Potency of non-steroidal anti-inflammatory drugs in chemotherapy

Hiľovská, Lucia; Jendželovský, Rastislav; Fedoročko, Peter

doi:10.3892/mco.2014.446

Cited by 54 publications

(37 citation statements)

References 145 publications

(143 reference statements)

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“…This concept is consistent with the anti-inflammatory benefits of homeopathy and other CAM modalities. It is also supported by the observed worsening of symptoms in Alzheimer's disease patients [29], and yet a slowing of tumor growth in cancer patients [30] receiving non-steroidal anti-inflammatory medications. Energy seeking self-directed inflammation may possibly provoke a perpetuating autoimmunity against normal tissues.…”

Section: Cancer and Inflammationmentioning

confidence: 84%

Alternative Cellular Energy as a Unifying Concept in Complementary Alternative Medicine

Martin¹

2015

IJCAM

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Energy allows cells to function and an insufficiency of cellular energy (ICE) explains many disease processes. Food metabolism has generally been viewed as providing the energy required for cellular functions, with additional direct energy input available for plants and certain bacterial through photosynthesis. This view can now be expanded with the description of the third or alternative cellular energy (ACE) pathway. The clinical benefits of several major modalities of complementary alternative medicine (CAM) may be explained as enhancing the ACE pathway. Further progress in this area should help minimize the future need for pharmaceuticals. It will also lead to a better understanding of the body as an antenna for absorbing a proposed natural energy force termed KELEA (kinetic energy limiting electrostatic attraction).

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Section: Cancer and Inflammationmentioning

confidence: 84%

Alternative Cellular Energy as a Unifying Concept in Complementary Alternative Medicine

Martin¹

2015

IJCAM

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“…[16][17][18][19] Low-dose aspirin can inhibit cancer-induced angiogenesis in several models. 20 Additionally, taking high-dose aspirin led to a lower risk of prostate cancer-specific mortality, compared with low-dose users. 21 It is of much interest to use aspirin in cancer prevention and antimetastasis therapy due to its safe long-term treatment, which is a requirement for antimetastatic drugs.…”

Section: Introductionmentioning

confidence: 99%

Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-κB/VCAM-1 pathway in human lymphatic endothelial cells

et al. 2018

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Lymphangiogenesis is the process of new vessel formation from pre-existing lymphatic vessels. The process mainly involves cell adhesion, migration, and tubule formation of lymphatic endothelial cells. Tumor-induced lymphangiogenesis is an important factor contributing to promotion of tumor growth and cancer metastasis via the lymphatic system. Finding the non-toxic agents that can prevent or inhibit lymphangiogenesis may lead to blocking of lymphatic metastasis. Recently, aspirin, a non-steroidal anti-inflammatory drug (NSAID), has been reported to inhibit in vivo lymphangiogenesis in tumor and incision wound models, but the mechanisms of actions of aspirin on anti-lymphangiogenesis have been less explored. In this study, we aim to explore the mechanism underlying the anti-lymphangiogenic effects of aspirin in primary human dermal lymphatic microvascular endothelial (HMVEC-dLy) cells in vitro. Pretreatment of aspirin at non-toxic dose 0.3 mM significantly suppressed in vitro cord formation, adhesion, and the migration abilities of the HMVEC-dLy cells. Western blotting analysis indicated that aspirin decreased expression of vascular cell adhesion molecule-1 (VCAM-1), at both protein and mRNA levels, and these correlated with the reduction of NF-κB p65 phosphorylation. By using NF-κB inhibitor (BAY-11-7085) and VCAM-1 siRNA, we showed that VCAM-1 expression is downstream of NF-κB activation, and this NF-κB/VCAM-1 signaling pathway controls cord formation, adhesion, and the migration abilities of the HMVEC-dLy cells. In summary, we demonstrate the potential of aspirin as an anti-lymphangiogenic agent, and elucidate its mechanism of action.

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“…Glucocorticosteroid therapy or non-steroidal anti-inflammatory drugs (NSAIL) usually were used to treat pain and inflammation. Literature findings show NSAIL as an anticancer drug, with good results in treatment of recurrent desmoid tumors [16,25,26]. In our patient we used similar combination of drugs postoperatively, in duration of one year, and had not observed any toxic effect.…”

Section: Discussionmentioning

confidence: 88%

Limb Salvage Treatment of Large Multicentric Extra-Abdominal Desmoid Tumor of Lower Extremity

2017

JACCOA

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This article presents a case report of large isolated extra-abdominal desmoid tumor on ipsilateral knee and ankle joint, which was successful treated with combination of surgical -limb salvage procedure and oncologist therapy in the form of hormone and anti-infammatory therapy. A 36 years old male comes, five years after primary treatment of tumor mass of the anterior abdominal wall to Department of Orthopedic surgery because he has new two large tumor changes in the front of the right knee (approximate dimensions 26x10x22 cm (CCxLLxAP)) and ankle joint (16 x 5 cm (APxLL)), which have been progressively increased over the time. The optimal management of desmoid tumor has not be established, because this tumor entity is rare and all recommendations for treatment come from the individual cases described in the literature. Combination of surgery, postoperative hormone and anti-inflammatory therapy is best way of treatment for non resectable tumors.

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Potency of non-steroidal anti-inflammatory drugs in chemotherapy

Abstract: Abstract. Cancer cell resistance, particularly multidrug resistance (MDR), is the leading cause of chemotherapy failure.

Cited by 54 publications

References 145 publications

Alternative Cellular Energy as a Unifying Concept in Complementary Alternative Medicine

Alternative Cellular Energy as a Unifying Concept in Complementary Alternative Medicine

Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-κB/VCAM-1 pathway in human lymphatic endothelial cells

Limb Salvage Treatment of Large Multicentric Extra-Abdominal Desmoid Tumor of Lower Extremity

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