Potency after unilateral nerve sparing surgery: a report on functional and oncological results of unilateral nerve sparing surgery

Aa, Frank Van der; Joniau, Steven; Ridder, Dirk De; Poppel, Hendrik Van

doi:10.1038/sj.pcan.4500626

Cited by 24 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While it is generally wellrecognized that common surgeries for breast cancer, i.e., mastectomy and/or lymph node dissection, can cause lymphedema and result in loss of function of the arm, as well as cosmetic issues [9], there have been only two reports of age influencing this outcome, one suggesting that increasing age is a risk factor for lymphedema [10] and the other suggesting that it is protective [11]. In contrast, several studies have investigated urinary incontinence and impotence after prostatectomy in both older and younger men, with most suggesting that increasing age is associated with higher risk of these adverse sequelae [12][13][14][15][16][17][18], and only one study observing no effect [19]. Age-related outcomes for abdominal surgery are less well-known, though complications include intestinal obstruction from adhesions, and short bowel syndrome.…”

Section: Sequelae Specifically Related To Surgerymentioning

confidence: 91%

The older cancer survivor

Rao

Demark‐Wahnefried

2006

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Section: Sequelae Specifically Related To Surgerymentioning

confidence: 91%

The older cancer survivor

Rao

Demark‐Wahnefried

2006

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

“…The anatomical techniques used in RRP results in decreased blood loss and thus better visualization and safer dissection of the neurovascular bundles [2,3]. Many studies on erectile dysfunction (ED) following nerve-sparing RRP have been published, revealing widely disparate potency rates (30-86%) among various groups in different studies [4][5][6][7][8][9][10][11]. This variation in potency rates may be due to patient selection, surgeon and hospital volume, and the proportion of nerve-sparing procedures [5,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Use of IIEF-5 for Reporting Erectile Dysfunction Following Nerve-Sparing Radical Retropubic Prostatectomy

Albersen¹,

Joniau²,

Poppel³

2009

TOPCANJ

View full text Add to dashboard Cite

Abstract:Introduction: Increased detection of organ-confined prostate cancer has led to an increased demand for nervesparing surgery. Most studies of erectile dysfunction (ED) following nerve-sparing radical prostatectomy (RRP) use single-item assessment, and potency rates differ widely among various groups. We aimed to investigate the use of the IIEF-5, a validated questionnaire, for reporting ED following RRP. Aims: To study the use of the IIEF-5 questionnaire in the evaluation of post-RRP ED, and to find possible variations in ED reporting when comparing IIEF-5 to single-item assessment. Methods: At a minimum of 18 months post-surgery, patients completed a questionnaire on erectile function that included both single-item assessment and the IIEF-5. The study included sexually active patients who reported no pre-operative ED and who did not receive adjuvant or salvage therapy. Main Outcome Measures: For the single-item assessment, potency was defined as "the ability to achieve erections firm enough for intercourse". For the IIEF-5 questionnaire, potency was defined as a score >22 (out of 25) points. Results: Ninety-one patients were included in the study. The procedures consisted of bilateral nerve-sparing (55%) or unilateral or partial bilateral nerve-sparing surgery (45%). We found a striking difference in potency rates when using either IIEF-5 score or single-item assessment for reporting of potency after RRP. The results when using the IIEF-5 questionnaire indicated that 25.5% of all patients were potent. In contrast, single-item assessment indicated a potency rate of 53.8%. Conclusions: Using the IIEF-5 questionnaire to evaluate ED following RRP results in a remarkably lower percentage of men being classified as having no ED. This might be the main reason IIEF-5 is not frequently used in the reporting of ED following radical prostatectomy. Literature search reveals that the IIEF-5 questionnaire is expected to have a higher level of validity, accuracy, and reliability, and may be more stable than single-item assessment. We think that the use of IIEF-5 in the reporting of ED following RRP enhances comparison of different series and of different treatment modalities. However, a prospective comparison between IIEF-5 and single-item assessment is needed to confirm this finding.

show abstract

“…In 1983, Walsh defined nerve locations around the prostate and inspired a number of "nervesparing" surgical approaches, including robotic-assisted laparoscopic prostatectomy (8). Unfortunately, the success of these approaches to mitigate side effects is mixed, (9,10) and surgical approaches are still associated with significant morbidity, for example, incontinence (3%-74%) and impotence (30%-90%; refs. [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Theranostic Agents for Photodynamic Therapy of Prostate Cancer by Targeting Prostate-Specific Membrane Antigen

Wang

Tsui

Ramamurthy

et al. 2016

Molecular Cancer Therapeutics

View full text Add to dashboard Cite

Prostatectomy has been the mainstay treatment for men with localized prostate cancer. Surgery, however, often can result in major side effects, which are caused from damage and removal of nerves and muscles surrounding the prostate. A technology that can help surgeons more precisely identify and remove prostate cancer resulting in a more complete prostatectomy is needed. Prostate-specific membrane antigen (PSMA), a type II membrane antigen highly expressed in prostate cancer, has been an attractive target for imaging and therapy. The objective of this study is to develop low molecular weight PSMA-targeted photodynamic therapy (PDT) agents, which would provide image guidance for prostate tumor resection and allow for subsequent PDT to eliminate unresectable or remaining cancer cells. On the basis of our highly negatively charged, urea-based

show abstract

Potency after unilateral nerve sparing surgery: a report on functional and oncological results of unilateral nerve sparing surgery

Cited by 24 publications

References 22 publications

The older cancer survivor

The older cancer survivor

The Use of IIEF-5 for Reporting Erectile Dysfunction Following Nerve-Sparing Radical Retropubic Prostatectomy

Theranostic Agents for Photodynamic Therapy of Prostate Cancer by Targeting Prostate-Specific Membrane Antigen

Contact Info

Product

Resources

About