“…6 Nucleophiles with relatively acidic C(sp) 3 −H bonds (pK a ≈ 18−25), such as aldehydes, malonic acids, nitroalkanes, and ketones can effectively undergo a deprotonative addition reaction with several electrophiles. 7 Recently, the functionalization of weakly acidic C(sp) 3 −H bonds (pK a > 30), such as esters, nitriles, amides and alkylazaarenes, catalyzed by the Brønsted base has also been developed by Pines,8 Knochel, 9 Guan, 10 Shigeno and Kondo, 11 and Kobayashi. 12,13 More recently, catalytic deprotonation of benzylic C(sp) 3 − H bonds (pK a > 40) of simple toluenes have been reported with Brønsted bases, such as Na or K by Pines,14 n-BuLi/LiK-(OCH 2 CH 2 NMe 2 ) 2 /Mg(OCH 2 CH 2 OEt) 2 by Screttas, 15 TMAF/N(TMS) 3 by Shigeno and Kondo, 16 and t-BuOK and LiTMP or KCH 2 TMS and KN(SiMe 3 ) 2 by Kobayashi.…”