Potassium Perchlorate in Thyrotoxicosis

Morgans, M.E.; Trotter, Wilfred

doi:10.1136/bmj.2.5205.1086-a

Cited by 17 publications

(19 citation statements)

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“…Anions such as perchlorate and iodine are known to affect thyroid hormone production or release (14)(15)(16)(17)(18)(19)(20). In the present study animals given a NID or HID displayed no statistically significant persistent changes in T4, rTSH, or RTg.…”

Section: Discussionmentioning

confidence: 40%

A radioimmunoassay for serum rat thyroglobulin. Physiologic and pharmacological studies.

Herle¹,

Klandorf²,

Uller³

1975

J. Clin. Invest.

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A B S T R A C T A double antibody radioimmunoassay has been developed to measure thyroglobulin in rat (RTg) serum. The lowest detectable quantity measurable was 5.0 ng/ml. Specificity was documented by: (a) fall in serum RTg to undetectable levels after thyroid ablation; (b) the fact that L-thyroxine, D-thyroxine, Ltriiodothyronine, D-triiodothyronine, triiodothyroacetic acid, tetraiodothyroacetic acid, triiodothyropropionic acid, monoiodotyrosine, diiodotyrosine, and human thyroglobulin (HTg) in concentrations up to 40,000 ng per tube did not cross-react in the assay; (c) the demonstration that constant levels of serum RTg were observed while varying amounts of serum (criterion of parallelism) were introduced in the assay. The mean RTg concentration in tail vein blood of adult SpragueDawley rats was 101.5±+13.0 ng/ml (SEM) (n=21); values ranged from 12.0 to 258.0 ng/ml. Chronic administration of a high-iodine diet (HID) did not affect serum thyroglobulin levels. Chronic administration of a low-iodine diet (LID) and propylthiouracil (PTU) led to a statistically significant increase in serum RTg that was accompanied by a significant rise in serum thyrotropin (rTSH). Serum thyroxine (T4) administered to normal rats for 14 days (20 Ag/day subcutaneously) depressed serum RTg concentration from a mean level of 119.4±17.5 ng/ml (n = 19) to a mean of 35.0± 0.27 ng/ml (n = 19) (P < 0.001). While rats were on continuous T4 suppression, bovine thyroid-stimulating hormone (bTSH) given intravenously (2 IU) resulted in a mean maximal increment of RTg of 332.0±81.5 ng/ml (n = 6) at 24 h. IgG-(LATS) long-acting thyroid stimulator injected intravenously resulted in a mean maximal increment of RTg concentration at 96 h of 87.2±14.3 ng/ml (n = 5). Normal IgG had no staPresented at the annual meeting of the American Federation for Clinical Research (Western Section), February 1975, Carmel, Calif.

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Section: Discussionmentioning

confidence: 40%

A radioimmunoassay for serum rat thyroglobulin. Physiologic and pharmacological studies.

Herle¹,

Klandorf²,

Uller³

1975

J. Clin. Invest.

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“…Such an observation had immediate therapeutic application. Treatment of thyrotoxicosis (including GravesÕ disease) with 600-2000 mg potassium perchlorate (430-1400 mg perchlorate) daily for periods of several months or longer was once common practice, particularly in Europe (Barzilai and Sheinfeld, 1966;Morgans and Trotter, 1960). According to Wolff (1998), seven case reports of fatal aplastic anemia between 1961 and 1966 curtailed the therapeutic use at that time.…”

Section: Introductionmentioning

confidence: 96%

Reference dose for perchlorate based on thyroid hormone change in pregnant women as the critical effect

Strawson

Zhao

Dourson

2004

Regulatory Toxicology and Pharmacology

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“…It has been discontinued in most Western countries due to potential bone marrow toxicity. It also causes nausea/vomiting in up to 10% of cases (Crooks and Wayne, 1960;Morgans and Trotter, 1960;Fumarola et al, 2010).…”

Section: Perchloratesmentioning

confidence: 99%