Potassium tert-Butoxide Promoted Intramolecular Amination of 1-Aryl-2- (2-nitrobenzylidene)hydrazines: Efficient Synthesis of 1-Aryl-1H-indazoles

Abstract

1-Aryl-2-(2-nitrobenzylidene)hydrazines readily undergo intramolecular amination to afford 1-aryl-1H-indazole derivatives. The reaction was conducted in the presence of potassium tertbutoxide in N,N-dimethylformamide (DMF) at 100°C and all products were obtained in good yields. Displacement of the nitro group was achieved in the absence of significant electron-withdrawing substituents such as nitro, cyanide, diazo, or carbonyl groups.

Synthesis of novel fused quinazolinone derivatives

“…Furthermore, some isoindoloquinazolinediones were synthe- [17,20,21]. Focusing on the biological potential of fused quinazolinones, in continuation of our work on the synthesis of novel N -heterocycles [22][23][24][25][26][27][28], herein, we report the synthesis of novel fused quinazolinones 8 and 10 starting from isatoic anhydride 1 (Scheme 1).…”