Potency and spectrum of tigecycline tested against an international collection of bacterial pathogens associated with skin and soft tissue infections (2000–2004)

Fritsche, Thomas R.; Sader, Hélio S.; Stilwell, Matthew G.; Dowzicky, M.; Jones, Ronald N.

doi:10.1016/j.diagmicrobio.2005.05.003

Cited by 56 publications

(37 citation statements)

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“…tigecycline disk diffusion breakpoints was slightly more tigecycline resistant (2.9%) than those of other published studies (0.0 to 1.6% resistant) ( Table 2). The tigecycline MIC 90 results ranged from 2 to 4 g/ml (8,9,19,22,23), and the percentage of isolates with a tigecycline MIC at Յ2 g/ml was 86.7 to 96.7%. Generally, Acinetobacter sp.…”

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confidence: 99%

“…Table 2 shows tigecycline activities tested by reference methods against more than 800 strains of Acinetobacter spp. reported in other studies (8,9,19,22,23). The collection used in this study to determine the Acinetobacter sp.…”

mentioning

confidence: 99%

“…Also, the tigecycline MIC distribution and percentage of Acinetobacter sp. strains inhibited at Յ2 g/ml for the collection were compared to those reported in four distinct surveillance reports (8,9,22,23). Figure 1 shows the scattergram of tigecycline MIC results versus zone diameters around 15-g disks.…”

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confidence: 99%

“…Nevertheless, tigecycline clearly displays inhibitory activity against Acinetobacter spp. (2,8,9,13,17,19,22,23) and has been utilized for therapy against MDR strains despite the lack of a U.S. FDAapproved clinical indication and interpretive criteria for in vitro susceptibility testing (5, 5a, 11, 13 (24) and tested for susceptibility by CLSI methods (3-5) using freshly prepared (Ͻ12-h-old) cation-adjusted Mueller-Hinton medium (2, 21) for frozen-form broth microdilution tests (TREK Diagnostics, Cleveland, Ohio). Tigecycline disks were used (15 g; lot no.…”

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confidence: 99%

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Multicenter Studies of Tigecycline Disk Diffusion Susceptibility Results for Acinetobacter spp

et al. 2007

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Acinetobacter sp. isolates having multidrug resistance (MDR) patterns have become common in many medical centers worldwide, limiting therapeutic options. A five-center study tested 103 contemporary clinical Acinetobacter spp., including MDR strains, by reference broth microdilution and disk diffusion (15-g disk content) methods against tigecycline. Applying U.S. Food and Drug Administration tigecycline breakpoint criteria for Enterobacteriaceae (susceptibility at <2 g/ml [<1 g/ml by the European Committee on Antimicrobial Susceptibility Testing]; disk diffusion breakpoints at >19 mm and <14 mm) to Acinetobacter spp. led to an unacceptable error rate (23.3%). However, an adjustment of tigecycline disk diffusion breakpoints (susceptible/resistant) to >16/<12 mm reduced intermethod errors to an acceptable level (only 9.7%, all minor).

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confidence: 99%

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confidence: 99%

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Multicenter Studies of Tigecycline Disk Diffusion Susceptibility Results for Acinetobacter spp

et al. 2007

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“…Treatment of complicated intra-abdominal and complicated skin and soft tissue infections may contribute to the emergence and selection of multidrug-resistant bacterial strains in health care centres [18]. Although antibiotic resistance occurs in various hospital wards and clinics, it is best documented in the ICU.…”

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confidence: 99%

Susceptibility to tigecycline of Acinetobacter baumannii strains isolated from intensive care unit patients

Talaga

Krzyściak

Bulanda

2016

Anaesthesiol Intensive Ther

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Background: Infections caused by Acinetobacter baumannii are difficult to cure due to the acquisition of resistance by these bacteria and lead to an increase in the general costs of hospitalization. The aim of this study was to determine tigecycline susceptibility of Acinetobacter baumannii strains isolated from intensive care unit and non-intensive care unit patients with skin and soft tissue infections. Methods: MICs were tested by Etest among 70 Acinetobacter baumannii isolates. Results: The MIC range was from 0.5 to 8.0 mg L -1 . For ESBL-producing Acinetobacter baumannii, as well as for strains without carbapenemases, the highest MIC to tigecycline value was 8.0 mg L -1 . For AmpC-producing Acinetobacter baumannii, the highest MIC to tigecycline value was 6.0 mg L -1 and, for MBL-producing strains, 2.0 mg L -1 . Conclusions:The majority of Acinetobacter baumannii strains isolated from ICU and non-ICU patients demonstrated high values of MIC range, MIC 50 and MIC 90 to tigecycline.

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Resistance of Gram-negative Bacilli to Antimicrobials

Dean¹,

Pascale²,

Benton³

2018

Antimicrobial Resistance in the 21st Century

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Potency and spectrum of tigecycline tested against an international collection of bacterial pathogens associated with skin and soft tissue infections (2000–2004)

Cited by 56 publications

References 30 publications

Multicenter Studies of Tigecycline Disk Diffusion Susceptibility Results for Acinetobacter spp

Multicenter Studies of Tigecycline Disk Diffusion Susceptibility Results for Acinetobacter spp

Susceptibility to tigecycline of Acinetobacter baumannii strains isolated from intensive care unit patients

Resistance of Gram-negative Bacilli to Antimicrobials

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