Potency of extracts of selected plant species from Mbeere, Embu County-Kenya against Mycobacterium tuberculosis

Njeru, Sospeter Ngoci; Obonyo, Meshack

doi:10.5897/jmpr2016.6044

Cited by 10 publications

(9 citation statements)

References 34 publications

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“…ex Miq. Urticaceae Munyango (Luganda) Herb Leaves Uganda [ 7 ] Garcinia buchananii Baker Clusiaceae Musaali (Luganda) Tree Stem bark, Root bark Uganda, Kenya, Tanzania [ 7 , 10 , 12 ] Gnaphalium purpureum L. Asteraceae Omuya (Luganda) Herb Leaves Uganda [ 7 ] Gnidia buchananii Gilg Thymelaeaceae Not reported Herb Roots Kenya [ 49 ] Gomphocarpus physocarpus E. Mey. Apocynaceae Gashaho Herb Leaves Uganda [ 10 ] Gutenbergia cordifolia Benth.…”

Section: Resultsmentioning

confidence: 99%

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

et al. 2020

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Objective Many studies on the treatment of tuberculosis (TB) using herbal medicines have been undertaken in recent decades in East Africa. The details, however, are highly fragmented. The purpose of this study was to provide a comprehensive overview of the reported medicinal plants used to manage TB symptoms, and to analyze scientific reports on their effectiveness and safety. Method A comprehensive literature search was performed in the major electronic databases regarding medicinal plants used in the management of TB in East Africa. A total of 44 reports were retrieved, and data were collected on various aspects of the medicinal plants such as botanical name, family, local names, part(s) used, method of preparation, efficacy, toxicity, and phytochemistry. The data were summarized into percentages and frequencies which were presented as tables and graphs. Results A total of 195 species of plants belonging to 68 families and 144 genera were identified. Most encountered species were from Fabaceae (42.6%), Lamiaceae (19.1%), Asteraceae (16.2%), and Euphorbiaceae (14.7%) families. Only 36 medicinal plants (18.5%) have been screened for antimycobacterial activity. Out of these, 31 (86.1%) were reported to be bioactive with minimum inhibitory concentrations ranging from 47 to 12,500 μg/ml. Most tested plant extracts were found to have acceptable acute toxicity profiles with cytotoxic concentrations on normal mammalian cells greater than 200 μg/ml. The most commonly reported phytochemicals were flavonoids, terpenoids, alkaloids, saponins, cardiac glycosides, and phenols. Only Tetradenia riparia , Warburgia ugandensis , and Zanthoxylum leprieurii have further undergone isolation and characterization of the pure bioactive compounds. Conclusion East Africa has a rich diversity of medicinal plants that have been reported to be effective in the management of symptoms of TB. More validation studies are required to promote the discovery of antimycobacterial drugs and to provide evidence for standardization of herbal medicine use.

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Section: Resultsmentioning

confidence: 99%

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

et al. 2020

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“…Same authors also identified tannins, saponins and sterols in the stem bark extracts of the species. Dichrostachys cinerea extracts demonstrated antituberculous activities which could be attributed to the presence of bioactive compounds such as alkaloids, diterpenes, flavonoid, phytosterols, tannis and triterpenes [34]. Similarly, Peltophorum africanum bark and root extracts exhibited antibacterial activities against the respiratory infections strains Staphylococcus aureus, Streptococcus pyogenes and Klebsiella pneumoniae [35].…”

Section: Fidelity Level (Fl) and Use Value (Uv)mentioning

confidence: 99%

Ethnomedicinal Uses of Fabaceae Species for Respiratory Infections and Related Symptoms in the Limpopo Province, South Africa

Semenya

Maroyi

2018

J. Pharm. Nutr. Sci.

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Purpose: The present study investigated utilisation of Fabaceae species as herbal medicines for respiratory infections and related symptoms in the Limpopo Province, South Africa.Methods: Information on Fabaceae species used as herbal medicines against respiratory infections was gathered using semi-structured questionnaires during face-to-face interviews with 240 Pedi speaking traditional healers (THs) from May to July 2017. Voucher specimens of utilized plant species were collected and their identities and scientific names authenticated by a plant taxonomist at the University of Limpopo’s Larry Leach Herbarium.Results: Twenty-five plant species belonging to 16 genera were used by THs in treating 13 respiratory infections. Majority of the species (64.0%, n=16) were multi-used while 36.0% (n=9) treated a single condition each. Plants which showed the highest fidelity level (FL) scores included Acacia senegal (chronic cough=FL; 32.8, chest pain=FL; 32.8, tuberculosis=FL; 32.8), Dichrostachys cinerea (tuberculosis= FL; 100) and Acacia erioloba (pneumonia=FL; 92.7). These species were also characterized by high use value (UV) indices of 2.5, 0.82 and 0.58, respectively.Conclusion: Some of the plants recorded in this study are reported in literature to have potent biological activities against diverse pathogens which cause respiratory infections and perceived symptoms.

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“…In East Tropical Africa, E. ingens is used for the treatment of snakebites (Ernst et al, 2015). In addition to its traditional medicinal uses, there are reports on its ichthyocidal, antituberculous, antimicrobial and antifungal activities (Kena, 2016;Njeru and Meshack, 2016;Ross and Steyn, 2004).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and gas chromatography-mass spectrometry analysis of Euphorbia ingens organic root extract

Innocent¹,

Florence²,

Mutinda³

et al. 2023

J. Med. Plants Res.

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Euphorbia ingens is a woody, succulent tree with ethnomedicinal applications; however, its chemical constituents are not well documented. This study determined the phytochemical profile of Euphorbia ingens dichloromethane-methanol root bark extract. Following sample collection and preparation, extraction was done using the cold percolation technique. This was followed by qualitative phytochemical screening and gas chromatography-mass spectrometry (GC-MS) analysis. This study reports relative high abundance of phenols, tannins and saponins with moderate and low levels of flavonoids and terpenoids respectively in E. ingens dichloromethane-methanol root bark extract. However, alkaloids, quinones and sterols were not identified in this study. Additionally, 14 phytocompounds were identified through GC-MS analysis, including undecane; copaene; 3,4-altrosan; 9, 12, 15-octadecatrienoic acid; hexadecanoic acid; 1,2-benzenedicarboxylic acid; lanosterol; androst-2en-17-one; lanosterol; 2-Bornanol; octadecanoic acid; squalene; 6-Pentylidene-4,5-secoandrostane-4,17.beta.-diol, and ethyl trans-4a, cis-4b, trans-8a, cis-10a-perhydro-trans-2,4a,8a-trimethyl-8oxophenanthrene-2-carbothiolate. These phytocompounds have been documented to have diverse pharmacological activities from antimicrobial, antioxidant, anticancer, hypercholesterolemic and antiinflammatory activities. Therefore, it was assumed in this study that these phytocompounds could be responsible for documented E. ingens pharmacological activities. Thus, the results of this study could support to some extent the ethnomedical uses of E. ingens. However, further biological investigations to validate the reported ethnobotanical uses of E. ingens are required.

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Potency of extracts of selected plant species from Mbeere, Embu County-Kenya against Mycobacterium tuberculosis

Cited by 10 publications

References 34 publications

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Ethnomedicinal Uses of Fabaceae Species for Respiratory Infections and Related Symptoms in the Limpopo Province, South Africa

Phytochemical screening and gas chromatography-mass spectrometry analysis of Euphorbia ingens organic root extract

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