herbal antimalaria.Terdapat banyak tanaman yang memiliki aktivitas antimalaria salah satunya adalah tanaman afrika (Vernonia amygdalina Del.). Tujuan dari studi literatur ini adalah untuk mengetahui tingkat aktivitas antimalarial tanaman afrika dan mengetahui kandungan metabolit sekunder yang berkhasiat sebagai antimalaria. Penelitian dilakukan dengan metode Systematic Literatur Review (SLR) pada jurnal bereputasi menggunakan kata kunci Vernonia amygdalina Del. antimalarial. Hasil studi literatur menunjukkan bahwa bagian tanaman afrika yakni daun dari mulai ekstrak sikloheksana dengan metode maserasi dapat menghambat parasit Plasmodium falciparum dengan nilai IC50 sebesar 4,34 µg/ml dengan kategori sangat aktif dan ekstrak air dengan metode maserasi dapat menghambat pertumbuhan parasit Plasmodium berghei dengan %hambatannya sebesar 70,87% dengan kategori sangat aktif. Pada tanaman afrika terkandung metabolit sekunder dari golongan terpenoid yaitu vernodalol dan vernolide dengan nilai IC50<10.

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Section: Aunclassified

Studi Literatur Aktivitas Antimalaria Tanaman Afrika (Vernonia amygdalina Del.)

Astuti

Fitrianingsih

Suwendar

2022

BCSP

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“…This plant is a small shrub, which has been widely planted by people in Indonesia, especially in East Kalimantan due to its potents as medicinal plants (Duarte and Silva 2013). This plant has potential as an antidiabetic drug (Atangwho 2014;Mustofa et al 2020), antimalarial drug (Lailaty et al 2016). It also contains antioxidative and chemopreventive properties (Farombi and Owoeye 2011;Asante et al 2016;Okoduwa et al 2017), antioxidants (Atangwho 2013), antibacterial (Uzoigwe and Agwa 2011), antifungal (Yusoff et al 2018;Praptiwi et al 2020).…”

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confidence: 99%

The application of NPK fertilizer boosts the nutrient uptake status and biomass production of Vernonia amygdalina

Susanto

Amirta

2020

Nusantara Biosci

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Abstract. Susanto D, Amirta R. 2020. The application of NPK fertilizer boosts the nutrient uptake status and biomass production of Vernonia amygdalina. Nusantara Bioscience 12: 114-119. Vernonia amygdalina Delile is a medicinal plant introduced in Indonesia. This study aims to determine the nutrients absorption status and growth of V. amygdalina plants planted with a spacing of 1x1 m. The study used a complete randomized block design with NPK compound fertilizer treatment with five doses of fertilizer namely 0 g (without fertilizer) as a control, 40 g, 80 g, 120 g, and 140 g, three blocks each group consisted of 10 plants so that in total there were 150 plants. The results showed that NPK fertilizer increased growth and the biomass of V. amygdalina. The best growth of V. amygdalina plant was achieved in plants applied with 160g per plant NPK fertilizer in which the average of stem diameter and plant height were 6.69 ± 0.930 cm and 611.67 ± 12.71 cm, while the estimated biomass yield was 407 tons.ha-1. The most nutritional elements accumulated in plant biomass was the calcium (1279.49 kg.ha-1), followed by magnesium (1167.0642 kg.ha-1), phosphorus (536.64 kg.ha-1), potassium (419.71 kg.ha-1) and nitrogen (134.4 kg.ha-1). We propose that these base nutrients are highly necessary for the cultivation of V. amygdalina as biomass feedstock or medicine plant.

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Potensi Tumbuhan Koleksi Kebun Raya Cibodas Sebagai Obat Antimalaria Masa Depan

Cited by 2 publications

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Studi Literatur Aktivitas Antimalaria Tanaman Afrika (Vernonia amygdalina Del.)

Studi Literatur Aktivitas Antimalaria Tanaman Afrika (Vernonia amygdalina Del.)

The application of NPK fertilizer boosts the nutrient uptake status and biomass production of Vernonia amygdalina

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