Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone
Wanpen Vongpatanasin,
John M. Giacona,
Danielle Pittman
et al.
Abstract:Background:
Thiazide diuretics (TD) are the first-line treatment of hypertension because of its consistent benefit in lowering BP and cardiovascular risk. TD is also known to cause an excess risk of diabetes, which may limit long-term use. Although potassium (K) depletion was thought to be the main mechanism of TD-induced hyperglycemia, TD also triggers magnesium (Mg) depletion. However, the role of Mg supplementation in modulating metabolic side effects of TD has not been investigated. Therefore, … Show more
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